Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects
Major depressive disorder (MDD) has been linked to changes in function and activity of the hippocampus, one of the central limbic regions involved in regulation of emotions and mood. The exact cellular and molecular mechanisms underlying hippocampal plasticity in response to stress are yet to be ful...
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| Published in | The international journal of neuropsychopharmacology Vol. 16; no. 1; pp. 69 - 82 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge, UK
Cambridge University Press
01.02.2013
Oxford University Press |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Major depressive disorder (MDD) has been linked to changes in function and activity of the hippocampus, one of the central limbic regions involved in regulation of emotions and mood. The exact cellular and molecular mechanisms underlying hippocampal plasticity in response to stress are yet to be fully characterized. In this study, we examined the genetic profile of micro-dissected subfields of post-mortem hippocampus from subjects diagnosed with MDD and comparison subjects matched for sex, race and age. Gene expression profiles of the dentate gyrus and CA1 were assessed by 48K human HEEBO whole genome microarrays and a subgroup of identified genes was confirmed by real-time polymerase chain reaction (qPCR). Pathway analysis revealed altered expression of several gene families, including cytoskeletal proteins involved in rearrangement of neuronal processes. Based on this and evidence of hippocampal neuronal atrophy in MDD, we focused on the expression of cytoskeletal, synaptic and glutamate receptor genes. Our findings demonstrate significant dysregulation of synaptic function/structure related genes SNAP25, DLG2 (SAP93), and MAP1A, and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and GLUR3. Several of these human target genes were similarly dysregulated in a rat model of chronic unpredictable stress and the effects reversed by antidepressant treatment. Together, these studies provide new evidence that disruption of synaptic and glutamatergic signalling pathways contribute to the pathophysiology underlying MDD and provide interesting targets for novel therapeutic interventions. |
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| AbstractList | Major depressive disorder (MDD) has been linked to changes in function and activity of the hippocampus, one of the central limbic regions involved in regulation of emotions and mood. The exact cellular and molecular mechanisms underlying hippocampal plasticity in response to stress are yet to be fully characterized. In this study, we examined the genetic profile of micro-dissected subfields of post-mortem hippocampus from subjects diagnosed with MDD and comparison subjects matched for sex, race and age. Gene expression profiles of the dentate gyrus and CA1 were assessed by 48K human HEEBO whole genome microarrays and a subgroup of identified genes was confirmed by real-time polymerase chain reaction (qPCR). Pathway analysis revealed altered expression of several gene families, including cytoskeletal proteins involved in rearrangement of neuronal processes. Based on this and evidence of hippocampal neuronal atrophy in MDD, we focused on the expression of cytoskeletal, synaptic and glutamate receptor genes. Our findings demonstrate significant dysregulation of synaptic function/structure related genes SNAP25, DLG2 (SAP93), and MAP1A, and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and GLUR3. Several of these human target genes were similarly dysregulated in a rat model of chronic unpredictable stress and the effects reversed by antidepressant treatment. Together, these studies provide new evidence that disruption of synaptic and glutamatergic signalling pathways contribute to the pathophysiology underlying MDD and provide interesting targets for novel therapeutic interventions. Major depressive disorder (MDD) has been linked to changes in function and activity of the hippocampus, one of the central limbic regions involved in regulation of emotions and mood. The exact cellular and molecular mechanisms underlying hippocampal plasticity in response to stress are yet to be fully characterized. In this study, we examined the genetic profile of micro-dissected subfields of post-mortem hippocampus from subjects diagnosed with MDD and comparison subjects matched for sex, race and age. Gene expression profiles of the dentate gyrus and CA1 were assessed by 48K human HEEBO whole genome microarrays and a subgroup of identified genes was confirmed by real-time polymerase chain reaction (qPCR). Pathway analysis revealed altered expression of several gene families, including cytoskeletal proteins involved in rearrangement of neuronal processes. Based on this and evidence of hippocampal neuronal atrophy in MDD, we focused on the expression of cytoskeletal, synaptic and glutamate receptor genes. Our findings demonstrate significant dysregulation of synaptic function/structure related genes SNAP25 , DLG2 ( SAP93 ), and MAP1A , and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and GLUR3 . Several of these human target genes were similarly dysregulated in a rat model of chronic unpredictable stress and the effects reversed by antidepressant treatment. Together, these studies provide new evidence that disruption of synaptic and glutamatergic signalling pathways contribute to the pathophysiology underlying MDD and provide interesting targets for novel therapeutic interventions. Abstract Major depressive disorder (MDD) has been linked to changes in function and activity of the hippocampus, one of the central limbic regions involved in regulation of emotions and mood. The exact cellular and molecular mechanisms underlying hippocampal plasticity in response to stress are yet to be fully characterized. In this study, we examined the genetic