Long-term clinical significance of frequent and complex ventricular tachyarrhythmias in trained athletes

• Published in: Journal of the American College of Cardiology Vol. 40; no. 3; pp. 446 - 452
• Main Authors: Biffi, Alessandro, Pelliccia, Antonio, Verdile, Luisa, Fernando, Fredrick, Spataro, Antonio, Caselli, Stefano, Santini, Massimo, Maron, Barry J
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.08.2002; Elsevier Limited
• Subjects: Adolescent; Adrenergic beta-Antagonists - therapeutic use; Adult; Anti-Arrhythmia Agents - therapeutic use; Cardiac arrhythmia; Cardiology; Cardiomyopathy; Cardiovascular Abnormalities - diagnosis; Cardiovascular Abnormalities - drug therapy; Cardiovascular Abnormalities - epidemiology; Cardiovascular disease; Circadian Rhythm - physiology; Colleges & universities; Electrocardiography, Ambulatory; Electrophysiologic Techniques, Cardiac; Enalapril - therapeutic use; Family medical history; Female; Follow-Up Studies; Heart; Heart attacks; Heart Rate - physiology; Humans; Italy - epidemiology; Male; NMR; Nuclear magnetic resonance; Population; Prevalence; Propafenone - therapeutic use; Severity of Illness Index; Sports; Tachycardia - diagnosis; Tachycardia - drug therapy; Tachycardia - epidemiology; Time Factors; Italy; United States > US; California; ARVC; LBBB; MRI; NSVT; ECG; EP; VA; VT; PVD
• DOI: 10.1016/S0735-1097(02)01977-0
• ISSN: 0735-1097

The aim of this study was to clarify the clinical relevance of ventricular tachyarrhythmias assessed by 24-h ambulatory electrocardiograms (ECG) in a large, unique, and prospectively evaluated athletic population. For athletes with ventricular tachyarrhythmias, the risk of sudden cardiac death associated with participation in competitive sports is unresolved. We assessed 355 competitive athletes with ventricular arrhythmias (VAs) on a 24-h ambulatory (Holter) ECG that was obtained because of either palpitations, the presence of ≥3 premature ventricular depolarizations (PVDs) on resting 12-lead ECG, or both. Athletes were segregated into three groups: Group A with ≥2,000 PVDs/24 h (n = 71); Group B with ≥100 <2,000 PVDs/24 h (n = 153); and Group C with only <100 PVDs/24 h (n = 131). Cardiac abnormalities were detected in 26 of the 355 study subjects (7%) and were significantly more common in Group A (21/71, 30%) than in Group B (5/153, 3%) or Group C athletes (0/131, 0% p < 0.001). Only the 71 athletes in Group A were excluded from competition. During follow-up (mean, 8 years), 70 of 71 athletes in Group A and each of the 284 athletes in Groups B and C have survived without cardiovascular events. The remaining Group A athlete died suddenly of arrhythmogenic right ventricular cardiomyopathy while participating in a field hockey game against medical advice. Frequent and complex ventricular tachyarrhythmias are common in trained athletes and are usually unassociated with underlying cardiovascular abnormalities. Such VAs (when unassociated with cardiovascular abnormalities) do not convey adverse clinical significance, appear to be an expression of “athlete’s heart syndrome,” and probably do not per se justify a disqualification from competitive sports.