Postnatal choline supplementation selectively attenuates hippocampal microRNA alterations associated with developmental alcohol exposure

• Published in: Alcohol (Fayetteville, N.Y.) Vol. 60; pp. 159 - 167
• Main Authors: Balaraman, Sridevi, Idrus, Nirelia M., Miranda, Rajesh C., Thomas, Jennifer D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2017; Elsevier Limited
• Subjects: Acetylcholine; Acetylcholine receptors (nicotinic); Adults; Alcohol; Alcohol use; Animal models; Animals; Animals, Newborn; Apoptosis; Behavior; Biochemistry; Blood Alcohol Content; Brain research; Cell culture; Cell proliferation; Cerebellum; Choline; Choline - administration & dosage; Disease control; Disease Models, Animal; DNA methylation; Epigenetics; Ethanol - blood; Female; Fetal alcohol; Fetal Alcohol Spectrum Disorders - drug therapy; Fetal Alcohol Spectrum Disorders - genetics; Fetal Alcohol Spectrum Disorders - metabolism; Fetal alcohol syndrome; Gene expression; Gene Expression Regulation, Developmental - drug effects; Genetic; Heart diseases; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Intervention; Male; Mating; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Myelination; Nervous system; Neural stem cells; Neuronal-glial interactions; Neuroprotective Agents - administration & dosage; Neurosciences; Nutrition; Pregnancy; Prenatal experience; Psychiatry; Quality of life; Rats, Sprague-Dawley; Rodents; Synaptogenesis; Temperature effects; Therapeutic applications; Thomas, Garrison; Time Factors; Weight Gain - drug effects; United States > US; Intervention; Genetic; miRNA; Fetal alcohol; Choline

Prenatal alcohol exposure can result in a range of physical, neuropathological, and behavioral alterations, collectively termed fetal alcohol spectrum disorders (FASD). We have shown that supplementation with the nutrient choline reduces the severity of developmental alcohol-associated deficits in h...