profile of micro-dissected subfields of post-mortem hippocampus from subjects diagnosed with MDD and comparison subjects matched for sex, race and age. Gene expression profiles of the dentate gyrus and CA1 were assessed by 48K human HEEBO whole genome microarrays and a subgroup of identified genes was confirmed by real-time polymerase chain reaction (qPCR). Pathway analysis revealed altered expression of several gene families, including cytoskeletal proteins involved in rearrangement of neuronal processes. Based on this and evidence of hippocampal neuronal atrophy in MDD, we focused on the expression of cytoskeletal, synaptic and glutamate receptor genes. Our findings demonstrate significant dysregulation of synaptic function/structure related genes SNAP25, DLG2 (SAP93), and MAP1A, and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and GLUR3. Several of these human target genes were similarly dysregulated in a rat model of chronic unpredictable stress and the effects reversed by antidepressant treatment. Together, these studies provide new evidence that disruption of synaptic and glutamatergic signalling pathways contribute to the pathophysiology underlying MDD and provide interesting targets for novel therapeutic interventions. [PUBLICATION ABSTRACT] Major depressive disorder (MDD) has been linked to changes in function and activity of the hippocampus, one of the central limbic regions involved in regulation of emotions and mood. The exact cellular and molecular mechanisms underlying hippocampal plasticity in response to stress are yet to be fully characterized. In this study, we examined the genetic profile of micro-dissected subfields of post-mortem hippocampus from subjects diagnosed with MDD and comparison subjects matched for sex, race and age. Gene expression profiles of the dentate gyrus and CA1 were assessed by 48K human HEEBO whole genome microarrays and a subgroup of identified genes was confirmed by real-time polymerase chain reaction (qPCR). Pathway analysis revealed altered expression of several gene families, including cytoskeletal proteins involved in rearrangement of neuronal processes. Based on this and evidence of hippocampal neuronal atrophy in MDD, we focused on the expression of cytoskeletal, synaptic and glutamate receptor genes. Our findings demonstrate significant dysregulation of synaptic function/structure related genes SNAP25, DLG2 (SAP93), and MAP1A, and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and GLUR3. Several of these human target genes were similarly dysregulated in a rat model of chronic unpredictable stress and the effects reversed by antidepressant treatment. Together, these studies provide new evidence that disruption of synaptic and glutamatergic signalling pathways contribute to the pathophysiology underlying MDD and provide interesting targets for novel therapeutic interventions.Major depressive disorder (MDD) has been linked to changes in function and activity of the hippocampus, one of the central limbic regions involved in regulation of emotions and mood. The exact cellular and molecular mechanisms underlying hippocampal plasticity in response to stress are yet to be fully characterized. In this study, we examined the genetic profile of micro-dissected subfields of post-mortem hippocampus from subjects diagnosed with MDD and comparison subjects matched for sex, race and age. Gene expression profiles of the dentate gyrus and CA1 were assessed by 48K human HEEBO whole genome microarrays and a subgroup of identified genes was confirmed by real-time polymerase chain reaction (qPCR). Pathway analysis revealed altered expression of several gene families, including cytoskeletal proteins involved in rearrangement of neuronal processes. Based on this and evidence of hippocampal neuronal atrophy in MDD, we focused on the expression of cytoskeletal, synaptic and glutamate receptor genes. Our findings demonstrate significant dysregulation of synaptic function/structure related genes SNAP25, DLG2 (SAP93), and MAP1A, and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and GLUR3. Several of these human target genes were similarly dysregulated in a rat model of chronic unpredictable stress and the effects reversed by antidepressant treatment. Together, these studies provide new evidence that disruption of synaptic and glutamatergic signalling pathways contribute to the pathophysiology underlying MDD and provide interesting targets for novel therapeutic interventions. |
| Author | Jurjus, George J. Banasr, Mounira Simen, Arthur A. Stockmeier, Craig A. Overholser, James C. Duman, Ronald S. Newton, Samuel S. Duric, Vanja Dieter, Lesa |
| AuthorAffiliation | 1 Department of Psychiatry, Yale University, New Haven, CT, USA 2 Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA 3 Department of Psychiatry, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA 4 Department of Psychology, Case Western Reserve University, Cleveland, OH, USA |
| AuthorAffiliation_xml | – name: 1 Department of Psychiatry, Yale University, New Haven, CT, USA – name: 3 Department of Psychiatry, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA – name: 2 Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA – name: 4 Department of Psychology, Case Western Reserve University, Cleveland, OH, USA |
