Chemical Approaches to Stem Cell Biology and Therapeutics

Small molecules that modulate stem cell fate and function offer significant opportunities that will allow the full realization of the therapeutic potential of stem cells. Rational design and screening for small molecules have identified useful compounds to probe fundamental mechanisms of stem cell s...

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Published inCell stem cell Vol. 13; no. 3; pp. 270 - 283
Main Authors Li, Wenlin, Li, Ke, Wei, Wanguo, Ding, Sheng
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 05.09.2013
Subjects
Animals
Cell Differentiation - drug effects
Chemistry, Pharmaceutical
Drug Design
Humans
MAP Kinase Signaling System - drug effects
Molecular Targeted Therapy - trends
Pluripotent Stem Cells - drug effects
Pluripotent Stem Cells - physiology
Pyrazoles - chemistry
Pyrazoles - pharmacology
Pyrazoles - therapeutic use
Pyrimidines - chemistry
Pyrimidines - pharmacology
Pyrimidines - therapeutic use
Regenerative Medicine - trends
Small Molecule Libraries
Wound Healing - drug effects
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Abstract Small molecules that modulate stem cell fate and function offer significant opportunities that will allow the full realization of the therapeutic potential of stem cells. Rational design and screening for small molecules have identified useful compounds to probe fundamental mechanisms of stem cell self-renewal, differentiation, and reprogramming and have facilitated the development of cell-based therapies and therapeutic drugs targeting endogenous stem and progenitor cells for repair and regeneration. Here, we will discuss recent scientific and therapeutic progress, as well as new perspectives and future challenges for using chemical approaches in stem cell biology and regenerative medicine. This Review discusses recent progress in using chemical approaches to probe fundamental mechanisms of stem cell self-renewal, differentiation, and reprogramming and considers future challenges for applications in regenerative medicine.
AbstractList Small molecules that modulate stem cell fate and function offer significant opportunities that will allow the full realization of the therapeutic potential of stem cells. Rational design and screening for small molecules have identified useful compounds to probe fundamental mechanisms of stem cell self-renewal, differentiation, and reprogramming and have facilitated the development of cell-based therapies and therapeutic drugs targeting endogenous stem and progenitor cells for repair and regeneration. Here, we will discuss recent scientific and therapeutic progress, as well as new perspectives and future challenges for using chemical approaches in stem cell biology and regenerative medicine.
Small molecules that modulate stem cell fate and function offer significant opportunities that will allow the full realization of the therapeutic potential of stem cells. Rational design and screening for small molecules have identified useful compounds to probe fundamental mechanisms of stem cell self-renewal, differentiation, and reprogramming and have facilitated the development of cell-based therapies and therapeutic drugs targeting endogenous stem and progenitor cells for repair and regeneration. Here, we will discuss recent scientific and therapeutic progress, as well as new perspectives and future challenges for using chemical approaches in stem cell biology and regenerative medicine. This Review discusses recent progress in using chemical approaches to probe fundamental mechanisms of stem cell self-renewal, differentiation, and reprogramming and considers future challenges for applications in regenerative medicine.
Author Li, Wenlin
Ding, Sheng
Wei, Wanguo
Li, Ke
AuthorAffiliation 2 Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, 94158, USA
1 Department of Cell Biology, Second Military Medical University, Shanghai 200433, China
3 Stem Cell and Regenerative Medicine Center, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China
AuthorAffiliation_xml – name: 2 Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, 94158, USA
– name: 3 Stem Cell and Regenerative Medicine Center, Shanghai Advanced Research Institute, Chinese Academy of Science, Shanghai 201210, China
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Author_xml – sequence: 1
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– sequence: 2
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  surname: Li
  fullname: Li, Ke
  organization: Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA
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  givenname: Wanguo
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  surname: Ding
  fullname: Ding, Sheng
  email: sheng.ding@gladstone.ucsf.edu
  organization: Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA
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Snippet Small molecules that modulate stem cell fate and function offer significant opportunities that will allow the full realization of the therapeutic potential of...
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SubjectTerms Animals
Cell Differentiation - drug effects
Chemistry, Pharmaceutical
Drug Design
Humans
MAP Kinase Signaling System - drug effects
Molecular Targeted Therapy - trends
Pluripotent Stem Cells - drug effects
Pluripotent Stem Cells - physiology
Pyrazoles - chemistry
Pyrazoles - pharmacology
Pyrazoles - therapeutic use
Pyrimidines - chemistry
Pyrimidines - pharmacology
Pyrimidines - therapeutic use
Regenerative Medicine - trends
Small Molecule Libraries
Wound Healing - drug effects
Title Chemical Approaches to Stem Cell Biology and Therapeutics
URI https://dx.doi.org/10.1016/j.stem.2013.08.002
https://www.ncbi.nlm.nih.gov/pubmed/24012368
https://search.proquest.com/docview/1431294258
https://search.proquest.com/docview/1560124519
https://pubmed.ncbi.nlm.nih.gov/PMC3898630
Volume 13
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