Insulin regulates POMC neuronal plasticity to control glucose metabolism

Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activated or inhibited by insulin and thereby repress or inhibit hep...

Full description

Saved in:
Bibliographic Details
Published ineLife Vol. 7
Main Authors Dodd, Garron T, Michael, Natalie J, Lee-Young, Robert S, Mangiafico, Salvatore P, Pryor, Jack T, Munder, Astrid C, Simonds, Stephanie E, Brüning, Jens Claus, Zhang, Zhong-Yin, Cowley, Michael A, Andrikopoulos, Sofianos, Horvath, Tamas L, Spanswick, David, Tiganis, Tony
Format Journal Article
LanguageEnglish
Published England eLife Science Publications, Ltd 19.09.2018
eLife Sciences Publications Ltd
eLife Sciences Publications, Ltd
Subjects
Animals
Biochemistry
Brain
cellular signalling
Diabetes therapy
Excitability
Fasting
Feeding
Gene expression
Genes
Glucose
Glucose - metabolism
Human Biology and Medicine
Humans
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - pharmacology
Hypothalamus
Hypothalamus - cytology
Insulin
Insulin - administration & dosage
Insulin - pharmacology
Insulin resistance
Kinases
Male
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Neuronal Plasticity - drug effects
Neuronal Plasticity - genetics
Neurons
Neurons - metabolism
Neuroscience
Nutrient deficiency
Obesity
Phosphatases
Physiological aspects
Plasticity (neural)
POMC neurons
Pro-Opiomelanocortin - genetics
Pro-Opiomelanocortin - metabolism
Proopiomelanocortin
protein tyrosine phosphatase
Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics
Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism
Receptor, Insulin - genetics
Receptor, Insulin - metabolism
Rodents
Victoria Australia
Cologne Germany
United Kingdom > UK
Australia
United States > US
human biology
cellular signalling
mouse
insulin
neuroscience
protein tyrosine phosphatase
medicine
POMC neurons
glucose metabolism
hypothalamus
Online AccessGet full text

Cover

Abstract Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activated or inhibited by insulin and thereby repress or inhibit hepatic glucose production (HGP). The proportion of POMC neurons activated by insulin was dependent on the regulation of insulin receptor signaling by the phosphatase TCPTP, which is increased by fasting, degraded after feeding and elevated in diet-induced obesity. TCPTP-deficiency enhanced insulin signaling and the proportion of POMC neurons activated by insulin to repress HGP. Elevated TCPTP in POMC neurons in obesity and/or after fasting repressed insulin signaling, the activation of POMC neurons by insulin and the insulin-induced and POMC-mediated repression of HGP. Our findings define a molecular mechanism for integrating POMC neural responses with feeding to control glucose metabolism.
AbstractList Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes remain unclear. Here we define populations of POMC neurons in mice that are activated or inhibited by insulin and thereby repress or inhibit hepatic glucose production (HGP). The proportion of POMC neurons activated by insulin was dependent on the regulation of insulin receptor signaling by the phosphatase TCPTP, which is increased by fasting, degraded after feeding and elevated in diet-induced obesity. TCPTP-deficiency enhanced insulin signaling and the proportion of POMC neurons activated by insulin to repress HGP. Elevated TCPTP in POMC neurons in obesity and/or after fasting repressed insulin signaling, the activation of POMC neurons by insulin and the insulin-induced and POMC-mediated repression of HGP. Our findings define a molecular mechanism for integrating POMC neural responses with feeding to control glucose metabolism.
Audience Academic
Author Zhang, Zhong-Yin
Horvath, Tamas L
Tiganis, Tony
Mangiafico, Salvatore P
Brüning, Jens Claus
Simonds, Stephanie E
Munder, Astrid C
Andrikopoulos, Sofianos
Spanswick, David
Dodd, Garron T
Lee-Young, Robert S
Michael, Natalie J
Cowley, Michael A
Pryor, Jack T
Author_xml – sequence: 1
  givenname: Garron T
  orcidid: 0000-0002-7554-4876
  surname: Dodd
  fullname: Dodd, Garron T
  organization: Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
– sequence: 2
  givenname: Natalie J
  orcidid: 0000-0002-9032-0862
  surname: Michael
  fullname: Michael, Natalie J
  organization: Department of Physiology, Monash University, Victoria, Australia
– sequence: 3
  givenname: Robert S
  surname: Lee-Young
  fullname: Lee-Young, Robert S
  organization: Monash Metabolic Phenotyping Facility, Monash University, Victoria, Australia
– sequence: 4
  givenname: Salvatore P
  surname: Mangiafico
  fullname: Mangiafico, Salvatore P
  organization: Department of Medicine (Austin Hospital), The University of Melbourne, Melbourne, Australia
– sequence: 5
  givenname: Jack T
  surname: Pryor
  fullname: Pryor, Jack T
  organization: Warwick Medical School, University of Warwick, Coventry, United Kingdom
– sequence: 6
  givenname: Astrid C
  surname: Munder
  fullname: Munder, Astrid C
  organization: Department of Physiology, Monash University, Victoria, Australia
– sequence: 7
  givenname: Stephanie E
  surname: Simonds
  fullname: Simonds, Stephanie E
  organization: Department of Physiology, Monash University, Victoria, Australia
– sequence: 8
  givenname: Jens Claus
  surname: Brüning
  fullname: Brüning, Jens Claus
  organization: National Center for Diabetes Research, Neuherberg, Germany
– sequence: 9
  givenname: Zhong-Yin
  surname: Zhang
  fullname: Zhang, Zhong-Yin
  organization: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, United States
– sequence: 10
  givenname: Michael A
  surname: Cowley
  fullname: Cowley, Michael A
  organization: Department of Physiology, Monash University, Victoria, Australia
– sequence: 11
  givenname: Sofianos
  surname: Andrikopoulos
  fullname: Andrikopoulos, Sofianos
  organization: Department of Medicine (Austin Hospital), The University of Melbourne, Melbourne, Australia
– sequence: 12
  givenname: Tamas L
  orcidid: 0000-0002-7522-4602
  surname: Horvath
  fullname: Horvath, Tamas L
