Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study

• Published in: Molecular psychiatry Vol. 25; no. 11; pp. 2818 - 2831
• Main Authors: Villalón-Reina, Julio E., Martínez, Kenia, Qu, Xiaoping, Ching, Christopher R. K., Nir, Talia M., Kothapalli, Deydeep, Corbin, Conor, Sun, Daqiang, Lin, Amy, Forsyth, Jennifer K., Kushan, Leila, Vajdi, Ariana, Jalbrzikowski, Maria, Hansen, Laura, Jonas, Rachel K., van Amelsvoort, Therese, Bakker, Geor, Kates, Wendy R., Antshel, Kevin M., Fremont, Wanda, Campbell, Linda E., McCabe, Kathryn L., Daly, Eileen, Gudbrandsen, Maria, Murphy, Clodagh M., Murphy, Declan, Craig, Michael, Emanuel, Beverly, McDonald-McGinn, Donna M., Vorstman, Jacob A.S., Fiksinski, Ania M., Koops, Sanne, Ruparel, Kosha, Roalf, David, Gur, Raquel E., Eric Schmitt, J., Simon, Tony J., Goodrich-Hunsaker, Naomi J., Durdle, Courtney A., Doherty, Joanne L., Cunningham, Adam C., van den Bree, Marianne, Linden, David E. J., Owen, Michael, Moss, Hayley, Kelly, Sinead, Donohoe, Gary, Murphy, Kieran C., Arango, Celso, Jahanshad, Neda, Thompson, Paul M., Bearden, Carrie E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2020; Nature Publishing Group
• Subjects: 59/57; 631/208; 631/378; 692/53/2421; 692/699/476/1799; Adolescent; Adult; Age; Animal models; Anisotropy; Behavioral Sciences; Biological Psychology; Child; Chromosome 22; Chromosome deletion; Complications and side effects; Corpus callosum; Development and progression; Diffusion Magnetic Resonance Imaging; DiGeorge syndrome; DiGeorge Syndrome - diagnostic imaging; DiGeorge Syndrome - genetics; DiGeorge Syndrome - pathology; Female; Gene deletion; Genetic aspects; Humans; Magnetic resonance imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Neurodevelopmental disorders; Neurogenesis; Neuroimaging; Neurosciences; Pharmacotherapy; Psychiatry; Psychoses; Psychosis; Risk factors; Schizophrenia; Substantia alba; Thalamus; White Matter - diagnostic imaging; White Matter - pathology; Working groups; Young Adult; Spain

22q11.2 deletion syndrome (22q11DS)—a neurodevelopmental condition caused by a hemizygous deletion on chromosome 22—is associated with an elevated risk of psychosis and other developmental brain disorders. Prior single-site diffusion magnetic resonance imaging (dMRI) studies have reported altered wh...