Non-apoptotic functions of apoptosis-regulatory proteins

During the past two decades, apoptotic cell death has been the subject of an intense wave of investigation, leading to the discovery of multiple gene products that govern both its induction and execution. In parallel, it has progressively become evident that most, if not all, proteins that had initi...

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Published inEMBO reports Vol. 13; no. 4; pp. 322 - 330
Main Authors Galluzzi, Lorenzo, Kepp, Oliver, Trojel-Hansen, Christina, Kroemer, Guido
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.04.2012
Nature Publishing Group UK
Springer Nature B.V
Nature Publishing Group
Subjects
AIF
Animals
Apoptosis
Apoptosis Regulatory Proteins - metabolism
apoptosome
Autophagy
BCL-2
Biochemistry
caspase
Cell Cycle
Cell Differentiation
death receptor
EMBO07
EMBO37
Humans
Mitochondria
mitochondrial membrane permeabilization
Models, Biological
Mortality
Physiology
Proteins
Review
BCL‐2
apoptosome
AIF
caspase
death receptor
mitochondrial membrane permeabilization
Online AccessGet full text
ISSN1469-221X
1469-3178
1469-3178
DOI10.1038/embor.2012.19

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Abstract During the past two decades, apoptotic cell death has been the subject of an intense wave of investigation, leading to the discovery of multiple gene products that govern both its induction and execution. In parallel, it has progressively become evident that most, if not all, proteins that had initially been discovered for their essential role in apoptosis also mediate a wide range of non‐apoptotic functions. On the one hand, apoptotic regulators and executioners are involved in non‐lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation. On the other hand, pro‐apoptotic proteins can control other modalities of programmed cell death, in particular regulated necrosis. In this review, we summarize the unconventional roles of the apoptotic core machinery from a functional perspective and discuss their pathophysiological implications. EMBO reports advance online publication 9 March 2012; doi:10.1038/embor.2012.19 Galluzzi, Kroemer and colleagues summarize the important roles of apoptotic regulators and executioners in non‐lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation.
AbstractList During the past two decades, apoptotic cell death has been the subject of an intense wave of investigation, leading to the discovery of multiple gene products that govern both its induction and execution. In parallel, it has progressively become evident that most, if not all, proteins that had initially been discovered for their essential role in apoptosis also mediate a wide range of non-apoptotic functions. On the one hand, apoptotic regulators and executioners are involved in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation. On the other hand, pro-apoptotic proteins can control other modalities of programmed cell death, in particular regulated necrosis. In this review, we summarize the unconventional roles of the apoptotic core machinery from a functional perspective and discuss their pathophysiological implications.During the past two decades, apoptotic cell death has been the subject of an intense wave of investigation, leading to the discovery of multiple gene products that govern both its induction and execution. In parallel, it has progressively become evident that most, if not all, proteins that had initially been discovered for their essential role in apoptosis also mediate a wide range of non-apoptotic functions. On the one hand, apoptotic regulators and executioners are involved in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation. On the other hand, pro-apoptotic proteins can control other modalities of programmed cell death, in particular regulated necrosis. In this review, we summarize the unconventional roles of the apoptotic core machinery from a functional perspective and discuss their pathophysiological implications.
During the past two decades, apoptotic cell death has been the subject of an intense wave of investigation, leading to the discovery of multiple gene products that govern both its induction and execution. In parallel, it has progressively become evident that most, if not all, proteins that had initially been discovered for their essential role in apoptosis also mediate a wide range of non‐apoptotic functions. On the one hand, apoptotic regulators and executioners are involved in non‐lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation. On the other hand, pro‐apoptotic proteins can control other modalities of programmed cell death, in particular regulated necrosis. In this review, we summarize the unconventional roles of the apoptotic core machinery from a functional perspective and discuss their pathophysiological implications. EMBO reports advance online publication 9 March 2012; doi:10.1038/embor.2012.19 Galluzzi, Kroemer and colleagues summarize the important roles of apoptotic regulators and executioners in non‐lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation.
