Resilience of Precuneus Neurotrophic Signaling Pathways Despite Amyloid Pathology in Prodromal Alzheimer’s Disease

• Published in: Biological psychiatry (1969) Vol. 77; no. 8; pp. 693 - 703
• Main Authors: Perez, Sylvia E., He, Bin, Nadeem, Muhammad, Wuu, Joanne, Scheff, Stephen W., Abrahamson, Eric E., Ikonomovic, Milos D., Mufson, Elliott J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2015
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer’s disease; Amyloid; Amyloid beta-Peptides - metabolism; Aniline Compounds - pharmacokinetics; Choline O-Acetyltransferase; Cognitive Dysfunction - pathology; Female; Humans; In Vitro Techniques; Male; Mental Status Schedule; Mild cognitive impairment; Nerve Growth Factor - metabolism; Neuropathology; Neuropil Threads - pathology; Neurotrophic factors; Parietal Lobe - metabolism; Prodromal Symptoms; Proto-Oncogene Proteins c-bcl-2 - metabolism; Psychiatric/Mental Health; Signal Transduction - drug effects; Signal Transduction - physiology; Statistics, Nonparametric; Tau; Thiazoles - pharmacokinetics; Tritium - pharmacokinetics; Tau; Amyloid; Alzheimer’s disease; Neurotrophic factors; Mild cognitive impairment; Neuropathology

Reduction of precuneus choline acetyltransferase activity co-occurs with greater beta-amyloid (Aβ) in Alzheimer’s disease (AD). Whether this cholinergic deficit is associated with alteration in nerve growth factor (NGF) signaling and its relation to Aβ plaque and neurofibrillary tangle (NFT) patholo...