Composition, variability, and temporal stability of the intestinal microbiota of the elderly
Alterations in the human intestinal microbiota are linked to conditions including inflammatory bowel disease, irritable bowel syndrome, and obesity. The microbiota also undergoes substantial changes at the extremes of life, in infants and older people, the ramifications of which are still being expl...
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| Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. Supplement 1; pp. 4586 - 4591 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
National Academy of Sciences
15.03.2011
National Acad Sciences |
| Series | Colloquium Paper |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Alterations in the human intestinal microbiota are linked to conditions including inflammatory bowel disease, irritable bowel syndrome, and obesity. The microbiota also undergoes substantial changes at the extremes of life, in infants and older people, the ramifications of which are still being explored. We applied pyrosequencing of over 40,000 16S rRNA gene V4 region amplicons per subject to characterize the fecal microbiota in 161 subjects aged 65 y and older and 9 younger control subjects. The microbiota of each individual subject constituted a unique profile that was separable from all others. In 68% of the individuals, the microbiota was dominated by phylum Bacteroides, with an average proportion of 57% across all 161 baseline samples. Phylum Firmicutes had an average proportion of 40%. The proportions of some phyla and genera associated with disease or health also varied dramatically, including Proteobacteria, Actinobacteria, and FAECALIBACTERIA: The core microbiota of elderly subjects was distinct from that previously established for younger adults, with a greater proportion of Bacteroides spp. and distinct abundance patterns of Clostridium groups. Analyses of 26 fecal microbiota datasets from 3-month follow-up samples indicated that in 85% of the subjects, the microbiota composition was more like the corresponding time-0 sample than any other dataset. We conclude that the fecal microbiota of the elderly shows temporal stability over limited time in the majority of subjects but is characterized by unusual phylum proportions and extreme variability. |
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| AbstractList | Alterations in the human intestinal microbiota are linked to conditions including inflammatory bowel disease, irritable bowel syndrome, and obesity. The microbiota also undergoes substantial changes at the extremes of life, in infants and older people, the ramifications of which are still being explored. We applied pyrosequencing of over 40,000 16S rRNA gene V4 region amplicons per subject to characterize the fecal microbiota in 161 subjects aged 65 y and older and 9 younger control subjects. The microbiota of each individual subject constituted a unique profile that was separable from all others. In 68% of the individuals, the microbiota was dominated by phylum Bacteroides, with an average proportion of 57% across all 161 baseline samples. Phylum Firmicutes had an average proportion of 40%. The proportions of some phyla and genera associated with disease or health also varied dramatically, including Proteobacteria, Actinobacteria, and Faecalibacteria. The core microbiota of elderly subjects was distinct from that previously established for younger adults, with a greater proportion of Bacteroides spp. and distinct abundance patterns of Clostridium groups. Analyses of 26 fecal microbiota datasets from 3-month follow-up samples indicated that in 85% of the subjects, the microbiota composition was more like the corresponding time-0 sample than any other dataset. We conclude that the fecal microbiota of the elderly shows temporal stability over limited time in the majority of subjects but is characterized by unusual phylum proportions and extreme variability. Alterations in the human intestinal microbiota are linked to conditions including inflammatory bowel disease, irritable bowel syndrome, and obesity. The microbiota also undergoes substantial changes at the extremes of life, in infants and older people, the ramifications of which are still being explored. We applied pyrosequencing of over 40,000 16S rRNA gene V4 region amplicons per subject to characterize the fecal microbiota in 161 subjects aged 65 y and older and 9 younger control subjects. The microbiota of each individual subject constituted a unique profile that was separable from all others. In 68% of the individuals, the microbiota was dominated by phylum Bacteroides , with an average proportion of 57% across all 161 baseline samples. Phylum Firmicutes had an average proportion of 40%. The proportions of some phyla and genera associated with disease or health also varied dramatically, including Proteobacteria , Actinobacteria , and Faecalibacteria . The core microbiota of elderly subjects was distinct from that previously established for younger adults, with a greater proportion of Bacteroides spp. and distinct abundance patterns of Clostridium groups. Analyses of 26 fecal microbiota datasets from 3-month follow-up samples indicated that in 85% of the subjects, the microbiota composition was more like the corresponding time-0 sample than any other dataset. We conclude that the fecal microbiota of the elderly shows temporal stability over limited time in the majority of subjects but is characterized by unusual phylum proportions and extreme variability. Alterations in the human intestinal microbiota are linked to conditions including inflammatory bowel disease, irritable bowel syndrome, and obesity. The microbiota also undergoes substantial changes at the extremes of life, in infants and older people, the ramifications of which are still being explored. We applied pyrosequencing of over 40,000 16S rRNA gene V4 region amplicons per subject to characterize the fecal microbiota in 161 subjects aged 65 