甲氰咪胍影响非酒精性脂肪性肝炎大鼠血糖、胰岛素等指标的实验研究
R575.5; 探讨非酒精性脂肪性肝炎(NASH)大鼠经甲氰咪胍治疗后肝微粒体CYP450、CYP2E1含量、血糖、胰岛素等指标的变化.将30只雄性SD大鼠随机分为对照组(n=10)、模型组(n=10)和治疗组(n=10),治疗组给予甲氰咪胍200 mg·kg-1·d-1灌胃,饲养12周,分别于实验第4、6、8、10、12周采用剪尾取血法取血,前四次取血测定血糖、AST、ALT含量,最后一次处死大鼠后取血测定血糖、胰岛素、肝功、血脂、CYP450及CYP2E1含量,观察肝组织学特点.观察到模型组大鼠肝功、血糖指标升高,并随实验进展更加明显;治疗组CYP450、CYP2E1、ALT、AST含量均...
Saved in:
| Published in | 临床肝胆病杂志 Vol. 23; no. 2; pp. 112 - 114 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
第四军医大学唐都医院,消化科,陕西,西安,710038%第四军医大学唐都医院,传染科,陕西,西安,710038%第四军医大学唐都医院,检验科,陕西,西安,710038
2007
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 |
| DOI | 10.3969/j.issn.1001-5256.2007.02.013 |
Cover
| Abstract | R575.5; 探讨非酒精性脂肪性肝炎(NASH)大鼠经甲氰咪胍治疗后肝微粒体CYP450、CYP2E1含量、血糖、胰岛素等指标的变化.将30只雄性SD大鼠随机分为对照组(n=10)、模型组(n=10)和治疗组(n=10),治疗组给予甲氰咪胍200 mg·kg-1·d-1灌胃,饲养12周,分别于实验第4、6、8、10、12周采用剪尾取血法取血,前四次取血测定血糖、AST、ALT含量,最后一次处死大鼠后取血测定血糖、胰岛素、肝功、血脂、CYP450及CYP2E1含量,观察肝组织学特点.观察到模型组大鼠肝功、血糖指标升高,并随实验进展更加明显;治疗组CYP450、CYP2E1、ALT、AST含量均低于模型组(P＜0.05),且大鼠的肝细胞损害明显减轻,但其余指标无显著差异.可见甲氰咪胍能够减轻NASH大鼠肝细胞损害,抑制CYP450、CYP2E1表达,改善肝功水平,不能改善胰岛素抵抗,及降低血糖、血脂. |
|---|---|
| AbstractList | R575.5; 探讨非酒精性脂肪性肝炎(NASH)大鼠经甲氰咪胍治疗后肝微粒体CYP450、CYP2E1含量、血糖、胰岛素等指标的变化.将30只雄性SD大鼠随机分为对照组(n=10)、模型组(n=10)和治疗组(n=10),治疗组给予甲氰咪胍200 mg·kg-1·d-1灌胃,饲养12周,分别于实验第4、6、8、10、12周采用剪尾取血法取血,前四次取血测定血糖、AST、ALT含量,最后一次处死大鼠后取血测定血糖、胰岛素、肝功、血脂、CYP450及CYP2E1含量,观察肝组织学特点.观察到模型组大鼠肝功、血糖指标升高,并随实验进展更加明显;治疗组CYP450、CYP2E1、ALT、AST含量均低于模型组(P＜0.05),且大鼠的肝细胞损害明显减轻,但其余指标无显著差异.可见甲氰咪胍能够减轻NASH大鼠肝细胞损害,抑制CYP450、CYP2E1表达,改善肝功水平,不能改善胰岛素抵抗,及降低血糖、血脂. |
| Author | 李军 王旭霞 闻勤生 张亚飞 顾柄权 徐辉 |
| AuthorAffiliation | 第四军医大学唐都医院,消化科,陕西,西安,710038%第四军医大学唐都医院,传染科,陕西,西安,710038%第四军医大学唐都医院,检验科,陕西,西安,710038 |
| AuthorAffiliation_xml | – name: 第四军医大学唐都医院,消化科,陕西,西安,710038%第四军医大学唐都医院,传染科,陕西,西安,710038%第四军医大学唐都医院,检验科,陕西,西安,710038 |
| Author_xml | – sequence: 1 fullname: 徐辉 – sequence: 2 fullname: 闻勤生 – sequence: 3 fullname: 王旭霞 – sequence: 4 fullname: 张亚飞 – sequence: 5 fullname: 李军 – sequence: 6 fullname: 顾柄权 |
| BookMark | eNo9UE1LAlEAfAeDzPwXHbrs9j52n-8dQ_oCoYvXkN11nyiyQksEnmw1JFAPJh0KZYNAEorNolP1Z2L37f6LVooOwwwzMAOzATJOy7EB2EJQJZzynYZad11HRRAiRcc6VTGEBRViFSKSAdl_fx3kXbduQh0RyjWdZsGJnCyjIAjHi7g7DD9fwuthMp0ll2O5_Io687jnxd5iJbyp9Ebhwzz58OP7jny9-e5cxN0gXN7JN18-XUWDfuT35W0vfJ4li4H0J_LxfROsCaPp2vk_zoHy_l65eKiUjg-OirslxaKQKKbgTFQFNoRJUmiEQI5sZAnIC4jqdhpyixIbU4GYgRhjpsGqhNkYI6xpjOTA9m_tueEIw6lVGq2zUycdrDStWtVst1d3QJyeQX4AB2F6eg |
