Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial

• Published in: The Lancet (British edition) Vol. 389; no. 10066; pp. 276 - 286
• Main Authors: Natsume, Osamu, Kabashima, Shigenori, Nakazato, Junko, Yamamoto-Hanada, Kiwako, Narita, Masami, Kondo, Mai, Saito, Mayako, Kishino, Ai, Takimoto, Tetsuya, Inoue, Eisuke, Tang, Julian, Kido, Hiroshi, Wong, Gary W K, Matsumoto, Kenji, Saito, Hirohisa, Ohya, Yukihiro
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 21.01.2017; Elsevier Limited
• Subjects: Allergies; Babies; Clinical trials; Desensitization, Immunologic - methods; Diet; Double-Blind Method; Eczema; Eczema - immunology; Eczema - prevention & control; Egg Hypersensitivity - immunology; Egg Hypersensitivity - prevention & control; Eggs; Female; Food; Food allergies; Humans; Immunoglobulin E - metabolism; Infant; Infants; Ingestion; Internal Medicine; Male; Prevention; Risk Factors; Skin diseases; Treatment Outcome

Evidence is accumulating that early consumption is more beneficial than is delayed introduction as a strategy for primary prevention of food allergy. However, allergic reactions caused by early introduction of such solid foods have been a problematic issue. We investigated whether or not early stepw...