Reduced Serotonin-1A Receptor Binding in Social Anxiety Disorder
Results from studies in serotonin-1A (5-HT 1A) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for 5-HT 1A receptors in normal state anxiety as well as in certain anxiety disorders. The objective of this study was to investigate 5-HT 1A receptor binding p...
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| Published in | Biological psychiatry (1969) Vol. 61; no. 9; pp. 1081 - 1089 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Inc
01.05.2007
Elsevier Science |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Results from studies in serotonin-1A (5-HT
1A) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for 5-HT
1A receptors in normal state anxiety as well as in certain anxiety disorders. The objective of this study was to investigate 5-HT
1A receptor binding potential (BP) in social anxiety disorder (SAD).
Using PET and [carbonyl-
11C]WAY-100635, we compared a homogeneous group of 12 unmedicated, male SAD patients with 18 healthy control subjects (HC). A multivariate ANOVA with all regional BP values as dependent variables, age and four radiochemical variables as covariates was performed.
We found a significantly lower 5-HT
1A BP in several limbic and paralimbic areas but not in the hippocampus (p = .234) of SAD patients. The difference in 5-HT
1A binding was most significant in the amygdala (−21.4%; p = .003). There was also a more than 20% lower 5-HT
1A BP of SAD patients in the anterior cingulate cortex (p = .004), insula (p = .003), and dorsal raphe nuclei (p = .030).
The lower 5-HT
1A binding in the amygdala and mesiofrontal areas of SAD patients is consistent with 1) preclinical findings of elevated anxiety in 5-HT
1A knockout mice, 2) a previous PET study in healthy volunteers showing an inverse correlation between 5-HT
1A BP and state anxiety, and 3) another human PET study in patients with panic disorder showing reduced 5-HT
1A binding, thus corroborating the potential validity of 5-HT
1A receptors as targets in the treatment of human anxiety disorders. |
|---|---|
| AbstractList | Results from studies in serotonin-1A (5-HT
1A) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for 5-HT
1A receptors in normal state anxiety as well as in certain anxiety disorders. The objective of this study was to investigate 5-HT
1A receptor binding potential (BP) in social anxiety disorder (SAD).
Using PET and [carbonyl-
11C]WAY-100635, we compared a homogeneous group of 12 unmedicated, male SAD patients with 18 healthy control subjects (HC). A multivariate ANOVA with all regional BP values as dependent variables, age and four radiochemical variables as covariates was performed.
We found a significantly lower 5-HT
1A BP in several limbic and paralimbic areas but not in the hippocampus (p = .234) of SAD patients. The difference in 5-HT
1A binding was most significant in the amygdala (−21.4%; p = .003). There was also a more than 20% lower 5-HT
1A BP of SAD patients in the anterior cingulate cortex (p = .004), insula (p = .003), and dorsal raphe nuclei (p = .030).
The lower 5-HT
1A binding in the amygdala and mesiofrontal areas of SAD patients is consistent with 1) preclinical findings of elevated anxiety in 5-HT
1A knockout mice, 2) a previous PET study in healthy volunteers showing an inverse correlation between 5-HT
1A BP and state anxiety, and 3) another human PET study in patients with panic disorder showing reduced 5-HT
1A binding, thus corroborating the potential validity of 5-HT
1A receptors as targets in the treatment of human anxiety disorders. Background Results from studies in serotonin-1A (5-HT1A ) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for 5-HT1A receptors in normal state anxiety as well as in certain anxiety disorders. The objective of this study was to investigate 5-HT1A receptor binding potential (BP) in social anxiety disorder (SAD). Methods Using PET and [carbonyl-11 C]WAY-100635, we compared a homogeneous group of 12 unmedicated, male SAD patients with 18 healthy control subjects (HC). A multivariate ANOVA with all regional BP values as dependent variables, age and four radiochemical variables as covariates was performed. Results We found a significantly lower 5-HT1A BP in several limbic and paralimbic areas but not in the hippocampus (p = .234) of SAD patients. The difference in 5-HT1A binding was most significant in the amygdala (−21.4%; p = .003). There was also a more than 20% lower 5-HT1A BP of SAD patients in the anterior cingulate cortex (p = .004), insula (p = .003), and dorsal raphe nuclei (p = .030). Conclusions The lower 5-HT1A binding in the amygdala and mesiofrontal areas of SAD patients is consistent with 1) preclinical findings of elevated anxiety in 5-HT1A knockout mice, 2) a previous PET study in healthy volunteers showing an inverse correlation between 5-HT1A BP and state anxiety, and 3) another human PET study in patients with panic disorder showing reduced 5-HT1A binding, thus corroborating the potential validity of 5-HT1A receptors as targets in the treatment of human anxiety