Insulin regulates POMC neuronal plasticity to control glucose metabolism

• Published in: eLife Vol. 7
• Main Authors: Dodd, Garron T, Michael, Natalie J, Lee-Young, Robert S, Mangiafico, Salvatore P, Pryor, Jack T, Munder, Astrid C, Simonds, Stephanie E, Brüning, Jens Claus, Zhang, Zhong-Yin, Cowley, Michael A, Andrikopoulos, Sofianos, Horvath, Tamas L, Spanswick, David, Tiganis, Tony
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 19.09.2018; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Animals; Biochemistry; Brain; cellular signalling; Diabetes therapy; Excitability; Fasting; Feeding; Gene expression; Genes; Glucose; Glucose - metabolism; Human Biology and Medicine; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - pharmacology; Hypothalamus; Hypothalamus - cytology; Insulin; Insulin - administration & dosage; Insulin - pharmacology; Insulin resistance; Kinases; Male; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neuronal Plasticity - drug effects; Neuronal Plasticity - genetics; Neurons; Neurons - metabolism; Neuroscience; Nutrient deficiency; Obesity; Phosphatases; Physiological aspects; Plasticity (neural); POMC neurons; Pro-Opiomelanocortin - genetics; Pro-Opiomelanocortin - metabolism; Proopiomelanocortin; protein tyrosine phosphatase; Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism; Receptor, Insulin - genetics; Receptor, Insulin - metabolism; Rodents; Victoria Australia; Cologne Germany; United Kingdom > UK; Australia; United States > US; human biology; cellular signalling; mouse; insulin; neuroscience; protein tyrosine phosphatase; medicine; POMC neurons; glucose metabolism; hypothalamus

Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activated or inhibited by insulin and thereby repress or inhibit hep...