| Author_xml | – sequence: 1 givenname: Vanja surname: Duric fullname: Duric, Vanja organization: 1Department of Psychiatry, Yale University, New Haven, CT, USA – sequence: 2 givenname: Mounira surname: Banasr fullname: Banasr, Mounira organization: 1Department of Psychiatry, Yale University, New Haven, CT, USA – sequence: 3 givenname: Craig A. surname: Stockmeier fullname: Stockmeier, Craig A. organization: 2Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA – sequence: 4 givenname: Arthur A. surname: Simen fullname: Simen, Arthur A. organization: 1Department of Psychiatry, Yale University, New Haven, CT, USA – sequence: 5 givenname: Samuel S. surname: Newton fullname: Newton, Samuel S. organization: 1Department of Psychiatry, Yale University, New Haven, CT, USA – sequence: 6 givenname: James C. surname: Overholser fullname: Overholser, James C. organization: 4Department of Psychology, Case Western Reserve University, Cleveland, OH, USA – sequence: 7 givenname: George J. surname: Jurjus fullname: Jurjus, George J. organization: 3Department of Psychiatry, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA – sequence: 8 givenname: Lesa surname: Dieter fullname: Dieter, Lesa organization: 4Department of Psychology, Case Western Reserve University, Cleveland, OH, USA – sequence: 9 givenname: Ronald S. surname: Duman fullname: Duman, Ronald S. email: ronald.duman@yale.edu organization: 1Department of Psychiatry, Yale University, New Haven, CT, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22339950$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.biopsych.2003.08.015 10.1523/JNEUROSCI.16-06-01982.1996 10.1523/JNEUROSCI.18-18-07394.1998 10.1093/biostatistics/kxh018 10.1016/S1471-4892(01)00116-3 10.1038/mp.2008.106 10.1016/j.biopsych.2007.03.017 10.1111/j.1749-6632.1997.tb52357.x 10.1017/S1461145709991076 10.1016/j.pharmthera.2005.11.006 10.1097/01.wnr.0000227994.07799.6c 10.1385/NMM:5:1:011 10.1038/sj.npp.1301574 10.1016/0169-328X(95)00264-S 10.2174/187152707783220929 10.1097/00001756-200109170-00043 10.1038/sj.mp.4001158 10.1016/0165-0173(90)90013-E 10.1038/nm.2219 10.1016/S1385-299X(02)00148-4 10.1196/annals.1300.001 10.1111/j.1601-183X.2007.00316.x 10.1159/000077365 10.1074/jbc.M709639200 10.1002/syn.20329 10.1176/appi.ajp.159.3.419 10.1016/0091-3057(91)90599-W 10.1016/j.pnpbp.2008.10.005 10.1001/jama.289.23.3095 10.1046/j.1471-4159.2003.01987.x 10.1016/S0193-953X(05)70271-9 10.1385/MN:34:2:137 10.2515/therapie:2005065 10.1007/s00213-007-0710-6 10.1016/0920-1211(93)90046-A 10.1016/S0193-953X(05)70283-5 10.1038/sj.tpj.6500135 10.1016/j.biopsych.2004.08.022 10.1016/j.neulet.2004.09.035 10.1016/S0006-3223(03)00117-3 10.1038/sj.mp.4001471 10.1016/0006-8993(92)91597-8 10.1111/j.1749-6632.1991.tb25914.x 10.1016/S0278-5846(03)00027-7 10.1016/j.biopsych.2008.06.008 10.1016/j.biopsych.2005.01.016 10.1017/S1092852900017454 10.1016/S0361-9230(01)00523-8 10.1038/mp.2010.44 10.1016/j.neuron.2007.07.041 10.1016/S0006-3223(03)00420-7 10.1358/dnp.2007.20.9.1162244 10.1097/FBP.0b013e3282ee2aa8 10.1016/S0092-8674(01)00406-8 10.1016/0091-3057(95)02135-3 10.1093/hmg/ddg162 10.1016/j.biopsych.2010.12.015 10.1007/s007020170077 10.1159/000087097 10.1016/j.biopsych.2003.09.017 10.1176/appi.ajp.160.8.1516 10.1001/archpsyc.1997.01830190015002 10.1016/j.neuron.2009.08.008 10.1016/S0304-3940(99)00006-3 10.1016/0959-4388(94)90101-5 10.1073/pnas.93.9.3908 10.31887/DCNS.2009.11.3/rsduman 10.1016/S0306-4522(00)00460-7 10.4088/JCP.v64n1211 10.1016/j.biopsych.2007.02.006 10.1523/JNEUROSCI.23-34-10841.2003 10.1073/pnas.052712799 10.1073/pnas.1530509100 10.1016/S0091-3057(01)00745-6 10.1016/S0014-2999(99)00163-6 10.1016/j.brainres.2006.09.011 10.1016/S0022-3956(03)00050-5 10.1038/sj.tpj.6500229 |
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| References | Rosenzweig-Lipson, Dunlop, Marquis 2007; 20 Benowitz, Perrone-Bizzozero 1991; 627 Greenberg, Kessler, Birnbaum, Leong 2003; 64 Jones, Blackburn 2002; 71 Bernard, Kerman, Thompson, Jones 2010; 16 Lopez, Vazquez, Chalmers, Watson 1997; 836 Wang, Yang, Dong, Cao 2006; 17 Stockmeier, Mahajan, Konick, Overholser 2004; 56 Lajoie-Mazenc, Tovar, Penary, Lortal 2008; 283 Duman, Heninger, Nestler 1997; 54 Ossowska, Nowa, Kata, Klenk-Majewska 2001; 108 Watanabe, Gould, McEwen 1992; 588 Law, Deakin 2001; 12 Fava, Davidson 1996; 19 Errico, Crozier, Plummer, Cowen 2001; 102 Banasr, Duman 2007; 6 Lucas, Rymar, Du, Mnie-Filali 2007; 55 McCullumsmith, Kristiansen, Beneyto, Scarr 2007; 1127 Heisler, Zhou, Bajwa, Hsu 2007; 6 Duman 2009; 11 First, Donovan, Frances 1996; 19 Murua, Gomez, Andrea, Molina 1991; 38 Duman 2004; 5 Rosel, Arranz, Urretavizcaya, Oros 2004; 49 Feyissa, Chandran, Stockmeier, Karolewicz 2009; 33 Pandey, Dwivedi, Rizavi, Ren 2002; 159 Banasr, Chowdhury, Terwilliger, Newton 2010; 15 Storey, Tibshirani 2003; 100 Tucker 1990; 15 Thompson, Egbufoama, Vawter 2003; 27 Newton, Collier, Hunsberger, Adams 2003; 23 Rosenzweig-Lipson, Sabb, Stack, Mitchell 2007; 192 Yamada, Takahashi, Tsunoda, Nishioka 2002; 2 Coppen, Doogan 1988; 49 Morris, Kandpal, Ma, Austin 2003; 12 Magarinos, Deslandes, McEwen 1999; 371 Rapp, Baader, Hu, Jennen-Steinmetz 2004; 4 Nudmamud-Thanoi, Reynolds 2004; 372 Beneyto, Meador-Woodruff 2006; 60 Banasr, Duman 2008; 64 Li, Liu, Dwyer, Banasr 2011; 69 Stockmeier, Shapiro, Dilley, Kolli 1998; 18 Vawter, Thatcher, Usen, Hyde 2002; 7 Bear, Malenka 1994; 4 Neumeister, Wood, Bonne, Nugent 2005; 57 Little 2009; 80 Hashimoto, Sawa, Iyo 2007; 62 Hsiung, Adlersberg, Arango, Mann 2003; 87 Pittenger, Duman 2008; 33 Cui, Hwang, Qiu, Blades 2005; 6 Sheline, Gado, Kraemer 2003; 160 Sheng, Lee 2001; 105 Bruneau, Akaaboune 2006; 34 Sheline, Wang, Gado, Csernansky 1996; 93 Millan 2005; 60 Naylor, Stewart, Wright, Pearson 1996; 35 Schmidt, Duman 2007; 18 Stockmeier 2003; 37 Koo, Duman 2009; 10 Lopez-Figueroa, Norton, Lopez-Figueroa, Armellini-Dodel 2004; 55 Meador-Woodruff, Hogg, Smith 2001; 55 Duric, Banasr, Licznerski, Schmidt 2010; 16 Svenningsson, Tzavara, Witkin, Fienberg 2002; 99 Millan 2006; 110 Duman 2002; 7 Manji, Quiroz, Sporn, Payne 2003; 53 Vaidya, Terwilliger, Duman 1999; 262 Wong, Smith, Licinio, Doi 1993; 14 Malenka 2003; 1003 Simon 2003; 54 Newton, Dow, Terwilliger, Duman 2002; 9 Mintun, Sheline, Moerlein, Vlassenko 2004; 55 Farley, Apazoglou, Witkin, Giros 2010; 13 Banasr, Valentine, Li, Gourley 2007; 62 Wenthold, Petralia, Blahos, Niedzielski 1996; 16 Graeff, Guimaraes, De Andrade, Deakin 1996; 54 Willner 2005; 52 Kessler, Berglund, Demler, Jin 2003; 289 Kim, Duan, Liu, Jang 2009; 63 Middlemiss, Price, Watson 2002; 2 