Effect of 3 months vitamin E supplementation on indices of the cellular and humoral immune response in elderly subjects

• Published in: British journal of nutrition Vol. 78; no. 5; pp. 761 - 774
• Main Authors: De Waart, Frouwkje G., Portengen, Lützen, Doekes, Gert, Verwaal, Corné J., Kok, Frans J.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.11.1997
• Subjects: administration & dosage; Administration, Oral; Aged; Aged, 80 and over; Antibodies, Anti-Idiotypic; Antibodies, Anti-Idiotypic - drug effects; Antibody Formation; Antibody Formation - drug effects; antioxidants; Biological and medical sciences; blood; blood plasma; Cell Division; Cell Division - drug effects; cell-mediated immunity; Cellular immune response; Chair Nutrition and Disease; Chair Nutrition and Health over the Lifecourse; Concanavalin A; Concanavalin A - pharmacology; cytology; Double-Blind Method; Drug Administration Schedule; drug effects; Elderly; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Global Nutrition; HNE Nutrition and Disease; HNE Nutrition and Health over the Lifecourse; HNE Voeding en Gezondheid in de Levenscyclus; HNE Voeding en Ziekte; Human and Clinical Nutrition; Humans; Humoral immune response; humoral immunity; Immunity, Cellular; Immunity, Cellular - drug effects; immunoglobulin A; immunoglobulin G; indicator species; Leukocytes, Mononuclear; Leukocytes, Mononuclear - cytology; Leukocytes, Mononuclear - drug effects; Male; Nutrition and Disease; pharmacology; Phytohemagglutinins; Phytohemagglutinins - pharmacology; Treatment Failure; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vitamin E; Vitamin E - administration & dosage; Vitamin E - blood; vitamin supplements; VLAG; Voeding en Ziekte; Wereldvoeding; Humoral immune response; Vitamin E; Elderly; Cellular immune response; Human; IgA; Immune response; Vitamin; IgG; α-Tocopherol; Supplemented diet; Phytohemagglutinin; Antioxidant; Concanavalin A; Feeding; Blood plasma; Mononuclear cell; Mitogen; Humoral immunity

It has been suggested that decreased immune responsiveness in the elderly may be counteracted by the antioxidant vitamin E. In a 3-month double-blind placebo-controlled intervention trial among elderly subjects aged 65 years and over we studied the effects of a daily dose of 100 mg dl-α-tocopheryl a...