Silver nanoparticles induce tight junction disruption and astrocyte neurotoxicity in a rat blood-brain barrier primary triple coculture model - Dan, Mo; Xu, Liming; Shao, Anliang; Cheng, Xiang; Zhang, Cuiping; Yokel, Robert; Takemura, Taro; Hanagata, Nobutaka; Niwa, Masami; Watanabe, Daisuke (International Journal of Nanomedicine, 2015)
Keywords: Animals; Astrocytes; Astrocytes - drug effects; Astrocytes - metabolism; Astrocytes - pathology; Biological Transport; Blood-Brain Barrier; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - metabolism; Brain; Brain - drug effects; Brain - metabolism; Brain - pathology; Cell Membrane Permeability; Cells, Cultured; Coculture Techniques; Drug delivery systems; Drugs; Endothelium, Vascular; Endothelium, Vascular - cytology; Endothelium, Vascular - drug effects; Endothelium, Vascular - metabolism; Gene Expression Profiling; Innovations; International Journal of Nanomedicine; Medicine (General); Metal Nanoparticles; Metal Nanoparticles - administration & dosage; Metal Nanoparticles - chemistry; Microscopy, Electron, Transmission; Models, Biological; Nanoparticles; Original Research; Physiological aspects; R5-920; Rats; Real-Time Polymerase Chain Reaction; Signal Transduction; Signal Transduction - drug effects; Silver; Silver - chemistry; Silver compounds; Tight Junctions; Tight Junctions - drug effects; Tight Junctions - metabolism; Vehicles; global gene expression analysis; Ag nanoparticles; antioxidant defense; astrocytes; BBB model