腹腔镜下射频凝血器对家兔VX2肝癌模型的疗效研究
目的探讨腹腔镜下射频凝血器在肝癌切除术中的疗效。 方法将VX2 细胞株移植瘤组织注射种植于家兔肝左外叶,建立肝癌模型。将成模家兔45只分为实验组(23只)和对照组(20只),对照组实施常规开腹肝癌切除术,实验组实施腹腔镜下射频凝血器辅助肝癌切除术,比较两组家兔术中出血量、手术持续时间及术后并发症;术后60 d评估总体生存率,并行剖腹探查术探查腹腔转移情况。 结果家兔VX2肝癌模型建模成功率达90.00%(45/50),实验组家兔术中出血量、术后胆瘘及感染发生率均明显低于对照组,差异均有统计学意义(P<0.05);两组家兔手术持续时间、术后腹水、腹腔脓肿及出血发生率比较,差异均无统...
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| Published in | 现代医药卫生 Vol. 33; no. 23; pp. 3546 - 3548 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
云阳县中医院普通外科,重庆,404500%重庆市人民医院肝胆外科 400013
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1009-5519 |
| DOI | 10.3969/j.issn.1009-5519.2017.23.004 |
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| Abstract | 目的探讨腹腔镜下射频凝血器在肝癌切除术中的疗效。 方法将VX2 细胞株移植瘤组织注射种植于家兔肝左外叶,建立肝癌模型。将成模家兔45只分为实验组(23只)和对照组(20只),对照组实施常规开腹肝癌切除术,实验组实施腹腔镜下射频凝血器辅助肝癌切除术,比较两组家兔术中出血量、手术持续时间及术后并发症;术后60 d评估总体生存率,并行剖腹探查术探查腹腔转移情况。 结果家兔VX2肝癌模型建模成功率达90.00%(45/50),实验组家兔术中出血量、术后胆瘘及感染发生率均明显低于对照组,差异均有统计学意义(P<0.05);两组家兔手术持续时间、术后腹水、腹腔脓肿及出血发生率比较,差异均无统计学意义(P>0.05);实验组家兔术后60 d总体生存率明显高于对照组,差异有统计学意义(P<0.05),而腹腔转移率与对照组比较,差异无统计学意义(P>0.05)。 结论腹腔镜下射频凝血器辅助肝癌切除术能减少术中出血量,降低术后并发症,提高术后总体生存率,且不增加术后腹腔转移,具有较高的安全性及应用价值。 |
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| AbstractList | 目的探讨腹腔镜下射频凝血器在肝癌切除术中的疗效。 方法将VX2 细胞株移植瘤组织注射种植于家兔肝左外叶,建立肝癌模型。将成模家兔45只分为实验组(23只)和对照组(20只),对照组实施常规开腹肝癌切除术,实验组实施腹腔镜下射频凝血器辅助肝癌切除术,比较两组家兔术中出血量、手术持续时间及术后并发症;术后60 d评估总体生存率,并行剖腹探查术探查腹腔转移情况。 结果家兔VX2肝癌模型建模成功率达90.00%(45/50),实验组家兔术中出血量、术后胆瘘及感染发生率均明显低于对照组,差异均有统计学意义(P<0.05);两组家兔手术持续时间、术后腹水、腹腔脓肿及出血发生率比较,差异均无统计学意义(P>0.05);实验组家兔术后60 d总体生存率明显高于对照组,差异有统计学意义(P<0.05),而腹腔转移率与对照组比较,差异无统计学意义(P>0.05)。 结论腹腔镜下射频凝血器辅助肝癌切除术能减少术中出血量,降低术后并发症,提高术后总体生存率,且不增加术后腹腔转移,具有较高的安全性及应用价值。 目的 探讨腹腔镜下射频凝血器在肝癌切除术中的疗效.方法 将VX2细胞株移植瘤组织注射种植于家兔肝左外叶,建立肝癌模型.将成模家兔45只分为实验组(23只)和对照组(20只),对照组实施常规开腹肝癌切除术,实验组实施腹腔镜下射频凝血器辅助肝癌切除术,比较两组家兔术中出血量、手术持续时间及术后并发症;术后60 d评估总体生存率,并行剖腹探查术探查腹腔转移情况.结果 家兔VX2肝癌模型建模成功率达90.00%(45/50),实验组家兔术中出血量、术后胆瘘及感染发生率均明显低于对照组,差异均有统计学意义(P<0.05);两组家兔手术持续时间、术后腹水、腹腔脓肿及出血发生率比较,差异均无统计学意义(P>0.05);实验组家兔术后60 d总体生存率明显高于对照组,差异有统计学意义(P<0.05),而腹腔转移率与对照组比较,差异无统计学意义(P>0.05).结论 腹腔镜下射频凝血器辅助肝癌切除术能减少术中出血量,降低术后并发症,提高术后总体生存率,且不增加术后腹腔转移,具有较高的安全性及应用价值. |
| Author | 陈云卫;宋晓雪;吴堃;谢炜 |
| AuthorAffiliation | 云阳县中医院普通外科,重庆404500;重庆市人民医院肝胆外科,400013 |
| AuthorAffiliation_xml | – name: 云阳县中医院普通外科,重庆,404500%重庆市人民医院肝胆外科 400013 |
| Author_FL | Wu Kun Song Xiaoxue Chen Yunwei Xie Wei |
| Author_FL_xml | – sequence: 1 fullname: Chen Yunwei – sequence: 2 fullname: Song Xiaoxue – sequence: 3 fullname: Wu Kun – sequence: 4 fullname: Xie Wei |
| Author_xml | – sequence: 1 fullname: 陈云卫;宋晓雪;吴堃;谢炜 |