| ClassificationCodes | R575.5 |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3969/j.issn.1001-5256.2007.02.013 |
| DatabaseName | Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitle_FL | The effect of cimetidine on the blood sugar, serum insulin and other indexes in NASH rats |
| EndPage | 114 |
| ExternalDocumentID | lcgdbzz200702013 |
| GrantInformation_xml | – fundername: 陕西省自然科学基金 funderid: (2003C2035) |
| GroupedDBID | -05 2B. 4A8 5XA 5XF 92F 92I 93N ABDBF ABJNI ACGFS ACUHS ALMA_UNASSIGNED_HOLDINGS CCEZO CIEJG CW9 EAD EAP EOJEC ESX IPNFZ OBODZ OK1 PSX RIG RNS TCJ TGQ U1G U5O |
| ID | FETCH-LOGICAL-c603-bf98fdf2afb3afb433091e1cf097165e8fd9c63e26f18a1888ba8d38e22124483 |
| ISSN | 1001-5256 |
| IngestDate | Thu May 29 03:59:48 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | 非酒精性脂肪性肝炎 血脂 细胞色素P450 肝功 甲氰咪胍 胰岛素抵抗 |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c603-bf98fdf2afb3afb433091e1cf097165e8fd9c63e26f18a1888ba8d38e22124483 |
| PageCount | 3 |
| ParticipantIDs | wanfang_journals_lcgdbzz200702013 |
| PublicationCentury | 2000 |
| PublicationDate | 2007 |
| PublicationDateYYYYMMDD | 2007-01-01 |
| PublicationDate_xml | – year: 2007 text: 2007 |
| PublicationDecade | 2000 |
| PublicationTitle | 临床肝胆病杂志 |
| PublicationTitle_FL | CHINESE JOURNAL OF CLINICAL HEPATOLOGY |
| PublicationYear | 2007 |
| Publisher | 第四军医大学唐都医院,消化科,陕西,西安,710038%第四军医大学唐都医院,传染科,陕西,西安,710038%第四军医大学唐都医院,检验科,陕西,西安,710038 |
| Publisher_xml | – name: 第四军医大学唐都医院,消化科,陕西,西安,710038%第四军医大学唐都医院,传染科,陕西,西安,710038%第四军医大学唐都医院,检验科,陕西,西安,710038 |
| SSID | ssib051369456 ssj0041983 ssib001103858 ssib053243598 ssib002264326 ssib038074677 |
| Score | 1.6890627 |
| Snippet | R575.5; 探讨非酒精性脂肪性肝炎(NASH)大鼠经甲氰咪胍治疗后肝微粒体CYP450、CYP2E1含量、血糖、胰岛素等指标的变化.将30只雄性SD大鼠随机分为对照组(n=10)、模型组(n=10)和治疗组(n=10),治疗组给予甲氰咪胍200... |
| SourceID | wanfang |
| SourceType | Aggregation Database |
| StartPage | 112 |
| Title | 甲氰咪胍影响非酒精性脂肪性肝炎大鼠血糖、胰岛素等指标的实验研究 |
| URI | https://d.wanfangdata.com.cn/periodical/lcgdbzz200702013 |