  organization: Department of Anatomy and Histology, University of Veterinary Medicine, Hungary, Europe
– sequence: 13
  givenname: David
  surname: Spanswick
  fullname: Spanswick, David
  organization: Warwick Medical School, University of Warwick, Coventry, United Kingdom
– sequence: 14
  givenname: Tony
  orcidid: 0000-0002-8065-9942
  surname: Tiganis
  fullname: Tiganis, Tony
  organization: Monash Metabolic Phenotyping Facility, Monash University, Victoria, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30230471$$D View this record in MEDLINE/PubMed
BookMark eNpdks1vFCEYh4mpsXXtybuZxIuN2QrD51xMmk21m6yp0R68EQbeGdmwwxZmjP3vZbu1duUCgScPvC-_l-hoiAMg9Jrgc8k5-wDBd3BOlcTsGTqpMcdzrNiPoyfrY3Sa8xqXIZlSpHmBjimuKWaSnKCr5ZCn4IcqQT8FM0Kuvl5_WVQDTCkOJlTbYPLorR_vqjFWNg5jiqHqw2RjhmoDo2lj8HnzCj3vTMhw-jDP0M2ny5vF1Xx1_Xm5uFjNrcB0nFMLmLKWghU1wS2nmDeUMSk5MExaoZxltJa4bQUw56AjhSfKUGcdVg2doeVe66JZ623yG5PudDRe32_E1GuTynsD6M4Uh1NOACEMjGhr40xDOCWNoKS8ZoY-7l3bqd2As1BqM-FAengy-J-6j7-0IBITpYrg3YMgxdsJ8qg3PlsIwQwQp6xrQgSplVSyoG__Q9dxSqXBO6qWXNZcqn9Ub0oBfuhiudfupPqCN6IhpU-8UGcH1O5T4PfYmylnvfz-7ZB9v2dtijkn6B7LI1jvEqRhVRKk7xNU6DdPO_LI_s0L_QPxG8F_
CitedBy_id crossref_primary_10_1186_s13578_022_00907_2
crossref_primary_10_1111_jne_13344
crossref_primary_10_1152_ajpheart_00411_2020
crossref_primary_10_3390_ijms22052728
crossref_primary_10_1016_j_celrep_2019_08_019
crossref_primary_10_1016_j_jnutbio_2023_109372
crossref_primary_10_31857_S086981392302005X
crossref_primary_10_1007_s12035_023_03698_w
crossref_primary_10_1111_jne_12937
crossref_primary_10_1111_jne_12939
crossref_primary_10_3390_cells11131996
crossref_primary_10_1016_j_neuroscience_2020_09_045
crossref_primary_10_1016_j_jlr_2023_100368
crossref_primary_10_3389_fncir_2020_595783
crossref_primary_10_1016_j_biochi_2022_09_006
crossref_primary_10_3389_fendo_2022_877647
crossref_primary_10_1038_s41392_022_01149_x
crossref_primary_10_3389_fnins_2022_828571
crossref_primary_10_15252_embr_201947903
crossref_primary_10_1016_j_ejphar_2022_174956
crossref_primary_10_1016_j_molmet_2021_101206
crossref_primary_10_1038_s42255_021_00345_3
crossref_primary_10_1002_jcp_30779
crossref_primary_10_1016_j_ejphar_2021_174611
crossref_primary_10_1126_sciadv_abf4100
crossref_primary_10_1016_j_tins_2022_03_001
crossref_primary_10_1038_s41467_020_20160_w
crossref_primary_10_1210_clinem_dgab421
crossref_primary_10_1530_JOE_18_0596
crossref_primary_10_1038_s42255_024_00987_z
crossref_primary_10_1093_function_zqad070
crossref_primary_10_1111_cpr_13332
crossref_primary_10_1038_s41467_021_22431_6
crossref_primary_10_1093_cercor_bhad358
crossref_primary_10_1016_j_isci_2023_107063
crossref_primary_10_1152_ajpendo_00642_2020
crossref_primary_10_3389_fcell_2022_979251
crossref_primary_10_1007_s40618_024_02411_5
crossref_primary_10_1016_S2213_8587_20_30113_3
crossref_primary_10_20900_agmr20230005
crossref_primary_10_1016_j_molmet_2019_06_001
crossref_primary_10_1038_s41573_020_0072_x
crossref_primary_10_1111_jne_12952
crossref_primary_10_1038_s41398_020_01126_4
crossref_primary_10_3389_fendo_2022_889122
crossref_primary_10_1016_j_celrep_2020_02_029
crossref_primary_10_3390_ijms24010543
crossref_primary_10_1016_j_molmet_2021_101234
crossref_primary_10_1134_S0022093023010210
crossref_primary_10_3390_plants10050837
crossref_primary_10_12688_f1000research_152034_1
crossref_primary_10_3390_ijms20061317
crossref_primary_10_1186_s13036_019_0194_z
crossref_primary_10_7554_eLife_59616
crossref_primary_10_1111_jnc_15314
crossref_primary_10_1155_2019_7210892
crossref_primary_10_1038_s41467_023_42595_7
crossref_primary_10_1016_j_brainres_2022_147901
crossref_primary_10_1159_000506367
crossref_primary_10_1111_jne_13392
crossref_primary_10_1016_j_molmet_2020_01_002
crossref_primary_10_1186_s13578_022_00853_z
crossref_primary_10_3390_cells12131801
crossref_primary_10_3389_fphys_2020_00553
crossref_primary_10_1152_jn_00359_2020
crossref_primary_10_1016_j_yfrne_2021_100944
crossref_primary_10_14336_AD_2023_0814
crossref_primary_10_1016_j_neuroscience_2019_09_031
crossref_primary_10_1111_jne_12947
crossref_primary_10_1210_endrev_bnab025
crossref_primary_10_1038_s41574_023_00885_6
crossref_primary_10_1038_s41573_022_00618_w
crossref_primary_10_1016_j_tem_2022_01_004
crossref_primary_10_1159_000501560
crossref_primary_10_1016_j_molmet_2020_101084
Cites_doi 10.1016/j.cmet.2011.09.011
10.1038/35078085
10.1016/j.tips.2015.07.003
10.2337/db17-1485
10.1038/nm1201
10.1016/j.cmet.2014.03.004
10.1172/JCI32964
10.2337/db16-1238
10.1523/JNEUROSCI.4816-09.2010
10.1016/j.cmet.2005.11.013
10.1016/j.cell.2011.07.039
10.2337/db06-0376
10.1016/j.molmet.2017.02.007
10.1016/j.neuron.2009.06.014
10.1523/JNEUROSCI.3118-09.2010
10.1016/j.neuron.2011.05.028
10.1038/nrendo.2014.160
10.1038/nm.2126
10.1073/pnas.0604404103
10.1021/ja903733z
10.1038/nature03439
10.2337/db07-0532
10.7554/eLife.33710
10.1016/j.cmet.2007.05.004
10.1016/j.cmet.2009.08.009
10.1016/j.cell.2013.09.004
10.1016/j.cell.2014.12.022
10.1210/en.2005-1498
10.1016/j.celrep.2017.03.004
10.1038/nm1775
10.2337/db13-0340
10.1016/S0896-6273(01)80035-0
10.1016/j.cell.2016.02.044
10.1016/S1097-2765(00)80155-0
10.1038/nm1202-798
10.1126/science.289.5487.2122
10.1016/j.tem.2012.11.004
10.1038/nature11270
10.2337/db14-0477
10.1038/nn.2167
10.1038/nn0602-861
10.1016/j.cmet.2017.08.001
10.7554/eLife.09800
10.1016/j.cmet.2010.03.002
10.1038/nature06098
10.1111/jne.12501
10.1016/S0896-6273(03)00063-1
10.1038/s41586-018-0049-7
10.1016/j.cell.2014.01.008
10.1111/j.1742-4658.2012.08563.x
10.1172/JCI31516
10.1172/JCI27123
10.1016/j.neuron.2004.06.004
10.1016/j.cell.2013.09.003
10.1002/1526-968X(200011/12)28:3/4<147::AID-GENE90>3.0.CO;2-G
10.1016/j.celrep.2016.02.032
10.1038/nm980
10.1172/JCI46229
10.1073/pnas.0700293104
10.2337/db16-1380
10.1038/272827a0
10.1073/pnas.1004282107
10.1038/77660
10.1038/nn1226
10.1038/embor.2012.174
10.2337/db10-0940
10.1038/nn1550
10.1038/nn.2703
10.1172/JCI59816
10.1016/j.cmet.2006.02.009
10.1038/nn.4495
10.1126/science.1089459
10.1016/j.tins.2012.12.005
ContentType Journal Article
Copyright 2018, Dodd et al.