Knable, Barci, Webster, Meador-Woodruff 2004; 9 Meador-Woodruff (2019101113393344800_ref43) 2001; 55 McCullumsmith (2019101113393344800_ref39) 2007; 1127 Wang (2019101113393344800_ref76) 2006; 17 Malenka (2019101113393344800_ref41) 2003; 1003 Willner (2019101113393344800_ref79) 2005; 52 Vaidya (2019101113393344800_ref74) 1999; 262 Duman (2019101113393344800_ref12) 2002; 7 Knable (2019101113393344800_ref30) 2004; 9 Murua (2019101113393344800_ref49) 1991; 38 Tucker (2019101113393344800_ref73) 1990; 15 Pandey (2019101113393344800_ref56) 2002; 159 Cui (2019101113393344800_ref11) 2005; 6 Koo (2019101113393344800_ref31) 2009; 10 Schmidt (2019101113393344800_ref62) 2007; 18 Bear (2019101113393344800_ref5) 1994; 4 Storey (2019101113393344800_ref70) 2003; 100 Yamada (2019101113393344800_ref81) 2002; 2 Duman (2019101113393344800_ref15) 1997; 54 Morris (2019101113393344800_ref48) 2003; 12 Rosel (2019101113393344800_ref59) 2004; 49 Wong (2019101113393344800_ref80) 1993; 14 Coppen (2019101113393344800_ref10) 1988; 49 Newton (2019101113393344800_ref52) 2003; 23 Wenthold (2019101113393344800_ref78) 1996; 16 Kim (2019101113393344800_ref29) 2009; 63 Stockmeier (2019101113393344800_ref69) 1998; 18 Greenberg (2019101113393344800_ref23) 2003; 64 Ossowska (2019101113393344800_ref55) 2001; 108 Watanabe (2019101113393344800_ref77) 1992; 588 First (2019101113393344800_ref21) 1996; 19 Vawter (2019101113393344800_ref75) 2002; 7 Bruneau (2019101113393344800_ref9) 2006; 34 Banasr (2019101113393344800_ref2) 2007; 6 Banasr (2019101113393344800_ref3) 2008; 64 Beneyto (2019101113393344800_ref6) 2006; 60 Benowitz (2019101113393344800_ref7) 1991; 627 Lopez-Figueroa (2019101113393344800_ref37) 2004; 55 Banasr (2019101113393344800_ref1) 2010; 15 Duric (2019101113393344800_ref16) 2010; 16 Thompson (2019101113393344800_ref72) 2003; 27 Heisler (2019101113393344800_ref25) 2007; 6 Magarinos (2019101113393344800_ref40) 1999; 371 Banasr (2019101113393344800_ref4) 2007; 62 Hashimoto (2019101113393344800_ref24) 2007; 62 Fava (2019101113393344800_ref19) 1996; 19 Law (2019101113393344800_ref33) 2001; 12 Manji (2019101113393344800_ref42) 2003; 53 Rapp (2019101113393344800_ref58) 2004; 4 Stockmeier (2019101113393344800_ref68) 2004; 56 Jones (2019101113393344800_ref27) 2002; 71 Rosenzweig-Lipson (2019101113393344800_ref60) 2007; 20 Millan (2019101113393344800_ref46) 2006; 110 Lucas (2019101113393344800_ref38) 2007; 55 Pittenger (2019101113393344800_ref57) 2008; 33 Farley (2019101113393344800_ref18) 2010; 13 Neumeister (2019101113393344800_ref51) 2005; 57 Newton (2019101113393344800_ref53) 2002; 9 Graeff (2019101113393344800_ref22) 1996; 54 Mintun (2019101113393344800_ref47) 2004; 55 Stockmeier (2019101113393344800_ref67) 2003; 37 APA (2019101113393344800_ref1a) 1994 Little (2019101113393344800_ref35) 2009; 80 Duman (2019101113393344800_ref14) 2009; 11 Simon (2019101113393344800_ref66) 2003; 54 Hsiung (2019101113393344800_ref26) 2003; 87 Feyissa (2019101113393344800_ref20) 2009; 33 Sheline (2019101113393344800_ref64) 1996; 93 Duman (2019101113393344800_ref13) 2004; 5 Li (2019101113393344800_ref34) 2011; 69 Millan (2019101113393344800_ref45) 2005; 60 Sheline (2019101113393344800_ref63) 2003; 160 Svenningsson (2019101113393344800_ref71) 2002; 99 Lopez (2019101113393344800_ref36) 1997; 836 Errico (2019101113393344800_ref17) 2001; 102 Bernard (2019101113393344800_ref8) 2010; 16 Nudmamud-Thanoi (2019101113393344800_ref54) 2004; 372 Middlemiss (2019101113393344800_ref44) 2002; 2 Rosenzweig-Lipson (2019101113393344800_ref61) 2007; 192 Naylor (2019101113393344800_ref50) 1996; 35 Sheng (2019101113393344800_ref65) 2001; 105 Kessler (2019101113393344800_ref28) 2003; 289 Lajoie-Mazenc (2019101113393344800_ref32) 2008; 283 12691775 - Prog Neuropsychopharmacol Biol Psychiatry. 2003 May;27(3):411-7 18825147 - Mol Psychiatry. 2010 May;15(5):501-11 2282447 - Brain Res Brain Res Rev. 1990 May-Aug;15(2):101-20 18639237 - Biol Psychiatry. 2008 Nov 15;64(10):863-70 14708030 - Mol Psychiatry. 2004 Jun;9(6):609-20, 544 8827185 - Psychiatr Clin North Am. 1996 Jun;19(2):179-200 11341483 - J Neural Transm (Vienna). 2001;108(3):311-9 14744461 - Biol Psychiatry. 2004 Feb 1;55(3):217-24 12849929 - J Psychiatr Res. 2003 Sep-Oct;37(5):357-73 19778506 - Neuron. 2009 Sep 24;63(6):761-73 11588613 - Neuroreport. 2001 Sep 17;12(13):2971-4 18992785 - Prog Neuropsychopharmacol Biol Psychiatry. 2009 Feb 1;33(1):70-5 12140780 - Mol Psychiatry. 2002;7(6):571-8 21292242 - Biol Psychiatry. 2011 Apr 15;69(8):754-61 15522247 - Biol Psychiatry. 2004 Nov 1;56(9):640-50 8717376 - Brain Res Mol Brain Res. 1996 Jan;35(1-2):349-53 10076858 - Neurosci Lett. 1999 Feb 26;262(1):1-4 15531111 - Neurosci Lett. 2004 Nov 30;372(1-2):173-7 11888547 - Pharmacol Biochem Behav. 2002 Apr;71(4):555-68 12969265 - J Neurochem. 2003 Oct;87(1):182-94 17851537 - Neuropsychopharmacology. 2008 Jan;33(1):88-109 12113781 - Brain Res Brain Res Protoc. 2002 Jun;9(3):214-9 20953200 - Nat Med. 2010 Nov;16(11):1328-32 15618528 - Biostatistics. 2005 Jan;6(1):59-75 10357248 - Eur J Pharmacol. 1999 Apr 29;371(2-3):113-22 9236543 - Arch Gen Psychiatry. 1997 Jul;54(7):597-606 14728109 - J Clin Psychiatry. 2003 Dec;64(12):1465-75 17451451 - Genes Brain Behav. 2007 Jul;6(5):491-6 17113057 - Brain Res. 2007 Jan 5;1127(1):108-18 16433010 - Therapie. 2005 Sep-Oct;60(5):441-60 8504792 - Epilepsy Res. 1993 Mar;14(3):221-7 16522330 - Pharmacol Ther. 2006 May;110(2):135-370 12893097 - Biol Psychiatry. 2003 Aug 1;54(3):208-15 8632988 - Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3908-13 18056259 - J Biol Chem. 2008 Feb 15;283(7):4155-64 8677218 - Psychiatr Clin North Am. 1996 Mar;19(1):29-39 17574216 - Biol Psychiatry. 2007 Dec 1;62(11):1310-6 19877493 - Dialogues Clin Neurosci. 2009;11(3):239-55 11439178 - Cell. 2001 Jun 29;105(7):825-8 20059803 - Int J Neuropsychopharmacol. 2010 Oct;13(9):1207-18 15118356 - Neuropsychobiology. 2004;49(4):189-95 9736659 - J Neurosci. 1998 Sep 15;18(18):7394-401 12812986 - Hum Mol Genet. 