Tumor Microenvironment‐Driven Structural Transformation of Vanadium‐Based MXenzymes to Amplify Oxidative Stress for Multimodal Tumor Therapy

• Published in: Advanced science Vol. 12; no. 11; pp. e2408998 - n/a
• Main Authors: Zhu, Hai, Li, Tinghua, Peng, Xinhao, Zhang, Xiaoxian, Zhang, Xuequan, Wang, Qiusheng, Lei, Lei, Zhang, Jun, He, Bin, Cao, Jun
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.03.2025; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Apoptosis; catalytic therapy; Cell Line, Tumor; Combined Modality Therapy - methods; Efficiency; Enzymes; ferroptosis; Humans; Metabolism; Mice; Microscopy; Morphology; MXenzymes; Nanomaterials; Nanoparticles; Neoplasms - metabolism; Neoplasms - therapy; NIR‐II PTT; Oxidation; Oxidative stress; Oxidative Stress - drug effects; Particle size; Spectrum analysis; Tumor Microenvironment - drug effects; Tumors; Vanadium - chemistry; Vanadium - pharmacology; Vanadium Compounds - pharmacology; catalytic therapy; ferroptosis; oxidative stress; MXenzymes; NIR‐II PTT

MXenzymes, a promising class of catalytic therapeutic material, offer great potential for tumor treatment, but they encounter significant obstacles due to suboptimal catalytic efficiency and kinetics in the tumor microenvironment (TME). Herein, this study draws inspiration from the electronic struct...