Comparing phenotypic variation between inbred and outbred mice
Inbred mice are preferred over outbred mice because it is assumed that they display less trait variability. We compared coefficients of variation and did not find evidence of greater trait stability in inbred mice. We conclude that contrary to conventional wisdom, outbred mice might be better subjec...
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| Published in | Nature methods Vol. 15; no. 12; pp. 994 - 996 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.12.2018
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Inbred mice are preferred over outbred mice because it is assumed that they display less trait variability. We compared coefficients of variation and did not find evidence of greater trait stability in inbred mice. We conclude that contrary to conventional wisdom, outbred mice might be better subjects for most biomedical research. |
|---|---|
| AbstractList | Inbred mice are preferred over outbred mice with the assumption that they
display less trait variability. We compared coefficients of variation and failed
to find evidence of greater trait stability in inbred mice. We conclude that
contrary to conventional wisdom, outbred mice may be better subjects for most
biomedical research. Inbred mice are preferred over outbred mice because it is assumed that they display less trait variability. We compared coefficients of variation and did not find evidence of greater trait stability in inbred mice. We conclude that contrary to conventional wisdom, outbred mice might be better subjects for most biomedical research. |
| Audience | Academic |
| Author | Philip, Vivek M. Mogil, Jeffrey S. Chesler, Elissa J. Tuttle, Alexander H. |
| AuthorAffiliation | 1 UNC Neuroscience Centre, University of North Carolina at Chapel Hill, NC U.S.A 3 Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC CANADA 2 The Jackson Laboratory, Bar Harbor, ME USA |
| AuthorAffiliation_xml | – name: 1 UNC Neuroscience Centre, University of North Carolina at Chapel Hill, NC U.S.A – name: 2 The Jackson Laboratory, Bar Harbor, ME USA – name: 3 Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC CANADA |
| Author_xml | – sequence: 1 givenname: Alexander H. surname: Tuttle fullname: Tuttle, Alexander H. organization: UNC Neuroscience Centre, University of North Carolina at Chapel Hill – sequence: 2 givenname: Vivek M. surname: Philip fullname: Philip, Vivek M. organization: The Jackson Laboratory – sequence: 3 givenname: Elissa J. orcidid: 0000-0002-5642-5062 surname: Chesler fullname: Chesler, Elissa J. organization: The Jackson Laboratory – sequence: 4 givenname: Jeffrey S. orcidid: 0000-0003-1359-5720 surname: Mogil fullname: Mogil, Jeffrey S. email: jeffrey.mogil@mcgill.ca organization: Alan Edwards Centre for Research on Pain, McGill University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30504873$$D View this record in MEDLINE/PubMed |
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| Snippet | Inbred mice are preferred over outbred mice because it is assumed that they display less trait variability. We compared coefficients of variation and did not... Inbred mice are preferred over outbred mice with the assumption that they display less trait variability. We compared coefficients of variation and failed to... |
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| SubjectTerms | 631/1647/334/1874/345 631/1647/767/1424 631/208/1515 Analysis Animal experimentation Animals Behavior Bioinformatics Biological Microscopy Biological Techniques Biological Variation, Population Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedical research Coefficient of variation Comment Datasets Displays (Marketing) Experiments Genetic Variation House mouse Hypotheses Inbreeding Life Sciences Males Medical research Mice Mice, Inbred Strains Mice, Mutant Strains Neurosciences Phenotypes Phenotypic variations Population Proteomics Software Universities and colleges |
| Title | Comparing phenotypic variation between inbred and outbred mice |
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