2003 Jul 1;12(13):1591-608 8604042 - J Neurosci. 1996 Mar 15;16(6):1982-9 14645477 - J Neurosci. 2003 Nov 26;23(34):10841-51 17785179 - Neuron. 2007 Sep 6;55(5):712-25 12900317 - Am J Psychiatry. 2003 Aug;160(8):1516-8 7919934 - Curr Opin Neurobiol. 1994 Jun;4(3):389-99 18176661 - Drug News Perspect. 2007 Nov;20(9):565-71 12629503 - Pharmacogenomics J. 2002;2(6):377-82 11880651 - Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3182-7 3045111 - J Clin Psychiatry. 1988 Aug;49 Suppl:4-11 11786304 - Curr Opin Pharmacol. 2002 Feb;2(1):18-22 20386568 - Mol Psychiatry. 2011 Jun;16(6):634-46 19579172 - Curr Opin Investig Drugs. 2009 Jul;10(7):664-71 14744462 - Biol Psychiatry. 2004 Feb 1;55(3):225-33 15820716 - Biol Psychiatry. 2005 Apr 15;57(8):935-7 16951582 - Neuroreport. 2006 Aug 21;17(12):1343-6 12706957 - Biol Psychiatry. 2003 Apr 15;53(8):707-42 15220856 - CNS Spectr. 2002 Feb;7(2):140-2, 144-7 11576760 - Brain Res Bull. 2001 Jul 15;55(5):631-40 18045159 - CNS Neurol Disord Drug Targets. 2007 Oct;6(5):311-20 2017440 - Pharmacol Biochem Behav. 1991 Jan;38(1):125-30 19621857 - Am Fam Physician. 2009 Jul 15;80(2):167-72 12883005 - Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5 14708000 - Pharmacogenomics J. 2004;4(2):110-3 1393587 - Brain Res. 1992 Aug 21;588(2):341-5 16037678 - Neuropsychobiology. 2005;52(2):90-110 11166122 - Neuroscience. 2001;102(2):361-7 17585885 - Biol Psychiatry. 2007 Sep 1;62(5):496-504 1831963 - Ann N Y Acad Sci. 1991;627:58-74 9616796 - Ann N Y Acad Sci. 1997 Dec 29;836:106-34 17297636 - Psychopharmacology (Berl). 2007 Jun;192(2):159-70 8728550 - Pharmacol Biochem Behav. 1996 May;54(1):129-41 11870006 - Am J Psychiatry. 2002 Mar;159(3):419-29 15001809 - Neuromolecular Med. 2004;5(1):11-25 17762509 - Behav Pharmacol. 2007 Sep;18(5-6):391-418 17220535 - Mol Neurobiol. 2006 Oct;34(2):137-51 14684431 - Ann N Y Acad Sci. 2003 Nov;1003:1-11 12813115 - JAMA. 2003 Jun 18;289(23):3095-105 16983646 - Synapse. 2006 Dec 15;60(8):585-98 |
| References_xml | – volume: 33 start-page: 70 year: 2009 end-page: 75 article-title: Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression publication-title: Progress in Neuro-psychopharmacology and Biological Psychiatry – volume: 52 start-page: 90 year: 2005 end-page: 110 article-title: Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS publication-title: Neuropsychobiology – volume: 1127 start-page: 108 year: 2007 end-page: 118 article-title: Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder publication-title: Brain Research – volume: 1003 start-page: 1 year: 2003 end-page: 11 article-title: Synaptic plasticity and AMPA receptor trafficking publication-title: Annals of the New York Academy of Sciences – volume: 54 start-page: 129 year: 1996 end-page: 141 article-title: Role of 5-HT in stress, anxiety, and depression publication-title: Pharmacology, Biochemistry, and Behavior – volume: 49 start-page: 4 year: 1988 end-page: 11 article-title: Serotonin and its place in the pathogenesis of depression publication-title: Journal of Clinical Psychiatry – volume: 93 start-page: 3908 year: 1996 end-page: 3913 article-title: Hippocampal atrophy in recurrent major depression publication-title: Proceedings of the National Academy of Sciences USA – volume: 57 start-page: 935 year: 2005 end-page: 937 article-title: Reduced hippocampal volume in unmedicated, remitted patients with major depression vs. control subjects publication-title: Biological Psychiatry – volume: 160 start-page: 1516 year: 2003 end-page: 1518 article-title: Untreated depression and hippocampal volume loss publication-title: American Journal of Psychiatry – volume: 588 start-page: 341 year: 1992 end-page: 345 article-title: Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons publication-title: Brain Research – volume: 836 start-page: 106 year: 1997 end-page: 134 article-title: Regulation of 5-HT receptors and the hypothalamic-pituitary-adrenal axis. Implications for the neurobiology of suicide publication-title: Annals of the New York Academy of Sciences – volume: 54 start-page: 208 year: 2003 end-page: 215 article-title: Social and economic burden of mood disorders publication-title: Biological Psychiatry – volume: 262 start-page: 1 year: 1999 end-page: 4 article-title: Role of 5-HT2A receptors in the stress-induced down-regulation of brain-derived neurotrophic factor expression in rat hippocampus publication-title: Neuroscience Letters – volume: 62 start-page: 496 year: 2007 end-page: 504 article-title: Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat publication-title: Biological Psychiatry – volume: 60 start-page: 441 year: 2005 end-page: 460 article-title: Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies publication-title: Therapie – volume: 18 start-page: 391 year: 2007 end-page: 418 article-title: The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior publication-title: Behavioural Pharmacology – volume: 16 start-page: 1328 year: 2010 end-page: 1332 article-title: A negative regulator of MAP kinase causes depressive behavior publication-title: Nature Medicine – volume: 87 start-page: 182 year: 2003 end-page: 194 article-title: Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphati-dylinositol 3-kinase, Akt and mitogen-activated protein kinase publication-title: Journal of Neurochemistry – volume: 12 start-page: 1591 year: 2003 end-page: 1608 article-title: DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation publication-title: Human Molecular Genetics – volume: 62 start-page: 1310 year: 2007 end-page: 1316 article-title: Increased levels of glutamate in brains from patients with mood disorders publication-title: Biological Psychiatry – volume: 38 start-page: 125 year: 1991 end-page: 130 article-title: Shuttle-box deficits induced by chronic variable stress: reversal by imipramine administration publication-title: Pharmacology, Biochemistry, and Behavior – volume: 289 start-page: 3095 year: 2003 end-page: 3105 article-title: The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R) publication-title: Journal of the American Medical Association – volume: 2 start-page: 18 year: 2002 end-page: 22 article-title: Serotonergic targets in depression publication-title: Current Opinion in Pharmacology – volume: 4 start-page: 110 year: 2004 end-page: 113 article-title: Differential regulation of synaptic vesicle proteins by antidepressant drugs publication-title: Pharmacogenomics Journal – volume: 15 start-page: 101 year: 1990 end-page: 120 article-title: The roles of microtubule-associated proteins in brain morphogenesis: a review publication-title: Brain Research Review – volume: 6 start-page: 491 year: 2007 end-page: 496 article-title: Serotonin 5-HT(2C) receptors regulate anxiety-like behavior publication-title: Genes, Brain, and Behavior – volume: 63 start-page: 761 year: 2009 end-page: 773 article-title: DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 publication-title: Neuron – volume: 18 start-page: 7394 year: 1998 end-page: 7401 article-title: Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity publication-title: Journal of Neuroscience – volume: 56 start-page: 640 year: 2004 end-page: 650 article-title: Cellular changes in the postmortem hippocampus in major depression publication-title: Biological Psychiatry – volume: 371 start-page: 113 year: 1999 end-page: 122 article-title: Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress publication-title: European Journal of Pharmacology – volume: 372 start-page: 173 year: 2004 end-page: 177 article-title: The NR1 subunit of the glutamate/NMDA receptor in the superior temporal cortex in schizophrenia and affective disorders publication-title: Neuroscience Letters – volume: 55 start-page: 712 year: 2007 end-page: 725 article-title: Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action publication-title: Neuron – volume: 19 start-page: 179 year: 1996 end-page: 200 article-title: Definition and epidemiology of treatment-resistant depression publication-title: Psychiatric Clinics of North America – volume: 102 start-page: 361 year: 2001 end-page: 367 article-title: 5-HT(7) receptors activate the mitogen activated protein kinase extracellular signal related kinase in cultured rat hippocampal neurons publication-title: Neuroscience – volume: 110 start-page: 135 year: 2006 end-page: 370 article-title: Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application publication-title: Pharmacology and Therapeutics – volume: 15 start-page: 501 year: 2010 end-page: 511 article-title: Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole publication-title: Molecular Psychiatry – volume: 53 start-page: 707 year: 2003 end-page: 742 article-title: Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression publication-title: Biological Psychiatry – volume: 49 start-page: 189 year: 2004 end-page: 195 article-title: Altered 5-HT2A and 5-HT4 postsynaptic receptors and their intracellular signalling systems IP3 and cAMP in brains from depressed violent suicide victims publication-title: Neuropsychobiology – volume: 60 start-page: 585 year: 2006 end-page: 598 article-title: Lamina-specific abnormalities of AMPA receptor trafficking and signaling molecule transcripts in the prefrontal cortex in schizophrenia publication-title: Synapse – volume: 20 start-page: 565 year: 2007 end-page: 571 article-title: 5-HT2C receptor agonists as an innovative approach for psychiatric disorders publication-title: Drug News and Perspectives – volume: 80 start-page: 167 year: 2009 end-page: 172 article-title: Treatment-resistant depression publication-title: American Family Physician – volume: 99 start-page: 3182 year: 2002 end-page: 3187 article-title: Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac) publication-title: Proceedings of the National Academy of Sciences USA – volume: 55 start-page: 217 year: 2004 end-page: 224 article-title: Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography publication-title: Biological Psychiatry – volume: 16 start-page: 634 year: 2010 end-page: 646 article-title: Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression publication-title: Molecular Psychiatry – volume: 192 start-page: 159 year: 2007 end-page: 170 article-title: Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents publication-title: Psychopharmacology – volume: 627 start-page: 58 year: 1991 end-page: 74 article-title: The relationship of GAP-43 to the development and plasticity of synaptic connections publication-title: Annals of the New York Academy of Sciences – volume: 159 start-page: 419 year: 2002 end-page: 429 article-title: Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims publication-title: American Journal of Psychiatry – volume: 12 start-page: 2971 year: 2001 end-page: 2974 article-title: Asymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses publication-title: Neuroreport – volume: 37 start-page: 357 year: 2003 end-page: 373 article-title: Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter publication-title: Journal of Psychiatric Research – volume: 2 start-page: 377 year: 2002 end-page: 382 article-title: Differential expression of VAMP2/synaptobrevin-2 after antidepressant and electroconvulsive treatment in rat frontal cortex publication-title: Pharmacogenomics Journal – volume: 6 start-page: 59 year: 2005 end-page: 75 article-title: Improved statistical tests for differential gene expression by shrinking variance components estimates publication-title: Biostatistics – volume: 11 start-page: 239 year: 2009 end-page: 255 article-title: Neuronal damage and protection in the pathophysiology and treatment of psychiatric illness: stress and depression publication-title: Dialogues in Clinical Neuroscience – volume: 105 start-page: 825 year: 2001 end-page: 828 article-title: AMPA receptor trafficking and the control of synaptic