COPYRIGHT 2018 eLife Science Publications, Ltd.
2018, Dodd et al. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2018, Dodd et al 2018 Dodd et al
Copyright_xml – notice: 2018, Dodd et al.
– notice: COPYRIGHT 2018 eLife Science Publications, Ltd.
– notice: 2018, Dodd et al. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2018, Dodd et al 2018 Dodd et al
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
ISR
3V.
7X7
7XB
88E
88I
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOA
DOI 10.7554/elife.38704
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Science in Context
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
ProQuest Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Science Database (ProQuest)
Biological Science Database
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
Publicly Available Content Database
MEDLINE - Academic
CrossRef
MEDLINE
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
EISSN 2050-084X
ExternalDocumentID oai_doaj_org_article_fab6ed8d6e114ea6b2ada91531963160
A596917755
10_7554_eLife_38704
30230471
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GeographicLocations Victoria Australia
Cologne Germany
United Kingdom--UK
Australia
United States--US
GeographicLocations_xml – name: Cologne Germany
– name: Victoria Australia
– name: United Kingdom--UK
– name: United States--US
– name: Australia
GrantInformation_xml – fundername: NIA NIH HHS
  grantid: R56 AG052986
– fundername: NIH HHS
  grantid: RO1 CA207288
– fundername: NIA NIH HHS
  grantid: R01 AG052986
– fundername: NIA NIH HHS
  grantid: P01 AG051459
– fundername: NIH HHS
  grantid: AG052986
– fundername: NIH HHS
  grantid: AG051459
– fundername: NIDDK NIH HHS
  grantid: R01 DK111178
– fundername: NIH HHS
  grantid: DK111178
– fundername: NCI NIH HHS
  grantid: R01 CA207288
– fundername: ;
– fundername: ;
  grantid: AG052986
– fundername: ;
  grantid: RO1 CA207288
– fundername: ;
  grantid: AG051459
– fundername: ;
  grantid: DK111178
GroupedDBID 3V.
53G
5VS
7X7
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAKDD
ABUWG
ACGFO
ACGOD
ACPRK
ADBBV
ADRAZ
AENEX
AFKRA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
CCPQU
CGR
CUY
CVF
DIK
DWQXO
ECM
EIF
EMOBN
FRP
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HYE
IAO
IEA
IHR
INH
INR
ISR
ITC
KQ8
LK8
M1P
M2P
M48
M7P
M~E
NPM
NQS
OK1
PGMZT
PIMPY
PQQKQ
PROAC
PSQYO
RHF
RHI
RNS
RPM
UKHRP
AAYXX
CITATION
AFPKN
7XB
8FK
K9.
PQEST
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c603t-3ce034b3ec6210b53059344775e401b68dc43270bb6e4ddef1e0318a3dcd0893
IEDL.DBID RPM
ISSN 2050-084X
IngestDate Tue Oct 22 15:07:33 EDT 2024
Tue Sep 17 21:24:00 EDT 2024
Fri Oct 25 05:21:49 EDT 2024
Sat Nov 16 02:25:51 EST 2024
Tue Nov 19 21:02:10 EST 2024
Thu Aug 01 19:11:56 EDT 2024
Fri Dec 06 04:30:53 EST 2024
Wed Oct 16 00:50:56 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords human biology
cellular signalling
mouse
insulin
neuroscience
protein tyrosine phosphatase
medicine
POMC neurons
glucose metabolism
hypothalamus
Language English
License 2018, Dodd et al.
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c603t-3ce034b3ec6210b53059344775e401b68dc43270bb6e4ddef1e0318a3dcd0893
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work.