disorders. Background Results from studies in serotonin-1A (5-HT sub(1A)) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for 5-HT sub(1A) receptors in normal state anxiety as well as in certain anxiety disorders. The objective of this study was to investigate 5-HT sub(1A) receptor binding potential (BP) in social anxiety disorder (SAD). Methods Using PET and [carbonyl- super(11)C]WAY-100635, we compared a homogeneous group of 12 unmedicated, male SAD patients with 18 healthy control subjects (HC). A multivariate ANOVA with all regional BP values as dependent variables, age and four radiochemical variables as covariates was performed. Results We found a significantly lower 5-HT sub(1A) BP in several limbic and paralimbic areas but not in the hippocampus (p = .234) of SAD patients. The difference in 5-HT sub(1A) binding was most significant in the amygdala (-21.4%; p = .003). There was also a more than 20% lower 5-HT sub(1A) BP of SAD patients in the anterior cingulate cortex (p = .004), insula (p = .003), and dorsal raphe nuclei (p = .030). Conclusions The lower 5-HT1A binding in the amygdala and mesiofrontal areas of SAD patients is consistent with 1) preclinical findings of elevated anxiety in 5-HT1A knockout mice, 2) a previous PET study in healthy volunteers showing an inverse correlation between 5-HT1A BP and state anxiety, and 3) another human PET study in patients with panic disorder showing reduced 5-HT1A binding, thus corroborating the potential validity of 5-HT1A receptors as targets in the treatment of human anxiety disorders. Results from studies in serotonin-1A (5-HT1A) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for 5-HT1A receptors in normal state anxiety as well as in certain anxiety disorders. The objective of this study was to investigate 5-HT1A receptor binding potential (BP) in social anxiety disorder (SAD). Using PET and [carbonyl-11C]WAY-100635, we compared a homogeneous group of 12 unmedicated, male SAD patients with 18 healthy control subjects (HC). A multivariate ANOVA with all regional BP values as dependent variables, age and four radiochemical variables as covariates was performed. We found a significantly lower 5-HT1A BP in several limbic and paralimbic areas but not in the hippocampus (p = .234) of SAD patients. The difference in 5-HT1A binding was most significant in the amygdala (-21.4%; p = .003). There was also a more than 20% lower 5-HT(1A) BP of SAD patients in the anterior cingulate cortex (p = .004), insula (p = .003), and dorsal raphe nuclei (p = .030). The lower 5-HT1A binding in the amygdala and mesiofrontal areas of SAD patients is consistent with 1) preclinical findings of elevated anxiety in 5-HT1A knockout mice, 2) a previous PET study in healthy volunteers showing an inverse correlation between 5-HT1A BP and state anxiety, and 3) another human PET study in patients with panic disorder showing reduced 5-HT1A binding, thus corroborating the potential validity of 5-HT1A receptors as targets in the treatment of human anxiety disorders. Results from studies in serotonin-1A (5-HT1A) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for 5-HT1A receptors in normal state anxiety as well as in certain anxiety disorders. The objective of this study was to investigate 5-HT1A receptor binding potential (BP) in social anxiety disorder (SAD).BACKGROUNDResults from studies in serotonin-1A (5-HT1A) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for 5-HT1A receptors in normal state anxiety as well as in certain anxiety disorders. The objective of this study was to investigate 5-HT1A receptor binding potential (BP) in social anxiety disorder (SAD).Using PET and [carbonyl-11C]WAY-100635, we compared a homogeneous group of 12 unmedicated, male SAD patients with 18 healthy control subjects (HC). A multivariate ANOVA with all regional BP values as dependent variables, age and four radiochemical variables as covariates was performed.METHODSUsing PET and [carbonyl-11C]WAY-100635, we compared a homogeneous group of 12 unmedicated, male SAD patients with 18 healthy control subjects (HC). A multivariate ANOVA with all regional BP values as dependent variables, age and four radiochemical variables as covariates was performed.We found a significantly lower 5-HT1A BP in several limbic and paralimbic areas but not in the hippocampus (p = .234) of SAD patients. The difference in 5-HT1A binding was most significant in the amygdala (-21.4%; p = .003). There was also a more than 20% lower 5-HT(1A) BP of SAD patients in the anterior cingulate cortex (p = .004), insula (p = .003), and dorsal raphe nuclei (p = .030).RESULTSWe found a significantly lower 5-HT1A BP in several limbic and paralimbic areas but not in the hippocampus (p = .234) of SAD patients. The difference in 5-HT1A binding was most significant in the amygdala (-21.4%; p = .003). There was also a more than 20% lower 5-HT(1A) BP of SAD patients in the anterior cingulate cortex (p = .004), insula (p = .003), and dorsal raphe nuclei (p = .030).The lower 5-HT1A binding in the amygdala and mesiofrontal areas of SAD patients