Signaling logic of activity-triggered dendritic protein synthesis: an mTOR gate but not a feedback switch

• Published in: PLoS computational biology Vol. 5; no. 2; p. e1000287
• Main Authors: Jain, Pragati, Bhalla, Upinder S
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2009; Public Library of Science (PLoS)
• Subjects: Animals; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - metabolism; Calcium - metabolism; Cellular signal transduction; Chemical reactions; Computational biology; Computational Biology/Computational Neuroscience; Computational Biology/Signaling Networks; Computational Biology/Systems Biology; Dendrites; Dendrites - metabolism; Feedback; Genetic aspects; Kinases; Machinery; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases - metabolism; Nerve Tissue Proteins - biosynthesis; Neuroscience/Neural Homeostasis; Neuroscience/Neuronal Signaling Mechanisms; Physiological aspects; Protein biosynthesis; Protein Kinases - metabolism; Protein synthesis; Proteins; Sensitivity analysis; Signal Transduction; TOR Serine-Threonine Kinases; India; Mitogen-Activated Protein Kinases; Animals; Calcium; Protein Kinases; Signal Transduction; Brain-Derived Neurotrophic Factor; Dendrites; Mice; Nerve Tissue Proteins; TOR Serine-Threonine Kinases; Mice, Knockout

Changes in synaptic efficacy are believed to form the cellular basis for memory. Protein synthesis in dendrites is needed to consolidate long-term synaptic changes. Many signals converge to regulate dendritic protein synthesis, including synaptic and cellular activity, and growth factors. The coordi...