Development of an Oral Operant Nicotine/Ethanol Co-Use Model in Alcohol-Preferring (P) Rats

• Published in: Alcoholism, clinical and experimental research Vol. 36; no. 11; pp. 1963 - 1972
• Main Authors: Hauser, Sheketha R., Katner, Simon N., Deehan Jr, Gerald A., Ding, Zheng-Ming, Toalston, Jamie E., Scott, Briana J., Bell, Richard L., McBride, William J., Rodd, Zachary A.
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Blackwell Publishing Ltd 01.11.2012; Wiley
• Subjects: Administration, Oral; Alcohol Drinking - adverse effects; Alcohol Drinking - psychology; Alcohol-Preferring P Rat; Alcoholism and acute alcohol poisoning; Animals; Behavior, Addictive - chemically induced; Behavior, Addictive - psychology; Biological and medical sciences; Co-Abuse; Co-Use; Conditioning, Operant - drug effects; Conditioning, Operant - physiology; Ethanol; Ethanol - administration & dosage; Ethanol - toxicity; EtOH + Nicotine-Seeking; Female; Medical sciences; Models, Animal; Nicotine; Nicotine - administration & dosage; Nicotine - toxicity; Pavlovian Spontaneous Recovery; Rats; Reinforcement Schedule; Relapse; Self Administration; Tobacco Use Disorder - psychology; Tobacco, tobacco smoking; Toxicology; Consumption; Co-Use; Relapse; Abuse; Ethanol; Rat; Spontaneous; Rodentia; Co-Abuse; Classical conditioning; Recovery; Learning; Alcoholic beverage; EtOH + Nicotine-Seeking; Alkaloid; Vertebrata; Mammalia; Acquisition process; Animal; Pavlovian Spontaneous Recovery; Development; Models; Nicotine; Alcohol-Preferring P Rat

Background Alcohol abuse is frequently associated with nicotine (Nic) use. The current experiments were conducted to establish an oral operant ethanol + Nic (EtOH + Nic) co‐use model and to characterize some aspects of EtOH + Nic co‐use. Methods Rats were allowed to choose between EtOH alone or EtOH...