Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1 - Rashid, Fahad; Harris, Paul D; Zaher, Manal S; Sobhy, Mohamed A; Joudeh, Luay I; Yan, Chunli; Piwonski, Hubert; Tsutakawa, Susan E; Ivanov, Ivaylo; Tainer, John A; Habuchi, Satoshi; Hamdan, Samir M (eLife, 2017)
Keywords: Analysis; BASIC BIOLOGICAL SCIENCES; Biochemistry; Biophysics and Structural Biology; Deoxyribonucleic acid; DNA; DNA - metabolism; DNA binding proteins; DNA biosynthesis; DNA repair; Endonuclease; expressed proteins in E. coli; FEN1 protein; Flap Endonucleases - metabolism; Fluorescence resonance energy transfer; Genomes; Genomic instability; Genomics; Geometry; Histograms; Human purified proteins; Humans; Labeling; Life Sciences & Biomedicine - Other Topics; Models, Biological; Models, Molecular; Nuclease; Nucleases; Nucleic Acid Conformation; Protein Binding; Protein Conformation; Protein structure; recombinant protein; Recombination; Simulation; Single Molecule Imaging; Standard deviation; Substrate Specificity; Human purified proteins; recombinant protein; biochemistry; structural biology; none; biophysics; expressed proteins in E. coli