ORCID 0000-0002-8065-9942
0000-0002-7554-4876
0000-0002-9032-0862
0000-0002-7522-4602
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170188/
PMID 30230471
PQID 2127572578
PQPubID 2045579
ParticipantIDs doaj_primary_oai_doaj_org_article_fab6ed8d6e114ea6b2ada91531963160
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6170188
proquest_miscellaneous_2116128787
proquest_journals_2127572578
gale_infotracmisc_A596917755
gale_incontextgauss_ISR_A596917755
crossref_primary_10_7554_eLife_38704
pubmed_primary_30230471
PublicationCentury 2000
PublicationDate 2018-09-19
PublicationDateYYYYMMDD 2018-09-19
PublicationDate_xml – month: 09
  year: 2018
  text: 2018-09-19
  day: 19
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: Cambridge
PublicationTitle eLife
PublicationTitleAlternate Elife
PublicationYear 2018
Publisher eLife Science Publications, Ltd
eLife Sciences Publications Ltd
eLife Sciences Publications, Ltd
Publisher_xml – name: eLife Science Publications, Ltd
– name: eLife Sciences Publications Ltd
– name: eLife Sciences Publications, Ltd
References Tong (bib62) 2008; 11
Campbell (bib10) 2017; 20
Parra (bib48) 2014; 63
Zhang (bib72) 2009; 131
Anthony (bib2) 2006; 55
Padilla (bib47) 2010; 16
Armbruster (bib3) 2007; 104
Vong (bib68) 2011; 71
Inoue (bib34) 2006; 3
Shin (bib57) 2017; 66
Gelling (bib24) 2006; 3
Henry (bib28) 2015; 4
Qiu (bib55) 2018; 30
Havrankova (bib25) 1978; 272
Parton (bib49) 2007; 449
Vogt (bib67) 2014; 156
Spanswick (bib58) 2000; 3
van den Top (bib64) 2004; 7
Tschritter (bib63) 2006; 103
Claret (bib13) 2007; 117
Horvath (bib32) 2010; 107
Pinto (bib50) 2004; 304
Schneeberger (bib56) 2013; 155
Lam (bib38) 2005; 11
Atasoy (bib4) 2012; 488
Brüning (bib7) 1998; 2
Dodd (bib18) 2015; 160
Elias (bib21) 1999; 23
Yang (bib71) 2011; 146
Heni (bib27) 2017; 66
Vogt (bib66) 2013; 24
Buettner (bib9) 2008; 14
Dodd (bib20) 2018; 67
Lam (bib39) 2017; 6
Zhang (bib73) 2015; 36
Fueger (bib23) 2007; 56
Plum (bib51) 2006; 116
Berglund (bib6) 2012; 122
Nasrallah (bib43) 2014; 10
Dietrich (bib17) 2013; 155
Hill (bib29) 2008; 118
Obici (bib45) 2002; 5
Xu (bib70) 2018; 556
Steculorum (bib59) 2016; 165
Hirvonen (bib31) 2011; 60
Inoue (bib33) 2004; 10
Balthasar (bib5) 2004; 42
Krashes (bib37) 2011; 121
Heni (bib26) 2014; 63
Novak (bib44) 2000; 28
Könner (bib36) 2007; 5
Ferguson (bib22) 2011; 14
Qiu (bib53) 2010; 30
Loh (bib41) 2009; 10
Varela (bib65) 2012; 13
Qiu (bib54) 2014; 19
Kimura (bib35) 2016; 14
Sternson (bib60) 2005; 8
Dietrich (bib16) 2013; 36
Pocai (bib52) 2005; 434
Cowley (bib15) 2003; 37
Dodd (bib19) 2017; 26
Lamont (bib40) 2006; 147
Caron (bib11) 2018; 7
Obici (bib46) 2002; 8
Hill (bib30) 2010; 11
Williams (bib69) 2010; 30
Chen (bib12) 2017; 18
Tiganis (bib61) 2013; 280
Cowley (bib14) 2001; 411
Loh (bib42) 2011; 14
Alexander (bib1) 2009; 63
Brüning (bib8) 2000; 289
References_xml – volume: 14
  start-page: 684
  year: 2011
  ident: bib42
  article-title: Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance
  publication-title: Cell Metabolism
  doi: 10.1016/j.cmet.2011.09.011
  contributor:
    fullname: Loh
– volume: 411
  start-page: 480
  year: 2001
  ident: bib14
  article-title: Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
  publication-title: Nature
  doi: 10.1038/35078085
  contributor:
    fullname: Cowley
– volume: 36
  start-page: 661
  year: 2015
  ident: bib73
  article-title: Protein tyrosine phosphatases in hypothalamic insulin and leptin signaling
  publication-title: Trends in Pharmacological Sciences
  doi: 10.1016/j.tips.2015.07.003
  contributor:
    fullname: Zhang
– volume: 67
  start-page: 1246
  year: 2018
  ident: bib20
  article-title: TCPTP regulates insulin signaling in AgRP neurons to coordinate glucose metabolism with feeding
  publication-title: Diabetes
  doi: 10.2337/db17-1485
  contributor:
    fullname: Dodd
– volume: 11
  start-page: 320
  year: 2005
  ident: bib38
  article-title: Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
  publication-title: Nature Medicine
  doi: 10.1038/nm1201
  contributor:
    fullname: Lam
– volume: 19
  start-page: 682
  year: 2014
  ident: bib54
  article-title: Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels
  publication-title: Cell Metabolism
  doi: 10.1016/j.cmet.2014.03.004
  contributor:
    fullname: Qiu
– volume: 118
  start-page: 1796
  year: 2008
  ident: bib29
  article-title: Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
  publication-title: Journal of Clinical Investigation
  doi: 10.1172/JCI32964
  contributor:
    fullname: Hill
– volume: 66
  start-page: 1560
  year: 2017
  ident: bib57
  article-title: Insulin receptor signaling in POMC, but not AgRP, neurons controls adipose tissue insulin action
  publication-title: Diabetes
  doi: 10.2337/db16-1238
  contributor:
    fullname: Shin
– volume: 30
  start-page: 1560
  year: 2010
  ident: bib53
  article-title: Leptin excites proopiomelanocortin neurons via activation of TRPC channels
  publication-title: Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.4816-09.2010
  contributor:
    fullname: Qiu
– volume: 3
  start-page: 67
  year: 2006
  ident: bib24
  article-title: Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes
  publication-title: Cell Metabolism
  doi: 10.1016/j.cmet.2005.11.013
  contributor:
    fullname: Gelling
– volume: 146
  start-page: 992
  year: 2011
  ident: bib71
  article-title: Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop
  publication-title: Cell
  doi: 10.1016/j.cell.2011.07.039
  contributor:
    fullname: Yang
– volume: 55
  start-page: 2986
  year: 2006
  ident: bib2
  article-title: Attenuation of insulin-evoked responses in brain networks controlling appetite and reward in insulin resistance: the cerebral basis for impaired control of food intake in metabolic syndrome?
