Microglia Play a Major Role in Direct Viral-Induced Demyelination

• Published in: Clinical & developmental immunology Vol. 2013; no. 2013; pp. 1 - 12
• Main Authors: Ramachandra, S. G., Nag, Soma, Biswas, Kaushiki, Chatterjee, Dhriti, Das Sarma, Jayasri
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2013; Wiley
• Subjects: Animals; Calcium-Binding Proteins - genetics; Calcium-Binding Proteins - immunology; Central Nervous System - immunology; Central Nervous System - pathology; Central Nervous System - virology; Demyelinating Diseases - immunology; Demyelinating Diseases - pathology; Demyelinating Diseases - virology; Disease Models, Animal; Gene Expression; Humans; Meningoencephalitis - immunology; Meningoencephalitis - pathology; Meningoencephalitis - virology; Mice; Mice, Inbred C57BL; Microfilament Proteins - genetics; Microfilament Proteins - immunology; Microglia - immunology; Microglia - pathology; Microglia - virology; Multiple Sclerosis - immunology; Multiple Sclerosis - pathology; Multiple Sclerosis - virology; Murine hepatitis virus - immunology; Myelin Sheath - immunology; Myelin Sheath - pathology; Myelin Sheath - virology; Myelitis, Transverse - immunology; Myelitis, Transverse - pathology; Myelitis, Transverse - virology; Spinal Cord - immunology; Spinal Cord - pathology; Spinal Cord - virology; Tissue Culture Techniques

Microglia are the resident macrophage-like populations in the central nervous system (CNS). Microglia remain quiescent, unable to perform effector and antigen presentation (APC) functions until activated by injury or infection, and have been suggested to represent the first line of defence for the C...