Mechanosensitivity and compositional dynamics of cell-matrix adhesions

• Published in: EMBO reports Vol. 14; no. 6; pp. 509 - 519
• Main Authors: Schiller, Herbert B, Fässler, Reinhard
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.06.2013; Nature Publishing Group UK; Blackwell Publishing Ltd; Nature Publishing Group
• Subjects: Adhesion; Adhesives; adhesome; Animals; Cell Adhesion; Cell adhesion & migration; Cell Adhesion Molecules - chemistry; Cell Adhesion Molecules - metabolism; Cellular biology; Cohesion; Cytoskeleton; EMBO05; EMBO31; EMBO37; extracellular matrix; Extracellular Matrix - physiology; Feedback, Physiological; focal adhesion; Focal Adhesions - physiology; Humans; integrins; Integrins - metabolism; Mechanotransduction, Cellular; Myosin Type II - metabolism; Protein Structure, Tertiary; Proteins; Proteomics; quantitative proteomics; Review; focal adhesion; integrins; adhesome; quantitative proteomics; extracellular matrix

Cells perceive information about the biochemical and biophysical properties of their tissue microenvironment through integrin‐mediated cell–matrix adhesions, which connect the cytoskeleton with the extracellular matrix and thereby allow cohesion and long‐range mechanical connections within tissues....