  publication-title: Diabetes
  doi: 10.2337/db06-0376
  contributor:
    fullname: Anthony
– volume: 6
  start-page: 383
  year: 2017
  ident: bib39
  article-title: Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing
  publication-title: Molecular Metabolism
  doi: 10.1016/j.molmet.2017.02.007
  contributor:
    fullname: Lam
– volume: 63
  start-page: 27
  year: 2009
  ident: bib1
  article-title: Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors
  publication-title: Neuron
  doi: 10.1016/j.neuron.2009.06.014
  contributor:
    fullname: Alexander
– volume: 30
  start-page: 2472
  year: 2010
  ident: bib69
  article-title: Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
  publication-title: Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.3118-09.2010
  contributor:
    fullname: Williams
– volume: 71
  start-page: 142
  year: 2011
  ident: bib68
  article-title: Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.05.028
  contributor:
    fullname: Vong
– volume: 10
  start-page: 650
  year: 2014
  ident: bib43
  article-title: Mitochondrial dynamics in the central regulation of metabolism
  publication-title: Nature Reviews Endocrinology
  doi: 10.1038/nrendo.2014.160
  contributor:
    fullname: Nasrallah
– volume: 16
  start-page: 403
  year: 2010
  ident: bib47
  article-title: Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits
  publication-title: Nature Medicine
  doi: 10.1038/nm.2126
  contributor:
    fullname: Padilla
– volume: 103
  start-page: 12103
  year: 2006
  ident: bib63
  article-title: The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study
  publication-title: PNAS
  doi: 10.1073/pnas.0604404103
  contributor:
    fullname: Tschritter
– volume: 131
  start-page: 13072
  year: 2009
  ident: bib72
  article-title: Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy
  publication-title: Journal of the American Chemical Society
  doi: 10.1021/ja903733z
  contributor:
    fullname: Zhang
– volume: 434
  start-page: 1026
  year: 2005
  ident: bib52
  article-title: Hypothalamic K(ATP) channels control hepatic glucose production
  publication-title: Nature
  doi: 10.1038/nature03439
  contributor:
    fullname: Pocai
– volume: 56
  start-page: 2476
  year: 2007
  ident: bib23
  article-title: Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II
  publication-title: Diabetes
  doi: 10.2337/db07-0532
  contributor:
    fullname: Fueger
– volume: 7
  year: 2018
  ident: bib11
  article-title: POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels
  publication-title: eLife
  doi: 10.7554/eLife.33710
  contributor:
    fullname: Caron
– volume: 5
  start-page: 438
  year: 2007
  ident: bib36
  article-title: Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
  publication-title: Cell Metabolism
  doi: 10.1016/j.cmet.2007.05.004
  contributor:
    fullname: Könner
– volume: 10
  start-page: 260
  year: 2009
  ident: bib41
  article-title: Reactive oxygen species enhance insulin sensitivity
  publication-title: Cell Metabolism
  doi: 10.1016/j.cmet.2009.08.009
  contributor:
    fullname: Loh
– volume: 155
  start-page: 188
  year: 2013
  ident: bib17
  article-title: Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity
  publication-title: Cell
  doi: 10.1016/j.cell.2013.09.004
  contributor:
    fullname: Dietrich
– volume: 160
  start-page: 88
  year: 2015
  ident: bib18
  article-title: Leptin and insulin act on POMC neurons to promote the browning of white fat
  publication-title: Cell
  doi: 10.1016/j.cell.2014.12.022
  contributor:
    fullname: Dodd
– volume: 147
  start-page: 2764
  year: 2006
  ident: bib40
  article-title: Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis
  publication-title: Endocrinology
  doi: 10.1210/en.2005-1498
  contributor:
    fullname: Lamont
– volume: 18
  start-page: 3227
  year: 2017
  ident: bib12
  article-title: Single-Cell RNA-Seq reveals hypothalamic cell diversity
  publication-title: Cell Reports
  doi: 10.1016/j.celrep.2017.03.004
  contributor:
    fullname: Chen
– volume: 14
  start-page: 667
  year: 2008
  ident: bib9
  article-title: Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms
  publication-title: Nature Medicine
  doi: 10.1038/nm1775
  contributor:
    fullname: Buettner
– volume: 63
  start-page: 75
  year: 2014
  ident: bib48
  article-title: Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway
  publication-title: Diabetes
  doi: 10.2337/db13-0340
  contributor:
    fullname: Parra
– volume: 23
  start-page: 775
  year: 1999
  ident: bib21
  article-title: Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
  publication-title: Neuron
  doi: 10.1016/S0896-6273(01)80035-0
  contributor:
    fullname: Elias
– volume: 165
  start-page: 125
  year: 2016
  ident: bib59
  article-title: AgRP neurons control systemic insulin sensitivity via myostatin expression in Brown adipose tissue
  publication-title: Cell
  doi: 10.1016/j.cell.2016.02.044
  contributor:
    fullname: Steculorum
– volume: 2
  start-page: 559
  year: 1998
  ident: bib7
  article-title: A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
  publication-title: Molecular Cell
  doi: 10.1016/S1097-2765(00)80155-0
  contributor:
    fullname: Brüning
– volume: 8
  start-page: 1376
  year: 2002
  ident: bib46
  article-title: Hypothalamic insulin signaling is required for inhibition of glucose production
  publication-title: Nature Medicine
  doi: 10.1038/nm1202-798
  contributor:
    fullname: Obici
– volume: 289
  start-page: 2122
  year: 2000
  ident: bib8
  article-title: Role of brain insulin receptor in control of body weight and reproduction
  publication-title: Science
  doi: 10.1126/science.289.5487.2122
  contributor:
    fullname: Brüning
– volume: 24
  start-page: 76
  year: 2013
  ident: bib66
  article-title: CNS insulin signaling in the control of energy homeostasis and glucose metabolism - from embryo to old age
  publication-title: Trends in Endocrinology & Metabolism
  doi: 10.1016/j.tem.2012.11.004
  contributor:
    fullname: Vogt
– volume: 488
  start-page: 172
  year: 2012
  ident: bib4
  article-title: Deconstruction of a neural circuit for hunger
  publication-title: Nature
  doi: 10.1038/nature11270
  contributor:
    fullname: Atasoy
– volume: 63
  start-page: 4083
  year: 2014
  ident: bib26
  article-title: Central insulin administration improves whole-body insulin sensitivity via hypothalamus and parasympathetic outputs in men
  publication-title: Diabetes
  doi: 10.2337/db14-0477
  contributor:
    fullname: Heni
– volume: 11
  start-page: 998
  year: 2008
  ident: bib62
  article-title: Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
  publication-title: Nature Neuroscience
  doi: 10.1038/nn.2167
  contributor:
    fullname: Tong
– volume: 5
  start-page: 566
  year: 2002
  ident: bib45
  article-title: Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
  publication-title: Nature Neuroscience
  doi: 10.1038/nn0602-861
  contributor:
    fullname: Obici
– volume: 26
  year: 2017
  ident: bib19
  article-title: A hypothalamic phosphatase switch coordinates energy expenditure with feeding
  publication-title: Cell Metabolism
  doi: 10.1016/j.cmet.2017.08.001
  contributor:
    fullname: Dodd
– volume: 4
  year: 2015
  ident: bib28
  article-title: Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss
  publication-title: eLife
  doi: 10.7554/eLife.09800
  contributor:
    fullname: Henry
– volume: 11
  start-page: 286
  year: 2010
  ident: bib30
