Comparing phenotypic variation between inbred and outbred mice

Inbred mice are preferred over outbred mice because it is assumed that they display less trait variability. We compared coefficients of variation and did not find evidence of greater trait stability in inbred mice. We conclude that contrary to conventional wisdom, outbred mice might be better subjec...

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Bibliographic Details
Published inNature methods Vol. 15; no. 12; pp. 994 - 996
Main Authors Tuttle, Alexander H., Philip, Vivek M., Chesler, Elissa J., Mogil, Jeffrey S.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.12.2018
Nature Publishing Group
Subjects
631/1647/334/1874/345
631/1647/767/1424
631/208/1515
Analysis
Animal experimentation
Animals
Behavior
Bioinformatics
Biological Microscopy
Biological Techniques
Biological Variation, Population
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedical research
Coefficient of variation
Comment
Datasets
Displays (Marketing)
Experiments
Genetic Variation
House mouse
Hypotheses
Inbreeding
Life Sciences
Males
Medical research
Mice
Mice, Inbred Strains
Mice, Mutant Strains
Neurosciences
Phenotypes
Phenotypic variations
Population
Proteomics
Software
Universities and colleges
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Summary:Inbred mice are preferred over outbred mice because it is assumed that they display less trait variability. We compared coefficients of variation and did not find evidence of greater trait stability in inbred mice. We conclude that contrary to conventional wisdom, outbred mice might be better subjects for most biomedical research.
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ISSN:1548-7091
1548-7105
1548-7105
DOI:10.1038/s41592-018-0224-7