Human Primary Cell-Based Organotypic Microtissues for Modeling Small Intestinal Drug Absorption - Ayehunie, Seyoum; Landry, Tim; Stevens, Zachary; Armento, Alex; Hayden, Patrick; Klausner, Mitchell (Pharmaceutical research, 2018)
Keywords: Administration, Oral; Adult; Bioavailability; Biochemistry; Biological Availability; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Caco-2 Cells; Cells; Drug Evaluation, Preclinical - methods; Drug interaction; Drug Interactions; Enterocytes; Enzymes; Epithelial Cells; Female; Fibroblasts; Gastrointestinal agents; Humans; Intestinal Absorption; Intestinal Mucosa - cytology; Intestinal Mucosa - metabolism; Intestine, Small - cytology; Intestine, Small - metabolism; Medical Law; Oral administration; Permeability; Pharmacology/Toxicology; Pharmacy; Physiological aspects; Primary Cell Culture; Research Paper; Small intestine; Tissue Culture Techniques - methods; Young Adult; drug permeation; drug transporters; caco-2; organotypic small intestinal microtissues; drug-drug interaction; drug metabolizing enzymes