  article-title: Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility
  publication-title: Cell Metabolism
  doi: 10.1016/j.cmet.2010.03.002
  contributor:
    fullname: Hill
– volume: 449
  start-page: 228
  year: 2007
  ident: bib49
  article-title: Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
  publication-title: Nature
  doi: 10.1038/nature06098
  contributor:
    fullname: Parton
– volume: 30
  year: 2018
  ident: bib55
  article-title: Insulin and leptin excite anorexigenic pro-opiomelanocortin neurones via activation of TRPC5 channels
  publication-title: Journal of Neuroendocrinology
  doi: 10.1111/jne.12501
  contributor:
    fullname: Qiu
– volume: 37
  start-page: 649
  year: 2003
  ident: bib15
  article-title: The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
  publication-title: Neuron
  doi: 10.1016/S0896-6273(03)00063-1
  contributor:
    fullname: Cowley
– volume: 556
  start-page: 505
  year: 2018
  ident: bib70
  article-title: Genetic identification of leptin neural circuits in energy and glucose homeostases
  publication-title: Nature
  doi: 10.1038/s41586-018-0049-7
  contributor:
    fullname: Xu
– volume: 156
  start-page: 495
  year: 2014
  ident: bib67
  article-title: Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding
  publication-title: Cell
  doi: 10.1016/j.cell.2014.01.008
  contributor:
    fullname: Vogt
– volume: 280
  start-page: 445
  year: 2013
  ident: bib61
  article-title: PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis
  publication-title: FEBS Journal
  doi: 10.1111/j.1742-4658.2012.08563.x
  contributor:
    fullname: Tiganis
– volume: 117
  start-page: 2325
  year: 2007
  ident: bib13
  article-title: AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
  publication-title: Journal of Clinical Investigation
  doi: 10.1172/JCI31516
  contributor:
    fullname: Claret
– volume: 116
  start-page: 1886
  year: 2006
  ident: bib51
  article-title: Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
  publication-title: Journal of Clinical Investigation
  doi: 10.1172/JCI27123
  contributor:
    fullname: Plum
– volume: 42
  start-page: 983
  year: 2004
  ident: bib5
  article-title: Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
  publication-title: Neuron
  doi: 10.1016/j.neuron.2004.06.004
  contributor:
    fullname: Balthasar
– volume: 155
  start-page: 172
  year: 2013
  ident: bib56
  article-title: Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance
  publication-title: Cell
  doi: 10.1016/j.cell.2013.09.003
  contributor:
    fullname: Schneeberger
– volume: 28
  start-page: 147
  year: 2000
  ident: bib44
  article-title: Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision
  publication-title: Genesis
  doi: 10.1002/1526-968X(200011/12)28:3/4<147::AID-GENE90>3.0.CO;2-G
  contributor:
    fullname: Novak
– volume: 14
  start-page: 2362
  year: 2016
  ident: bib35
  article-title: Central insulin action activates kupffer cells by suppressing hepatic vagal activation via the nicotinic alpha 7 acetylcholine receptor
  publication-title: Cell Reports
  doi: 10.1016/j.celrep.2016.02.032
  contributor:
    fullname: Kimura
– volume: 10
  start-page: 168
  year: 2004
  ident: bib33
  article-title: Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
  publication-title: Nature Medicine
  doi: 10.1038/nm980
  contributor:
    fullname: Inoue
– volume: 121
  start-page: 1424
  year: 2011
  ident: bib37
  article-title: Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
  publication-title: Journal of Clinical Investigation
  doi: 10.1172/JCI46229
  contributor:
    fullname: Krashes
– volume: 104
  start-page: 5163
  year: 2007
  ident: bib3
  article-title: Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
  publication-title: PNAS
  doi: 10.1073/pnas.0700293104
  contributor:
    fullname: Armbruster
– volume: 66
  start-page: 1797
  year: 2017
  ident: bib27
  article-title: Hypothalamic and striatal insulin action suppresses endogenous glucose production and may stimulate glucose uptake during hyperinsulinemia in lean but not in overweight men
  publication-title: Diabetes
  doi: 10.2337/db16-1380
  contributor:
    fullname: Heni
– volume: 272
  start-page: 827
  year: 1978
  ident: bib25
  article-title: Insulin receptors are widely distributed in the central nervous system of the rat
  publication-title: Nature
  doi: 10.1038/272827a0
  contributor:
    fullname: Havrankova
– volume: 107
  start-page: 14875
  year: 2010
  ident: bib32
  article-title: Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
  publication-title: PNAS
  doi: 10.1073/pnas.1004282107
  contributor:
    fullname: Horvath
– volume: 3
  start-page: 757
  year: 2000
  ident: bib58
  article-title: Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
  publication-title: Nature Neuroscience
  doi: 10.1038/77660
  contributor:
    fullname: Spanswick
– volume: 7
  start-page: 493
  year: 2004
  ident: bib64
  article-title: Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
  publication-title: Nature Neuroscience
  doi: 10.1038/nn1226
  contributor:
    fullname: van den Top
– volume: 13
  start-page: 1079
  year: 2012
  ident: bib65
  article-title: Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis
  publication-title: EMBO reports
  doi: 10.1038/embor.2012.174
  contributor:
    fullname: Varela
– volume: 60
  start-page: 443
  year: 2011
  ident: bib31
  article-title: Effects of insulin on brain glucose metabolism in impaired glucose tolerance
  publication-title: Diabetes
  doi: 10.2337/db10-0940
  contributor:
    fullname: Hirvonen
– volume: 8
  start-page: 1356
  year: 2005
  ident: bib60
  article-title: Topographic mapping of VMH --> arcuate nucleus microcircuits and their reorganization by fasting
  publication-title: Nature Neuroscience
  doi: 10.1038/nn1550
  contributor:
    fullname: Sternson
– volume: 14
  start-page: 22
  year: 2011
  ident: bib22
  article-title: Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization
  publication-title: Nature Neuroscience
  doi: 10.1038/nn.2703
  contributor:
    fullname: Ferguson
– volume: 122
  start-page: 1000
  year: 2012
  ident: bib6
  article-title: Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice
  publication-title: Journal of Clinical Investigation
  doi: 10.1172/JCI59816
  contributor:
    fullname: Berglund
– volume: 3
  start-page: 267
  year: 2006
  ident: bib34
  article-title: Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
  publication-title: Cell Metabolism
  doi: 10.1016/j.cmet.2006.02.009
  contributor:
    fullname: Inoue
– volume: 20
  start-page: 484
  year: 2017
  ident: bib10
  article-title: A molecular census of arcuate hypothalamus and median eminence cell types
  publication-title: Nature Neuroscience
  doi: 10.1038/nn.4495
  contributor:
    fullname: Campbell
– volume: 304
  start-page: 110
  year: 2004
  ident: bib50
  article-title: Rapid rewiring of arcuate nucleus feeding circuits by leptin
  publication-title: Science
  doi: 10.1126/science.1089459
  contributor:
    fullname: Pinto
– volume: 36
  start-page: 65
  year: 2013
  ident: bib16
  article-title: Hypothalamic control of energy balance: insights into the role of synaptic plasticity
  publication-title: Trends in Neurosciences
  doi: 10.1016/j.tins.2012.12.005
  contributor:
    fullname: Dietrich
SSID ssj0000748819
Score 2.5315309
Snippet Hypothalamic neurons respond to nutritional cues by altering gene expression and neuronal excitability. The mechanisms that control such adaptive processes...