During the past two decades, apoptotic cell death has been the subject of an intense wave of investigation, leading to the discovery of multiple gene products that govern both its induction and execution. In parallel, it has progressively become evident that most, if not all, proteins that had initially been discovered for their essential role in apoptosis also mediate a wide range of non-apoptotic functions. On the one hand, apoptotic regulators and executioners are involved in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation. On the other hand, pro-apoptotic proteins can control other modalities of programmed cell death, in particular regulated necrosis. In this review, we summarize the unconventional roles of the apoptotic core machinery from a functional perspective and discuss their pathophysiological implications.
Galluzzi, Kroemer and colleagues summarize the important roles of apoptotic regulators and executioners in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation. During the past two decades, apoptotic cell death has been the subject of an intense wave of investigation, leading to the discovery of multiple gene products that govern both its induction and execution. In parallel, it has progressively become evident that most, if not all, proteins that had initially been discovered for their essential role in apoptosis also mediate a wide range of non-apoptotic functions. On the one hand, apoptotic regulators and executioners are involved in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation. On the other hand, pro-apoptotic proteins can control other modalities of programmed cell death, in particular regulated necrosis. In this review, we summarize the unconventional roles of the apoptotic core machinery from a functional perspective and discuss their pathophysiological implications. EMBO reports advance online publication 9 March 2012; doi:10.1038/embor.2012.19
During the past two decades, apoptotic cell death has been the subject of an intense wave of investigation, leading to the discovery of multiple gene products that govern both its induction and execution. In parallel, it has progressively become evident that most, if not all, proteins that had initially been discovered for their essential role in apoptosis also mediate a wide range of non‐apoptotic functions. On the one hand, apoptotic regulators and executioners are involved in non‐lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation. On the other hand, pro‐apoptotic proteins can control other modalities of programmed cell death, in particular regulated necrosis. In this review, we summarize the unconventional roles of the apoptotic core machinery from a functional perspective and discuss their pathophysiological implications.EMBO reports advance online publication 9 March 2012; doi:10.1038/embor.2012.19 Galluzzi, Kroemer and colleagues summarize the important roles of apoptotic regulators and executioners in non‐lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation.
During the past two decades, apoptotic cell death has been the subject of an intense wave of investigation, leading to the discovery of multiple gene products that govern both its induction and execution. In parallel, it has progressively become evident that most, if not all, proteins that had initially been discovered for their essential role in apoptosis also mediate a wide range of non-apoptotic functions. On the one hand, apoptotic regulators and executioners are involved in non-lethal physiological processes as diverse as cell cycle progression, differentiation, metabolism, autophagy and inflammation. On the other hand, pro-apoptotic proteins can control other modalities of programmed cell death, in particular regulated necrosis. In this review, we summarize the unconventional roles of the apoptotic core machinery from a functional perspective and discuss their pathophysiological implications. [PUBLICATION ABSTRACT]
Author Kepp, Oliver
Trojel‐Hansen, Christina
Galluzzi, Lorenzo
Kroemer, Guido
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Issue 4
Keywords BCL‐2
apoptosome
AIF
caspase
death receptor
mitochondrial membrane permeabilization
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Snippet During the past two decades, apoptotic cell death has been the subject of an intense wave of investigation, leading to the discovery of multiple gene products...
Galluzzi, Kroemer and colleagues summarize the important roles of apoptotic regulators and executioners in non-lethal physiological processes as diverse as...
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SubjectTerms AIF
Animals
Apoptosis
Apoptosis Regulatory Proteins - metabolism
apoptosome
Autophagy
BCL-2
Biochemistry
caspase
Cell Cycle
Cell Differentiation
death receptor
EMBO07
EMBO37
Humans
Mitochondria
mitochondrial membrane permeabilization
Models, Biological
Mortality
Physiology
Proteins
Review
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Title Non-apoptotic functions of apoptosis-regulatory proteins
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https://link.springer.com/article/10.1038/embor.2012.19
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Volume 13
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