y and older and 9 younger control subjects. The microbiota of each individual subject constituted a unique profile that was separable from all others. In 68% of the individuals, the microbiota was dominated by phylum Bacteroides, with an average proportion of 57% across all 161 baseline samples. Phylum Firmicutes had an average proportion of 40%. The proportions of some phyla and genera associated with disease or health also varied dramatically, including Proteobacteria, Actinobacteria, and Faecalibacteria. The core microbiota of elderly subjects was distinct from that previously established for younger adults, with a greater proportion of Bacteroides spp. and distinct abundance patterns of Clostridium groups. Analyses of 26 fecal microbiota datasets from 3-month follow-up samples indicated that in 85% of the subjects, the microbiota composition was more like the corresponding time-0 sample than any other dataset. We conclude that the fecal microbiota of the elderly shows temporal stability over limited time in the majority of subjects but is characterized by unusual phylum proportions and extreme variability.Alterations in the human intestinal microbiota are linked to conditions including inflammatory bowel disease, irritable bowel syndrome, and obesity. The microbiota also undergoes substantial changes at the extremes of life, in infants and older people, the ramifications of which are still being explored. We applied pyrosequencing of over 40,000 16S rRNA gene V4 region amplicons per subject to characterize the fecal microbiota in 161 subjects aged 65 y and older and 9 younger control subjects. The microbiota of each individual subject constituted a unique profile that was separable from all others. In 68% of the individuals, the microbiota was dominated by phylum Bacteroides, with an average proportion of 57% across all 161 baseline samples. Phylum Firmicutes had an average proportion of 40%. The proportions of some phyla and genera associated with disease or health also varied dramatically, including Proteobacteria, Actinobacteria, and Faecalibacteria. The core microbiota of elderly subjects was distinct from that previously established for younger adults, with a greater proportion of Bacteroides spp. and distinct abundance patterns of Clostridium groups. Analyses of 26 fecal microbiota datasets from 3-month follow-up samples indicated that in 85% of the subjects, the microbiota composition was more like the corresponding time-0 sample than any other dataset. We conclude that the fecal microbiota of the elderly shows temporal stability over limited time in the majority of subjects but is characterized by unusual phylum proportions and extreme variability. |
| Author | Claesson, Marcus J van Sinderen, Douwe Marchesi, Julian R Dinan, Timothy O'Mahony, Denis Cusack, Siobhán Fitzgerald, Gerald O'Sullivan, Orla Falush, Daniel Twomey, Cillian Hill, Colin Fitzgerald, Anthony P Ross, R. Paul Flannery, Edel Stanton, Catherine O'Connor, Kieran Greene-Diniz, Rachel Shanahan, Fergus O'Connor, Michael Harnedy, Norma Henry, Colm de Weerd, Heleen O'Toole, Paul W |
| Author_xml | – sequence: 1 fullname: Claesson, Marcus J – sequence: 2 fullname: Cusack, Siobhán – sequence: 3 fullname: O'Sullivan, Orla – sequence: 4 fullname: Greene-Diniz, Rachel – sequence: 5 fullname: de Weerd, Heleen – sequence: 6 fullname: Flannery, Edel – sequence: 7 fullname: Marchesi, Julian R – sequence: 8 fullname: Falush, Daniel – sequence: 9 fullname: Dinan, Timothy – sequence: 10 fullname: Fitzgerald, Gerald – sequence: 11 fullname: Stanton, Catherine – sequence: 12 fullname: van Sinderen, Douwe – sequence: 13 fullname: O'Connor, Michael – sequence: 14 fullname: Harnedy, Norma – sequence: 15 fullname: O'Connor, Kieran – sequence: 16 fullname: Henry, Colm – sequence: 17 fullname: O'Mahony, Denis – sequence: 18 fullname: Fitzgerald, Anthony P – sequence: 19 fullname: Shanahan, Fergus – sequence: 20 fullname: Twomey, Cillian – sequence: 21 fullname: Hill, Colin – sequence: 22 fullname: Ross, R. Paul – sequence: 23 fullname: O'Toole, Paul W |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20571116$$D View this record in MEDLINE/PubMed |
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| Notes | http://dx.doi.org/10.1073/pnas.1000097107 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 Edited by Jeffrey I. Gordon, Washington University School of Medicine, St. Louis, MO, and approved June 1, 2010 (received for review February 5, 2010) Author contributions: J.R.M., T.D., G.F., C.S., D.v.S., D.O., A.P.F., F.S., C. Hill, R.P.R., and P.W.O. designed research; M.J.C., S.C., O.O., R.G.-D., E.F., M.O., N.H., K.O., C. Henry, D.O., A.P.F., and C.T. performed research; H.d.W., M.O., N.H., K.O., C. Henry, D.O., and C.T. contributed new reagents/analytic tools; M.J.C., S.C., O.O., R.G.-D., H.d.W., J.R.M., D.F., T.D., A.P.F., F.S., C.T., C. Hill, R.P.R., and P.W.O. analyzed data; and M.J.C., S.C., J.R.M., G.F., C.S., D.v.S., F.S., C. Hill, R.P.R., and P.W.O. wrote the paper. |
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| SubjectTerms | Actinobacteria Age Factors Aged Aged, 80 and over Antibiotics Bacteria - classification Bacteria - genetics Bacteroides Bacteroidetes Base Sequence Biological Sciences Clostridium Cluster Analysis Colloquium Papers Computational Biology data collection Datasets elderly Feces - microbiology Firmicutes genes Humans infants inflammatory bowel disease Inflammatory bowel diseases intestinal microorganisms Intestines - microbiology Ireland irritable bowel syndrome Metagenome - genetics Microbiota Molecular Sequence Data obesity Older adults Phylogenetics Phylogeny Principal Component Analysis Proportions Proteobacteria ribosomal RNA RNA, Ribosomal, 16S - genetics sequence analysis Sequence Analysis, DNA Species Specificity Statistics, Nonparametric |
| Title | Composition, variability, and temporal stability of the intestinal microbiota of the elderly |
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