SourceID doaj
pubmedcentral
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
SubjectTerms Animals
Biochemistry
Brain
cellular signalling
Diabetes therapy
Excitability
Fasting
Feeding
Gene expression
Genes
Glucose
Glucose - metabolism
Human Biology and Medicine
Humans
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - pharmacology
Hypothalamus
Hypothalamus - cytology
Insulin
Insulin - administration & dosage
Insulin - pharmacology
Insulin resistance
Kinases
Male
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Neuronal Plasticity - drug effects
Neuronal Plasticity - genetics
Neurons
Neurons - metabolism
Neuroscience
Nutrient deficiency
Obesity
Phosphatases
Physiological aspects
Plasticity (neural)
POMC neurons
Pro-Opiomelanocortin - genetics
Pro-Opiomelanocortin - metabolism
Proopiomelanocortin
protein tyrosine phosphatase
Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics
Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism
Receptor, Insulin - genetics
Receptor, Insulin - metabolism
Rodents
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELaqnrhUIKAECjKIa2gefiTHUlFtEaVVKVJvlh8TWKnNVk32wL_vjB1WG3HohWvsKPF8Y8830ucZxj76qiuCbCGHIEMupITcShtyX6pOYMAEaenu8Nl3tfgpvl7L661WX6QJS-WBk-EOO-sUhCYoQOYOVrnKBtuWyXVKlbL1otpKpuIZrNExyzZdyNMYMg_h27KDTzW6p5iFoFip_9_zeCsgzcWSW9Hn5Cnbm2gjP0q_-4ztQP-cLU6TkJzfp4byMPCL87NjHmtU0vQ7pMakmh7_8HHFJ1U6n1Tq_BZG9ICb5XD7gl2dfLk6XuRTZ4Tcq6Ie85q6fAlXg1e4eCdraswnhNYSMF9yqgle1JUuHNpO4AHWlUCb19bBhwIZyku22696eMW4bgHh8g4HpVCVQxbbtEgDWlcFXQXIEM7JVuYu1b8wmDeQSU00qYkmzdhnsuNmChWtjg8QSjNBaR6DMmMfCAVDZSl60r38suthMKc_Ls2RbBUmlvjZjB1Mk7oV4uFxN_j58F8IzbQbBxOr2Gs6nDL2fjNMb5LCrIfVmuYg98X0sdEZ20-Ib1ZDjZUKjOIZ0zNfmC13PtIvf8da3bHefdO8_h_2ecOeIF2LapWyPWC74_0a3iIlGt276P0PzJELXA
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagXLggEK9AQQZxDc3Dj-RUlYpqiyggKNLerNietCvRZLvJHvj3zDju0giJa-woycx4vhnn8wxj71zRZl7WkIKXPhVSQtrIxqcuV61AwATZ0Nnhsy9q8VN8Wspl3HAbIq3yxicGR-17R3vkB6ESuSYDO1xfp9Q1iv6uxhYad9m9vEAoR3vWS73bY0F4rBDxpmN5GoHzAD6vWnhfopGKGRCFev3_euVbsDSnTN7CoJOH7EEMHvnRpO1H7A50j9nidKKT883UVh4G_u3r2TEPlSpp-hoDZOJOj7_52PPITeeRq86vYEQ7-LUarp6w85OP58eLNPZHSJ3KyjEtqdeXsCU4hYmblSW15xNCawmYNVlVeSfKQmfWKhDoxtocaAk3pXc-wzjlKdvr-g6eM65rQKU5i4NSqMJiLFvVGAzUtvC68JCgUqOszHqqgmEweyCRmiBSE0SasA8kx90UKl0dLvSbCxNXgmkbfB1feQWYikGjbNH4ps4nX5CrLGFvSQuGilN0xH65aLbDYE5_fDdHslaYXuJjE7YfJ7U96sPhmnDz4RsVmrgmB_PXghL2ZjdMdxLPrIN-S3MwAsYkstIJezZpfPc11F4pQyxPmJ7Zwuxz5yPd6jJU7A5V76vqxf9f6yW7j-FYYKPk9T7bGzdbeIUhz2hfB7v-A7YDAoI
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV1Lb9RADLZKkVAvCMQrUFBAXLPkMY_kVJWKaotYQNBKvY0yGaddaZuU3azU_nvsSXbV8LhmZpKM7bE_S9_YAO-rtI6dLDBCJ10kpMSolKWLqkTVggImypLvDs--qumZ-Hwuz3dg04xzEODqn6kd95M6Wy4mN79uD-jAE36daIqGH3Axr3GSkeWJe3A_pZDI3K7ZgPO9S9Zkp0nR38_7c80ePODOObHQySg4-Rr-f3vqO6FqTKO8E5eOH8HDAVCGh70FPIYdbJ7A9KSnmIfLvtU8rsLv32ZHoa9eydOvCTQzn7q7Dbs2HPjq4cBfD6-wI9tYzFdXT-H0-NPp0TQaeiZElYqzLsq4_5ewGVaKkjkrM27ZJ4TWEimTsip3lchSHVurUJBrqxPkY11mrnIxYZdnsNu0Db6AUBdIiqwsDUqhUkv4Ni8IIBQ2dTp1GJCiB1mZ674yhqGMgqVr8AtJ13jpBvCR5bidwuWs_YN2eWGG02Hqkn7H5U4hpWdYKpuWriyS3j8kKg7gHWvBcMGKhhkxF-V6tTInP3-YQ1koSjnpswHsD5PqlvRR0TmpxsMbFZqNmRlf316z2wrg7XaYVzL3rMF2zXMIFVNimesAnvca3-5mYzgB6JEtjLY7Hmnml76Kt6-En-cv__vOV7BH6MyTU5JiH3a75RpfEwLq7Btv3b8BlVAE-Q
  priority: 102
  providerName: Scholars Portal
Title Insulin regulates POMC neuronal plasticity to control glucose metabolism
