P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium calpain-dependent mechanism

• Published in: Oncogene Vol. 30; no. 41; pp. 4219 - 4230
• Main Authors: Al-Bahlani, S, Fraser, M, Wong, A Y C, Sayan, B S, Bergeron, R, Melino, G, Tsang, B K
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.10.2011; Nature Publishing Group
• Subjects: 631/80/82/23; 631/80/86; 692/699/67/1059/2326; 692/699/67/1517/1709; Ageing, cell death; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; Biological and medical sciences; Blotting, Western; Ca super(2+)-transporting ATPase; Calcium; Calcium (extracellular); Calcium (intracellular); Calcium - metabolism; Calpain; Calpain - antagonists & inhibitors; Calpain - genetics; Calpain - metabolism; Care and treatment; Cell Biology; Cell cycle; Cell Line, Tumor; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Chemoresistance; Cisplatin; Cisplatin - pharmacology; cyclopiazonic acid; Cysteine Proteinase Inhibitors - pharmacology; Dipeptides - pharmacology; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Drug Resistance, Neoplasm; Female; Female genital diseases; Fundamental and applied biological sciences. Psychology; Gene expression; Genetic aspects; Gynecology. Andrology. Obstetrics; Health aspects; Human Genetics; Humans; Immunoprecipitation; Internal Medicine; Intracellular Space - drug effects; Intracellular Space - metabolism; Medical sciences; Medicine; Medicine & Public Health; Molecular and cellular biology; Molecular modelling; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Oncology; Original; original-article; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Overexpression; Poly(ADP-ribose) polymerase; Protein Binding - drug effects; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal transduction; Tumor Protein p73; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Tumors; Canada; calpain; CDDP; calcium; ovarian cancer; p73α; Antineoplastic agent; Calcium; Enzyme; Cysteine endopeptidases; Ovary cancer; Calpain; Malignant tumor; Carcinogenesis; Cisplatin; Mechanism; Female genital diseases; Ovarian diseases; Peptidases; Regulation(control); Hydrolases; Cancer; Apoptosis

P73 is important in drug-induced apoptosis in some cancer cells, yet its role in the regulation of chemosensitivity in ovarian cancer (OVCA) is poorly understood. Furthermore, if and how the deregulation of p73-mediated apoptosis confers resistance to cisplatin (CDDP) treatment is unclear. Here we d...