transmission publication-title: Cell – volume: 69 start-page: 754 year: 2011 end-page: 761 article-title: Glutamate N-methyl-d-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure publication-title: Biological Psychiatry – volume: 108 start-page: 311 year: 2001 end-page: 319 article-title: Brain monoamine receptors in a chronic unpredictable stress model in rats publication-title: Journal of Neural Transmission – volume: 283 start-page: 4155 year: 2008 end-page: 4164 article-title: MAP1A light chain-2 interacts with GTP-RhoB to control epidermal growth factor (EGF)-dependent EGF receptor signaling publication-title: Journal of Biological Chemistry – volume: 64 start-page: 863 year: 2008 end-page: 870 article-title: Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors publication-title: Biological Psychiatry – volume: 33 start-page: 88 year: 2008 end-page: 109 article-title: Stress, depression, and neuroplasticity: a convergence of mechanisms publication-title: Neuropsychopharmacology – volume: 6 start-page: 311 year: 2007 end-page: 320 article-title: Regulation of neurogenesis and gliogenesis by stress and antidepressant treatment publication-title: CNS and Neurological Disorders Drug Targets – volume: 9 start-page: 214 year: 2002 end-page: 219 article-title: A simplified method for combined immunohistochemistry and in-situ hybridization in fresh-frozen, cryocut mouse brain sections publication-title: Brain Research Protocols – volume: 17 start-page: 1343 year: 2006 end-page: 1346 article-title: NR2B-containing N-methyl-d-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo publication-title: Neuroreport – volume: 64 start-page: 1465 year: 2003 end-page: 1475 article-title: The economic burden of depression in the United States: how did it change between 1990 and 2000? publication-title: Journal of Clinical Psychiatry – volume: 4 start-page: 389 year: 1994 end-page: 399 article-title: Synaptic plasticity: LTP and LTD publication-title: Current Opinion in Neurobiology – volume: 14 start-page: 221 year: 1993 end-page: 227 article-title: Differential effects of kindled and electrically induced seizures on a glutamate receptor (GluR1) gene expression publication-title: Epilepsy Research – volume: 13 start-page: 1207 year: 2010 end-page: 1218 article-title: Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm publication-title: International Journal of Neuropsychopharmacology – volume: 16 start-page: 1982 year: 1996 end-page: 1989 article-title: Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons publication-title: Journal of Neuroscience – volume: 34 start-page: 137 year: 2006 end-page: 151 article-title: Running to stand still: ionotropic receptor dynamics at central and peripheral synapses publication-title: Molecular Neurobiology – volume: 55 start-page: 631 year: 2001 end-page: 640 article-title: Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder publication-title: Brain Research Bulletin – volume: 7 start-page: 140 144 year: 2002 end-page: 142 147 article-title: Structural alterations in depression: cellular mechanisms underlying pathology and treatment of mood disorders publication-title: CNS Spectrums – volume: 9 start-page: 609 year: 2004 end-page: 620 article-title: Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium publication-title: Molecular Psychiatry – volume: 19 start-page: 29 year: 1996 end-page: 39 article-title: Nosology of chronic mood disorders publication-title: Psychiatric Clinics of North America – volume: 100 start-page: 9440 year: 2003 end-page: 9445 article-title: Statistical significance for genomewide studies publication-title: Proceedings of the National Academy of Sciences USA – volume: 54 start-page: 597 year: 1997 end-page: 606 article-title: A molecular and cellular theory of depression publication-title: Archives of General Psychiatry – volume: 7 start-page: 571 year: 2002 end-page: 578 article-title: Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia publication-title: Molecular Psychiatry – volume: 55 start-page: 225 year: 2004 end-page: 233 article-title: Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia publication-title: Biological Psychiatry – volume: 35 start-page: 349 year: 1996 end-page: 353 article-title: Repeated ECS induces GluR1 mRNA but not NMDAR1A-G mRNA in the rat hippocampus publication-title: Brain Research – volume: 71 start-page: 555 year: 2002 end-page: 568 article-title: The medical benefit of 5-HT research publication-title: Pharmacology, Biochemistry, and Behavior – volume: 10 start-page: 664 year: 2009 end-page: 671 article-title: Evidence for IL-1 receptor blockade as a therapeutic strategy for the treatment of depression publication-title: Current Opinion in Investigational Drugs – volume: 27 start-page: 411 year: 2003 end-page: 417 article-title: SNAP-25 reduction in the hippocampus of patients with schizophrenia publication-title: Progress in Neuro-psychopharmacology and Biological Psychiatry – volume: 23 start-page: 10841 year: 2003 end-page: 10851 article-title: Gene profile of electroconvulsive seizures: induction of neurotrophic and angiogenic factors publication-title: Journal of Neuroscience – volume: 5 start-page: 11 year: 2004 end-page: 25 article-title: Role of neurotrophic factors in the etiology and treatment of mood disorders publication-title: Neuromolecular Medicine – volume: 55 start-page: 217 year: 2004 ident: 2019101113393344800_ref47 article-title: Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography publication-title: Biological Psychiatry doi: 10.1016/j.biopsych.2003.08.015 – volume: 16 start-page: 1982 year: 1996 ident: 2019101113393344800_ref78 article-title: Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.16-06-01982.1996 – volume: 80 start-page: 167 year: 2009 ident: 2019101113393344800_ref35 article-title: Treatment-resistant depression publication-title: American Family Physician – volume: 18 start-page: 7394 year: 1998 ident: 