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| DOI | 10.3969/j.issn.1009-5519.2017.23.004 |
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| DocumentTitleAlternate | Study on curative effect of radiofrequency coagulator under laparoscopy in rabbit VX2 hepatocellular carcinoma model |
| DocumentTitle_FL | Study on curative effect of radiofrequency coagulator under laparoscopy in rabbit VX2 hepatocellular carcinoma model |
| EndPage | 3548 |
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| Issue | 23 |
| Keywords | 肝肿瘤 手术后并发症 兔 腹腔镜 射频消融 导管消融术 疾病模型,动物 |
| Language | Chinese |
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| Notes | Catheter ablation; Laparoscopes; Liver neoplasm; Disease models,animal; Postoperative complications; Radiofrequency ablation; Rabbits Objective〓To investigate the curative effect of radiofrequency coagulator under laparoscopy for hepatocellular carcinoma(HCC)resection.Methods〓The VX2cell line xenograft tissue was grown in the left lateral lobe of rabbit liver by injection for establishing the HCC model.Then the model rabbits were divided into the experimental group(23)and controy group(20).The experimental group implemented radiofrequency coagulator assisted laparoscopic hepatectomy under laparoscopy,while the control group conducted the open hepatectomy.The intraoperative blood loss volume,surgery duration and postoperative complications were compared between the two operative modes;the overall survival rate was assessed on postoperative60d and the exploratory laparotomy was performed for investigating the peritoneal metastasis situation.Results〓The success rate of rabbit VX2HCC model construction reached90.0 |
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| PublicationTitle | 现代医药卫生 |
| PublicationTitleAlternate | Modern Medicine Health |
| PublicationTitle_FL | Journal of Modern Medicine & Health |
| PublicationYear | 2017 |
| Publisher | 云阳县中医院普通外科,重庆,404500%重庆市人民医院肝胆外科 400013 |
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| Snippet | 目的探讨腹腔镜下射频凝血器在肝癌切除术中的疗效。 方法将VX2 细胞株移植瘤组织注射种植于家兔肝左外叶,建立肝癌模型。将成模家兔45只分为实验组(23只)和对照组(20只),对照组实施常规开腹肝癌切除术,实验组实施腹腔镜下射频凝血器辅助肝癌切除术,比较两组家兔术中出血量、手术持续时间及术后并发症;术后60... 目的 探讨腹腔镜下射频凝血器在肝癌切除术中的疗效.方法 将VX2细胞株移植瘤组织注射种植于家兔肝左外叶,建立肝癌模型.将成模家兔45只分为实验组(23只)和对照组(20只),对照组实施常规开腹肝癌切除术,实验组实施腹腔镜下射频凝血器辅助肝癌切除术,比较两组家兔术中出血量、手术持续时间及术后并发症;术后60... |
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| StartPage | 3546 |
| SubjectTerms | 兔 导管消融术 射频消融 手术后并发症 疾病模型,动物 肝肿瘤 腹腔镜 |
| Title | 腹腔镜下射频凝血器对家兔VX2肝癌模型的疗效研究 |
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