is consistent with 1) preclinical findings of elevated anxiety in 5-HT1A knockout mice, 2) a previous PET study in healthy volunteers showing an inverse correlation between 5-HT1A BP and state anxiety, and 3) another human PET study in patients with panic disorder showing reduced 5-HT1A binding, thus corroborating the potential validity of 5-HT1A receptors as targets in the treatment of human anxiety disorders.CONCLUSIONSThe lower 5-HT1A binding in the amygdala and mesiofrontal areas of SAD patients is consistent with 1) preclinical findings of elevated anxiety in 5-HT1A knockout mice, 2) a previous PET study in healthy volunteers showing an inverse correlation between 5-HT1A BP and state anxiety, and 3) another human PET study in patients with panic disorder showing reduced 5-HT1A binding, thus corroborating the potential validity of 5-HT1A receptors as targets in the treatment of human anxiety disorders. |
| Author | Mien, Leonhard-Key Kletter, Kurt Tauscher, Johannes Klein, Nikolas Lanzenberger, Rupert R. Wadsak, Wolfgang Sacher, Julia Mossaheb, Nilufar Spindelegger, Christoph Holik, Alexander Kasper, Siegfried Attarbaschi, Trawat Mitterhauser, Markus Geiss-Granadia, Thomas |
| Author_xml | – sequence: 1 givenname: Rupert R. surname: Lanzenberger fullname: Lanzenberger, Rupert R. email: rupert.lanzenberger@meduniwien.ac.at organization: Department of General Psychiatry, Medical University of Vienna, Vienna, Austria – sequence: 2 givenname: Markus surname: Mitterhauser fullname: Mitterhauser, Markus organization: Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria – sequence: 3 givenname: Christoph surname: Spindelegger fullname: Spindelegger, Christoph organization: Department of General Psychiatry, Medical University of Vienna, Vienna, Austria – sequence: 4 givenname: Wolfgang surname: Wadsak fullname: Wadsak, Wolfgang organization: Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria – sequence: 5 givenname: Nikolas surname: Klein fullname: Klein, Nikolas organization: Department of General Psychiatry, Medical University of Vienna, Vienna, Austria – sequence: 6 givenname: Leonhard-Key surname: Mien fullname: Mien, Leonhard-Key organization: Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria – sequence: 7 givenname: Alexander surname: Holik fullname: Holik, Alexander organization: Department of General Psychiatry, Medical University of Vienna, Vienna, Austria – sequence: 8 givenname: Trawat surname: Attarbaschi fullname: Attarbaschi, Trawat organization: Department of General Psychiatry, Medical University of Vienna, Vienna, Austria – sequence: 9 givenname: Nilufar surname: Mossaheb fullname: Mossaheb, Nilufar organization: Department of General Psychiatry, Medical University of Vienna, Vienna, Austria – sequence: 10 givenname: Julia surname: Sacher fullname: Sacher, Julia organization: Department of General Psychiatry, Medical University of Vienna, Vienna, Austria – sequence: 11 givenname: Thomas surname: Geiss-Granadia fullname: Geiss-Granadia, Thomas organization: Department of General Psychiatry, Medical University of Vienna, Vienna, Austria – sequence: 12 givenname: Kurt surname: Kletter fullname: Kletter, Kurt organization: Department of Nuclear Medicine, Medical University of Vienna, Vienna, Austria – sequence: 13 givenname: Siegfried surname: Kasper fullname: Kasper, Siegfried organization: Department of General Psychiatry, Medical University of Vienna, Vienna, Austria – sequence: 14 givenname: Johannes surname: Tauscher fullname: Tauscher, Johannes organization: Department of General Psychiatry, Medical University of Vienna, Vienna, Austria |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18701056$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/16979141$$D View this record in MEDLINE/PubMed |
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| Snippet | Results from studies in serotonin-1A (5-HT
1A) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for 5-HT
1A... Background Results from studies in serotonin-1A (5-HT1A ) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for... Results from studies in serotonin-1A (5-HT1A) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for 5-HT1A receptors... Background Results from studies in serotonin-1A (5-HT sub(1A)) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for... |
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| SubjectTerms | 5-HT 1A Adult Adult and adolescent clinical studies Affective disorders anxiety Anxiety disorders. Neuroses Biological and medical sciences Brain - diagnostic imaging Brain Chemistry - physiology Humans Magnetic Resonance Imaging Male Medical sciences PET Phobia Phobic Disorders - diagnostic imaging Phobic Disorders - metabolism Phobic Disorders - psychology Piperazines Positron-Emission Tomography Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Pyridines Receptor, Serotonin, 5-HT1A - metabolism serotonin Serotonin Antagonists social phobia STAI |
| Title | Reduced Serotonin-1A Receptor Binding in Social Anxiety Disorder |
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