Total adiponectin in overweight and obese subjects and its response to visceral fat loss

• Published in: BMC endocrine disorders Vol. 19; no. 1; pp. 55 - 6
• Main Authors: Gariballa, Salah, Alkaabi, Juma, Yasin, Javed, Al Essa, Awad
• Format: Journal Article
• Language: English
• Published: London BioMed Central 03.06.2019; BioMed Central Ltd; BMC
• Subjects: Adiponectin; Adiponectin - blood; Adipose tissue; Adolescent; Adult; Analysis; Asian people; Basic and Clinical Endocrinology; Biomarkers - blood; Body Composition; Body Mass Index; Body weight; Cardiovascular disease; Care and treatment; Chronic illnesses; Community health services; Composition; Cytokines; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diagnosis; Diet; Education; Endocrinology; Fasting; Female; Follow-Up Studies; Gastrointestinal surgery; Gender; Health aspects; Hip; Hormones; Humans; Incidence; Inflammation; Insulin resistance; Intervention; Intra-Abdominal Fat - physiopathology; Longitudinal Studies; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Molecular weight; Morbidity; Multiple regression analysis; Multivariate analysis; Nutritional status; Obesity; Obesity - blood; Obesity - diagnosis; Obesity - epidemiology; Overweight; Overweight - blood; Overweight - diagnosis; Overweight - epidemiology; Population; Prognosis; Prospective Studies; Regression analysis; Research Article; Retirement benefits; rology; Statistics; Studies; Systematic review; Type 2 diabetes; United Arab Emirates - epidemiology; Visceral fat; Waist Circumference; Weight control; Young Adult; United Arab Emirates; Visceral fat; Obesity; Diet; Adiponectin
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-019-0386-z

Background Visceral obesity and related diabetes is reaching epidemic proportions in the United Arab Emirates (UAE). Adiponectin is a hormone that is secreted by adipose tissue and may play an important role in obesity-related morbidity. The aim of this study was to investigate total adiponectin levels in overweight and obese UAE subjects visiting health care facilities for weight management. Methods All overweight and obese subjects visiting community health centers were invited to take part in the study. Two hundred and six participants received individualized structured dietary education for weight management. Demographic data, anthropometric measurements and fasting venous blood samples were taken for measurements of total adiponectin and markers of inflammation and nutritional status at baseline and follow up. Multivariate analysis was performed to determine the independent effects of prognostic factors on serum adiponectin levels. Results A total of 193 (93%) females with a mean age (±SD) 36 ± 11 years were included in the analysis. During a follow up period of 427 ± 223 days, participants received 13 ± 5 structured dietary education sessions. We observed decreased levels of total adiponectin with increasing quartiles of both waist circumference (WC) and body mass index (BMI). Male gender and history of both gestational and type 2 diabetes were associated with significantly lower total adiponectin levels ( p  < 0.05). After adjusting for age, gender, BMI and hip circumference, multiple regression analysis revealed a significant and independent association between waist circumference and total adiponectin levels. At follow up visceral fat loss was associated with a significant decrease in inflammatory markers and a non-significant increase in total adiponectin levels. Conclusion Increased visceral fat in overweight and obese subjects is associated with decreased total adiponectin levels. The health benefits of increasing adiponectin levels using different dietary intervention strategies need to be explored in larger studies. Trial registration NCT01691365 , registered on 11/09/2012.