| Volume | 23 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwzR1Na9RANJQWihfxE7-p0DmmJpNJMnNMslmKUE8VepGSZJN6kBW0vexB6rZShNZDLR6UlhWEYkGpVTypf0Z2s_svfG8yu5uWIlUQhN3l7cyb9zlJ3tvNe9G0yVSAK5OU6Szjqc6SWqTzrJbqIo3g6pEy15aNtGfuONN32e05e25kbKlcXbIYTyWNY-tK_sarMAZ-xSrZP_DsgCgMAAz-hU_wMHyeyMckdIlgxKckdIhv4Cu0iaDE80jICbcIr-CIXyG-KaeKEUFEhYgQAS7xgQ4Q8UOkww3iuXI5hJlUAgXB8hRFCrAKAB4iZY_JKUH8gHgG4ngm4iNliwiHhBZ-5aYSrBAVmApf4jC5yiVehXAheQWEuwjAOAKgqYciIa9QCQ9SARquMtAOCIAATjngJiHYhyN9ZAf4Xkn-wkSOJO6iKYAdjKPWgFwlYnCRlgPAVmoGABfDGYGLfR9RuI-GKLwiqkMUF60Ek0hf6oiLAtDiEP3CcgzFBF1RP6uP0v9dxh0cQ1LbAF_oV1_a0UZlFBAokZRjbOTqORKZST2EdEOlhAwyAU8KR53cT-ADrmaFtBHQEaaclZjClm6WlsLBPlx4CLxIA2zqhJ3x7X8sLesbDwhWcZf_19I66FhuHN7BfyltKajA2xZtWjTQ70cdRZW9OrvSUghhqrKCVH1jxwU6lnCEDHSQwdSAgWrJSqeMosD7SCv5B8lCLW40EAmyRHzW9xh1XRPvhJ55Eg6zKNM41OIKa-1LWR4-ooKVumDapuUINmzJZUOOhn1B-wExMwUv6pyUlOPapFLh1u8UkGWU9SyqL5Qi_tkz2mmVqk94xXn3rDbSuH9OG59RNyOd1-7lWwed_f325l53ZaP9_VP75UZve6f3bDM_-NFZ3u2uNrvNPQSa23nzRfvdbu9bq_t2Of_86ufy0-7KfvvgTf6llX943llf67TW8ter7Y87vb31vLWVv_96QZuthrPBtK6eVqMnjmHpcSbgIpfRKIsteDPLgkwsNZNMNumzU5gUiWOl1MlMHpmc8zjiNYunlGKKxa2L2mj9YT29pE04cWpDmgj4FHIMxxaRGbsiY8JicWwz97J2UxlmXl2MHs8fde2VE-Bc1U4V_1ThD8rXtNHFR0vpdUixFuMbckP8Avj-E9A |
| linkProvider | ISSN International Centre |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E7%94%B2%E6%B0%B0%E5%92%AA%E8%83%8D%E5%BD%B1%E5%93%8D%E9%9D%9E%E9%85%92%E7%B2%BE%E6%80%A7%E8%84%82%E8%82%AA%E6%80%A7%E8%82%9D%E7%82%8E%E5%A4%A7%E9%BC%A0%E8%A1%80%E7%B3%96%E3%80%81%E8%83%B0%E5%B2%9B%E7%B4%A0%E7%AD%89%E6%8C%87%E6%A0%87%E7%9A%84%E5%AE%9E%E9%AA%8C%E7%A0%94%E7%A9%B6&rft.jtitle=%E4%B8%B4%E5%BA%8A%E8%82%9D%E8%83%86%E7%97%85%E6%9D%82%E5%BF%97&rft.au=%E5%BE%90%E8%BE%89&rft.au=%E9%97%BB%E5%8B%A4%E7%94%9F&rft.au=%E7%8E%8B%E6%97%AD%E9%9C%9E&rft.au=%E5%BC%A0%E4%BA%9A%E9%A3%9E&rft.date=2007&rft.pub=%E7%AC%AC%E5%9B%9B%E5%86%9B%E5%8C%BB%E5%A4%A7%E5%AD%A6%E5%94%90%E9%83%BD%E5%8C%BB%E9%99%A2%2C%E6%B6%88%E5%8C%96%E7%A7%91%2C%E9%99%95%E8%A5%BF%2C%E8%A5%BF%E5%AE%89%2C710038%25%E7%AC%AC%E5%9B%9B%E5%86%9B%E5%8C%BB%E5%A4%A7%E5%AD%A6%E5%94%90%E9%83%BD%E5%8C%BB%E9%99%A2%2C%E4%BC%A0%E6%9F%93%E7%A7%91%2C%E9%99%95%E8%A5%BF%2C%E8%A5%BF%E5%AE%89%2C710038%25%E7%AC%AC%E5%9B%9B%E5%86%9B%E5%8C%BB%E5%A4%A7%E5%AD%A6%E5%94%90%E9%83%BD%E5%8C%BB%E9%99%A2%2C%E6%A3%80%E9%AA%8C%E7%A7%91%2C%E9%99%95%E8%A5%BF%2C%E8%A5%BF%E5%AE%89%2C710038&rft.issn=1001-5256&rft.volume=23&rft.issue=2&rft.spage=112&rft.epage=114&rft_id=info:doi/10.3969%2Fj.issn.1001-5256.2007.02.013&rft.externalDocID=lcgdbzz200702013 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Flcgdbzz%2Flcgdbzz.jpg |