SARS‐CoV‐2 infection as a trigger of autoimmune response

• Published in: Clinical and translational science Vol. 14; no. 3; pp. 898 - 907
• Main Authors: Sacchi, Maria C., Tamiazzo, Stefania, Stobbione, Paolo, Agatea, Lisa, De Gaspari, Piera, Stecca, Anna, Lauritano, Ernesto C., Roveta, Annalisa, Tozzoli, Renato, Guaschino, Roberto, Bonometti, Ramona
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.05.2021; John Wiley and Sons Inc; Wiley
• Subjects: Adult; Age; Aged; Aged, 80 and over; Antibodies; Antigens; Antineutrophil cytoplasmic antibodies; Antinuclear antibodies; Autoantibodies; Autoantibodies - blood; Autoimmune diseases; Autoimmune Diseases - etiology; Autoimmunity; Blood & organ donations; Blood donors; C-reactive protein; Coronaviruses; COVID-19; COVID-19 - diagnostic imaging; COVID-19 - immunology; Creatinine; Cytokines; Demographics; Disease; Dyspnea; Female; Ferritin; Fever; Glycoproteins; Humans; Immune system; Immunoassay; Immunoglobulin A; Infections; Inflammation; Inflammation - etiology; L-Lactate dehydrogenase; Laboratories; Lactic acid; Lymphocytes; Male; Middle Aged; Normal distribution; Pathogens; Patients; Proteins; Public health; SARS-CoV-2; Scleroderma; Severe acute respiratory syndrome coronavirus 2; Tumor necrosis factor-TNF; Values; Viral diseases; Viruses; Italy

Currently, few evidences have shown the possible involvement of autoimmunity in patients affected by coronavirus disease 2019 (COVID‐19). In this study, we elucidate whether severe acute respiratory syndrome coronavirus disease 2 (SARS‐CoV‐2) stimulates autoantibody production and contributes to aut...