血清-腹水白蛋白梯度与肝硬化食管胃底静脉曲张破裂出血关系的Meta分析
目的探讨血清-腹水白蛋白梯度（SAAG）与肝硬化食管胃底静脉曲张破裂出血之间的关系。方法检索Pub Med、Embase、the Cochrane Library、万方、维普及CNKI数据库于2001年1月-2015年6月发表的所有有关SAAG与肝硬化食管胃底静脉曲张出血的中文文献,每篇文献均需设立出血组和未出血组。应用加强观察性流行病学研究报告质量为参考标准评价文献质量。合并各文献出血组和未出血组SAAG均数及标准差。采用Meta-Analyst软件计算每篇文献中出血组和未出血组SAAG标准化均值差（SMD）并进行Meta分析,多组间计数资料比较采用行×列χ2检验。结果共有13篇文献符合纳入...
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| Published in | 临床肝胆病杂志 Vol. 32; no. 2; pp. 269 - 274 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
首都医科大学附属北京天坛医院消化内科,北京,100050
2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 |
| DOI | 10.3969/j.issn.1001-5256.2016.02.014 |
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| Abstract | 目的探讨血清-腹水白蛋白梯度（SAAG）与肝硬化食管胃底静脉曲张破裂出血之间的关系。方法检索Pub Med、Embase、the Cochrane Library、万方、维普及CNKI数据库于2001年1月-2015年6月发表的所有有关SAAG与肝硬化食管胃底静脉曲张出血的中文文献,每篇文献均需设立出血组和未出血组。应用加强观察性流行病学研究报告质量为参考标准评价文献质量。合并各文献出血组和未出血组SAAG均数及标准差。采用Meta-Analyst软件计算每篇文献中出血组和未出血组SAAG标准化均值差（SMD）并进行Meta分析,多组间计数资料比较采用行×列χ2检验。结果共有13篇文献符合纳入标准。出血组SAAG为（22.54±4.69）g/L,未出血组SAAG为（15.91±4.20）g/L。异质性检验提示存在显著的异质性（Q=100.735,I2=89.065,P〈0.001）,出血组SAAG值显著高于未出血组,两组SAAG值差异有统计学意义（SMD=1.970,95%可信区间：1.425～2.515,P〈0.001）。根据SAAG水平分为SAAG〈15 g/L、15 g/L≤SAAG≤19.9 g/L和SAAG≥20 g/L 3组,随着SAAG水平的升高,3组发生静脉曲张破裂出血者的比例也逐渐升高,且差异有统计学意义（χ2=111.702,P〈0.001）。结论 SAAG与肝硬化食管胃底静脉曲张破裂出血存在密切关系。出血组SAAG水平显著高于未出血组。SAAG有望成为预测肝硬化食管胃底静脉曲张破裂出血的一种有价值指标。 |
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| AbstractList | R575.2; 目的 探讨血清-腹水白蛋白梯度(SAAG)与肝硬化食管胃底静脉曲张破裂出血之间的关系.方法 检索PubMed、Em-base、the Cochrane Library、万方、维普及CNKI数据库于2001年1月-2015年6月发表的所有有关SAAG与肝硬化食管胃底静脉曲张出血的中文文献,每篇文献均需设立出血组和未出血组.应用加强观察性流行病学研究报告质量为参考标准评价文献质量.合并各文献出血组和未出血组SAAG均数及标准差.采用Meta-Analyst软件计算每篇文献中出血组和未出血组SAAG标准化均值差(SMD)并进行Meta分析,多组间计数资料比较采用行x列,检验.结果 共有13篇文献符合纳入标准.出血组SAAG为(22.54 ±4.69) g/L,未出血组SAAG为(15.91±4.20)g/L.异质性检验提示存在显著的异质性(Q=100.735,I2=89.065,P＜0.001),出血组SAAG值显著高于未出血组,两组SAAG值差异有统计学意义(SMD=1.970,95％可信区间:1.425 ～2.515,P＜0.001).根据SAAG水平分为SAAG＜ 15 g/L、15 g/L≤SAAG≤19.9 g/L和SAAG≥20 g/L 3组,随着SAAG水平的升高,3组发生静脉曲张破裂出血者的比例也逐渐升高,且差异有统计学意义(x2=111.702,P＜0.001).结论 SAAG与肝硬化食管胃底静脉曲张破裂出血存在密切关系.出血组SAAG水平显著高于未出血组.SAAG有望成为预测肝硬化食管胃底静脉曲张破裂出血的一种有价值指标. 目的探讨血清-腹水白蛋白梯度（SAAG）与肝硬化食管胃底静脉曲张破裂出血之间的关系。方法检索Pub Med、Embase、the Cochrane Library、万方、维普及CNKI数据库于2001年1月-2015年6月发表的所有有关SAAG与肝硬化食管胃底静脉曲张出血的中文文献,每篇文献均需设立出血组和未出血组。应用加强观察性流行病学研究报告质量为参考标准评价文献质量。合并各文献出血组和未出血组SAAG均数及标准差。采用Meta-Analyst软件计算每篇文献中出血组和未出血组SAAG标准化均值差（SMD）并进行Meta分析,多组间计数资料比较采用行×列χ2检验。结果共有13篇文献符合纳入标准。出血组SAAG为（22.54±4.69）g/L,未出血组SAAG为（15.91±4.20）g/L。异质性检验提示存在显著的异质性（Q=100.735,I2=89.065,P〈0.001）,出血组SAAG值显著高于未出血组,两组SAAG值差异有统计学意义（SMD=1.970,95%可信区间：1.425～2.515,P〈0.001）。根据SAAG水平分为SAAG〈15 g/L、15 g/L≤SAAG≤19.9 g/L和SAAG≥20 g/L 3组,随着SAAG水平的升高,3组发生静脉曲张破裂出血者的比例也逐渐升高,且差异有统计学意义（χ2=111.702,P〈0.001）。结论 SAAG与肝硬化食管胃底静脉曲张破裂出血存在密切关系。出血组SAAG水平显著高于未出血组。SAAG有望成为预测肝硬化食管胃底静脉曲张破裂出血的一种有价值指标。 |
| Author | 张辉 徐有青 |