URI https://www.ncbi.nlm.nih.gov/pubmed/30230471
https://www.proquest.com/docview/2127572578
https://search.proquest.com/docview/2116128787
https://pubmed.ncbi.nlm.nih.gov/PMC6170188
https://doaj.org/article/fab6ed8d6e114ea6b2ada91531963160
Volume 7
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07b9swECaSdOlStOhLbWqoRVfZevAhjYmRwCnq1EhTwBshkqfUQCwZljzk3-dI0YaFbl00iCRE3vuEj3eEfNdpFRtWQASGmYgyBlHJShPphFcUHSaw0t4dnt_y2R_6Y8mWJ4Tt78I40L5Wq3H9uB7Xq78OW7lZ68keJzZZzKeuiDhmbqfkFN3vUYruzK9AmUyK_i6eQG85gZ-rCsYZSqbtwmO75MRUJANH5Or1_2uVj9zSEDJ55IOuX5NXPngML_pNviEnUL8ls5seTh5u-7by0IaLX_Np6CpV2ukbDJAtdrp7Crsm9Nj00GPVwzV0KAePq3b9jtxfX91PZ5HvjxBpHmddlNleX1RloDkmbopltj0fpUIwwKxJ8dxomqUiVooDRTNWJWBVuMyMNjHGKe_JWd3U8JGEogBkmlY4yChPFcayeYHBQKFSI1IDATLV00pu-ioYErMHS13pqCsddQNyael4mGJLV7sXzfZBegbKqsTtmNxwwFQMSq7S0pRF0tuChMcB-Wa5IG1xitqiXx7KXdvKm9938oIVHNNL_GxAzv2kqkF-aNQJPRzes1B6nWylq2UvrIkKyNfDsF1pcWY1NDs7ByNgTCJzEZAPPccPp9kLTkDEQBYGxx2OoAC7it1eYD_998rP5CVGag6okhTn5Kzb7uALRkOdGqEOLMWIvLi8ul3cjdw_BXzOaT5yevEMYiUPug
link.rule.ids 230,314,727,780,784,864,885,2102,12056,21388,24318,27924,27925,31719,31720,33744,33745,43310,43805,53791,53793,73745,74302
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELege4AXNMRX2ICAeA1LE9tJntA2bWqhLdMo0t6s2L5slVhSmvSB_547xyuLkHiNHSW5O9-H8_PvGPtokiq2ooAIrLARFwKiUpQ2MmNZcQyYIEo6OzxfyMkP_uVKXPkNt9bDKu98onPUtjG0R37kmMgzMrDP618RdY2iv6u-hcZDtkfM6WLE9k7OFheXu10WDJA5xrz-YF6GofMIZqsKPqVopnwQihxj_79--V5gGoIm70Wh8332xKeP4XGv76fsAdTP2GTaA8rDTd9YHtrw4tv8NHRclTR9jSkyoae732HXhB6dHnq0engLHVrCz1V7-5wtz8-Wp5PId0iIjIzTLkqp2xfXKRiJpZsWKTXo4zzLBGDdpGVuDU-TLNZaAkdHVo2BFnGZWmNjzFResFHd1PCKhVkBqDajcVBwmWjMZvMC04FCJzZLLASoVi8rte55MBTWDyRS5USqnEgDdkJy3E0h8mp3odlcK78WVFXi69jcSsBiDEqpk9KWxbj3BmMZB-wDaUERPUVN-Jfrctu2avr9Uh2LQmKBiY8N2KGfVDWoD4OrwgyH71So_Kps1V8bCtj73TDdSUizGpotzcEcGMvIPAvYy17ju6-hBksxRvOAZQNbGHzucKRe3TjObsd7n-ev__9a79ijyXI-U7Pp4usBe4zJmcOmjItDNuo2W3iDCVCn33or_wNmMAbY
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fb9MwELagkxAvCMSvsAEB8RqaJraTPKFtrGphK9UY0t6s2L6MSizpmvSB_547xyuLkHiNHcW-O993l3y5Y-yDSarYigIisMJGXAiISlHayExkxREwQZT07_DZQs5-8C-X4tLzn1pPq7z1ic5R28bQO_Kxq0SekYGNK0-LWH6eflrfRNRBir60-nYa99keomKcjNje0clieb5744JgmSP-9T_pZQijYzhdVfAxRZPlA1hy1fv_9dF3QGpIoLyDSNPH7JEPJcPDXvdP2D2on7LZvCeXh5u-yTy04fLb2XHo6lbS9DWGy8Sk7n6HXRN6pnromevhNXRoFb9W7fUzdjE9uTieRb5bQmRknHZRSp2_uE7BSEzjtEipWR_nWSYAcygtc2t4mmSx1hI4OrVqAnSgy9QaG2PU8pyN6qaGlyzMCkAVGo2DgstEY2SbFxgaFDqxWWIhQBV7Wal1XxNDYS5BIlVOpMqJNGBHJMfdFCpk7S40myvlz4WqSlyOza0ETMyglDopbVlMes8wkXHA3pMWFJWqqEnpV-W2bdX8-7k6FIXEZBMfG7ADP6lqUB8GT4gZDt-qUPkT2qq_9hSwd7thupNYZzU0W5qD8TCmlHkWsBe9xne7oWZLMSJ7wLKBLQy2OxypVz9d_W5XAz_PX_1_WW_ZAzRwdTpffN1nDzFOczSVSXHARt1mC68xFur0G2_kfwCMGgsF
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Insulin+regulates+POMC+neuronal+plasticity+to+control+glucose+metabolism&rft.jtitle=eLife&rft.au=Dodd%2C+Garron+T&rft.au=Michael%2C+Natalie+J&rft.au=Lee-Young%2C+Robert+S&rft.au=Mangiafico%2C+Salvatore+P&rft.date=2018-09-19&rft.eissn=2050-084X&rft.volume=7&rft_id=info:doi/10.7554%2Felife.38704&rft_id=info%3Apmid%2F30230471&rft.externalDocID=30230471
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2050-084X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2050-084X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2050-084X&client=summon