Immunological and metabolic effects of cis-9, trans-11-conjugated linoleic acid in subjects with birch pollen allergy

• Published in: British journal of nutrition Vol. 100; no. 1; pp. 112 - 119
• Main Authors: Turpeinen, Anu M., Ylönen, Niina, von Willebrand, Eva, Basu, Samar, Aro, Antti
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.07.2008
• Subjects: Adult; allergens; Allergies; Allergy; animal proteins; Betula; Betula - immunology; Biological and medical sciences; biosynthesis; blood; Blood Cell Count; Blood Glucose; Blood Glucose - metabolism; Cells, Cultured; chemical structure; chemotherapy; Compliance; Conjugated linoleic acid; Cytokines; Cytokines - biosynthesis; Dairy products; Dietary Supplements; drug effects; drug therapy; eosinophil-derived neurotoxin; excretion; Fatty acids; Feeding. Feeding behavior; Female; Free radicals; Fundamental and applied biological sciences. Psychology; Gene expression; human health; Human subjects; Humans; hypersensitivity; Immune function; Immune response; Immunization; Immunoglobulin; immunoglobulin A; immunoglobulin E; Immunoglobulins; Immunoglobulins - blood; immunology; immunomodulators; in vitro studies; Inflammation Mediators; Inflammation Mediators - metabolism; interferons; interleukin-5; ISO standards; isoprostanes; Linoleic Acids, Conjugated; Linoleic Acids, Conjugated - immunology; Linoleic Acids, Conjugated - therapeutic use; Lipid oxidation; Lipid Peroxidation; Lipid Peroxidation - drug effects; Lipids; Lipids - blood; Lymphocyte Subsets; Lymphocyte Subsets - drug effects; Lymphocyte Subsets - immunology; Lymphocytes; macrophage colony-stimulating factor; Male; MEDICIN; MEDICINE; metabolism; Metabolites; Middle Aged; Neurotoxins; Nutrition; Nutrition research; Oils & fats; Patient Compliance; Peroxidation; Pollen; Pollen - immunology; prevention & control; prostaglandins; Rhinitis, Allergic, Seasonal; Rhinitis, Allergic, Seasonal - blood; Rhinitis, Allergic, Seasonal - immunology; Rhinitis, Allergic, Seasonal - prevention & control; Rodents; Seasons; Severity of Illness Index; signs and symptoms (animals and humans); Sneezing; Sneezing - immunology; therapeutic use; tumor necrosis factor-alpha; urine; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Young Adult; Conjugated linoleic acid; Allergy; Immunoglobulin; Immune function; Cytokines; Lipid oxidation; Human; Immunopathology; Vertebrata; Immunoglobulins; Mammalia; Conjugated linoleic acid: Immune function: Cytokines: Immunoglobulin: Allergy: Lipid oxidation; Cytokine; Lipids; Oxidation; Pollen

Animal studies suggest that conjugated linoleic acid (CLA) may modulate the immune response, while studies in healthy human subjects have shown little effect and results are controversial. However, the effects of CLA may be more prominent in situations of immune imbalance, such as allergy. We studie...