Composition, variability, and temporal stability of the intestinal microbiota of the elderly

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. Supplement 1; pp. 4586 - 4591
• Main Authors: Claesson, Marcus J, Cusack, Siobhán, O'Sullivan, Orla, Greene-Diniz, Rachel, de Weerd, Heleen, Flannery, Edel, Marchesi, Julian R, Falush, Daniel, Dinan, Timothy, Fitzgerald, Gerald, Stanton, Catherine, van Sinderen, Douwe, O'Connor, Michael, Harnedy, Norma, O'Connor, Kieran, Henry, Colm, O'Mahony, Denis, Fitzgerald, Anthony P, Shanahan, Fergus, Twomey, Cillian, Hill, Colin, Ross, R. Paul, O'Toole, Paul W
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 15.03.2011; National Acad Sciences
• Series: Colloquium Paper
• Subjects: Actinobacteria; Age Factors; Aged; Aged, 80 and over; Antibiotics; Bacteria - classification; Bacteria - genetics; Bacteroides; Bacteroidetes; Base Sequence; Biological Sciences; Clostridium; Cluster Analysis; Colloquium Papers; Computational Biology; data collection; Datasets; elderly; Feces - microbiology; Firmicutes; genes; Humans; infants; inflammatory bowel disease; Inflammatory bowel diseases; intestinal microorganisms; Intestines - microbiology; Ireland; irritable bowel syndrome; Metagenome - genetics; Microbiota; Molecular Sequence Data; obesity; Older adults; Phylogenetics; Phylogeny; Principal Component Analysis; Proportions; Proteobacteria; ribosomal RNA; RNA, Ribosomal, 16S - genetics; sequence analysis; Sequence Analysis, DNA; Species Specificity; Statistics, Nonparametric; Ireland

Alterations in the human intestinal microbiota are linked to conditions including inflammatory bowel disease, irritable bowel syndrome, and obesity. The microbiota also undergoes substantial changes at the extremes of life, in infants and older people, the ramifications of which are still being expl...