Comparing phenotypic variation between inbred and outbred mice

• Published in: Nature methods Vol. 15; no. 12; pp. 994 - 996
• Main Authors: Tuttle, Alexander H., Philip, Vivek M., Chesler, Elissa J., Mogil, Jeffrey S.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2018; Nature Publishing Group
• Subjects: 631/1647/334/1874/345; 631/1647/767/1424; 631/208/1515; Analysis; Animal experimentation; Animals; Behavior; Bioinformatics; Biological Microscopy; Biological Techniques; Biological Variation, Population; Biomedical and Life Sciences; Biomedical Engineering/Biotechnology; Biomedical research; Coefficient of variation; Comment; Datasets; Displays (Marketing); Experiments; Genetic Variation; House mouse; Hypotheses; Inbreeding; Life Sciences; Males; Medical research; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Neurosciences; Phenotypes; Phenotypic variations; Population; Proteomics; Software; Universities and colleges

Inbred mice are preferred over outbred mice because it is assumed that they display less trait variability. We compared coefficients of variation and did not find evidence of greater trait stability in inbred mice. We conclude that contrary to conventional wisdom, outbred mice might be better subjec...