| AuthorAffiliation | 首都医科大学附属北京天坛医院消化内科,北京100050 |
| AuthorAffiliation_xml | – name: 首都医科大学附属北京天坛医院消化内科,北京,100050 |
| Author_FL | ZHANG Hui XU Youqing |
| Author_FL_xml | – sequence: 1 fullname: ZHANG Hui – sequence: 2 fullname: XU Youqing |
| Author_xml | – sequence: 1 fullname: 张辉 徐有青 |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| DOI | 10.3969/j.issn.1001-5256.2016.02.014 |
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| DocumentTitleAlternate | Association between serum ascites albumin gradient and esophagogastric variceal bleeding in patients with liver cir- rhosis： a Meta - analysis |
| DocumentTitle_FL | Association between serum ascites albumin gradient and esophagogastric variceal bleeding in patients with liver cirrhosis: a Meta-analysis |
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| Keywords | 血清腹水白蛋白梯度 portal hypertension 食管和胃静脉曲张 肝硬化 esophageal and gastric varies Meta分析 门静脉高压 liver cirrhosis serum-ascites albumin concentration gradient Meta-analysis |
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| Notes | ZHANG Hui, XU Youqing. （Department of Gastroenterology, Beijing Tian Tan Hospital, Capital Medical University, Belting 100050, China） Objective To investigate the association between serum ascites albumin gradient （SAAG） and esophagogastric variceal bleeding in patients with liver cirrhosis. Methods The databases PubMed, Embase, the Cochrane Library, Wanfang Data, VIP, and CNKI were searched to obtain Chinese articles on SAAG and esophagogastric varieeal bleeding in patients with liver cirrhosis published between January 2001 and June 2015, and each article should include a bleeding group and a non - bleeding group. Strengthening the reporting of observational studies in epidemiology （STROBE） was used as a reference to evaluate the quality of articles. The mean ± standard deviation （SD） of SAAG in bleeding groups and non -bleeding groups were pooled and analyzed. The Meta -Analyst software was used to calculate standardized mean differences （SMD） of SAAG between bleeding groups and non - bleeding groups and pe |
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| PublicationTitle | 临床肝胆病杂志 |
| PublicationTitleAlternate | Chinese Journal of Clinical Hepatology |
| PublicationTitle_FL | Journal of Clinical Hepatology |
| PublicationYear | 2016 |
| Publisher | 首都医科大学附属北京天坛医院消化内科,北京,100050 |
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| Snippet | 目的探讨血清-腹水白蛋白梯度（SAAG）与肝硬化食管胃底静脉曲张破裂出血之间的关系。方法检索Pub Med、Embase、the Cochrane... R575.2; 目的 探讨血清-腹水白蛋白梯度(SAAG)与肝硬化食管胃底静脉曲张破裂出血之间的关系.方法 检索PubMed、Em-base、the Cochrane... |
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| SubjectTerms | Meta分析 肝硬化 血清腹水白蛋白梯度 门静脉高压 食管和胃静脉曲张 |
| Title | 血清-腹水白蛋白梯度与肝硬化食管胃底静脉曲张破裂出血关系的Meta分析 |
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