2019101113393344800_ref69 article-title: Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.18-18-07394.1998 – volume: 6 start-page: 59 year: 2005 ident: 2019101113393344800_ref11 article-title: Improved statistical tests for differential gene expression by shrinking variance components estimates publication-title: Biostatistics doi: 10.1093/biostatistics/kxh018 – volume: 2 start-page: 18 year: 2002 ident: 2019101113393344800_ref44 article-title: Serotonergic targets in depression publication-title: Current Opinion in Pharmacology doi: 10.1016/S1471-4892(01)00116-3 – volume: 15 start-page: 501 year: 2010 ident: 2019101113393344800_ref1 article-title: Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole publication-title: Molecular Psychiatry doi: 10.1038/mp.2008.106 – volume: 62 start-page: 1310 year: 2007 ident: 2019101113393344800_ref24 article-title: Increased levels of glutamate in brains from patients with mood disorders publication-title: Biological Psychiatry doi: 10.1016/j.biopsych.2007.03.017 – volume: 836 start-page: 106 year: 1997 ident: 2019101113393344800_ref36 article-title: Regulation of 5-HT receptors and the hypothalamic-pituitary-adrenal axis. Implications for the neurobiology of suicide publication-title: Annals of the New York Academy of Sciences doi: 10.1111/j.1749-6632.1997.tb52357.x – volume: 13 start-page: 1207 year: 2010 ident: 2019101113393344800_ref18 article-title: Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm publication-title: International Journal of Neuropsychopharmacology doi: 10.1017/S1461145709991076 – volume: 110 start-page: 135 year: 2006 ident: 2019101113393344800_ref46 article-title: Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application publication-title: Pharmacology and Therapeutics doi: 10.1016/j.pharmthera.2005.11.006 – volume: 17 start-page: 1343 year: 2006 ident: 2019101113393344800_ref76 article-title: NR2B-containing N-methyl-d-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivo publication-title: Neuroreport doi: 10.1097/01.wnr.0000227994.07799.6c – volume: 5 start-page: 11 year: 2004 ident: 2019101113393344800_ref13 article-title: Role of neurotrophic factors in the etiology and treatment of mood disorders publication-title: Neuromolecular Medicine doi: 10.1385/NMM:5:1:011 – volume: 33 start-page: 88 year: 2008 ident: 2019101113393344800_ref57 article-title: Stress, depression, and neuroplasticity: a convergence of mechanisms publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301574 – volume: 35 start-page: 349 year: 1996 ident: 2019101113393344800_ref50 article-title: Repeated ECS induces GluR1 mRNA but not NMDAR1A-G mRNA in the rat hippocampus publication-title: Brain Research doi: 10.1016/0169-328X(95)00264-S – volume: 6 start-page: 311 year: 2007 ident: 2019101113393344800_ref2 article-title: Regulation of neurogenesis and gliogenesis by stress and antidepressant treatment publication-title: CNS and Neurological Disorders Drug Targets doi: 10.2174/187152707783220929 – volume: 12 start-page: 2971 year: 2001 ident: 2019101113393344800_ref33 article-title: Asymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses publication-title: Neuroreport doi: 10.1097/00001756-200109170-00043 – volume: 7 start-page: 571 year: 2002 ident: 2019101113393344800_ref75 article-title: Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia publication-title: Molecular Psychiatry doi: 10.1038/sj.mp.4001158 – volume: 15 start-page: 101 year: 1990 ident: 2019101113393344800_ref73 article-title: The roles of microtubule-associated proteins in brain morphogenesis: a review publication-title: Brain Research Review doi: 10.1016/0165-0173(90)90013-E – volume: 16 start-page: 1328 year: 2010 ident: 2019101113393344800_ref16 article-title: A negative regulator of MAP kinase causes depressive behavior publication-title: Nature Medicine doi: 10.1038/nm.2219 – volume: 9 start-page: 214 year: 2002 ident: 2019101113393344800_ref53 article-title: A simplified method for combined immunohistochemistry and in-situ hybridization in fresh-frozen, cryocut mouse brain sections publication-title: Brain Research Protocols doi: 10.1016/S1385-299X(02)00148-4 – volume: 1003 start-page: 1 year: 2003 ident: 2019101113393344800_ref41 article-title: Synaptic plasticity and AMPA receptor trafficking publication-title: Annals of the New York Academy of Sciences doi: 10.1196/annals.1300.001 – volume: 6 start-page: 491 year: 2007 ident: 2019101113393344800_ref25 article-title: Serotonin 5-HT(2C) receptors regulate anxiety-like behavior publication-title: Genes, Brain, and Behavior doi: 10.1111/j.1601-183X.2007.00316.x – volume: 49 start-page: 189 year: 2004 ident: 2019101113393344800_ref59 article-title: Altered 5-HT2A and 5-HT4 postsynaptic receptors and their intracellular signalling systems IP3 and cAMP in brains from depressed violent suicide victims publication-title: Neuropsychobiology doi: 10.1159/000077365 – volume: 283 start-page: 4155 year: 2008 ident: 2019101113393344800_ref32 article-title: MAP1A light chain-2 interacts with GTP-RhoB to control epidermal growth factor (EGF)-dependent EGF receptor signaling publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M709639200 – volume: 60 start-page: 585 year: 2006 ident: 2019101113393344800_ref6 article-title: Lamina-specific abnormalities of AMPA receptor trafficking and signaling molecule transcripts in the prefrontal cortex in schizophrenia publication-title: Synapse doi: 10.1002/syn.20329 – volume: 159 start-page: 419 year: 2002 ident: 2019101113393344800_ref56 article-title: Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims publication-title: American Journal of Psychiatry doi: 10.1176/appi.ajp.159.3.419 – volume: 38 start-page: 125 year: 1991 ident: 2019101113393344800_ref49 article-title: Shuttle-box deficits induced by chronic variable stress: reversal by imipramine administration publication-title: Pharmacology, Biochemistry, and Behavior doi: 10.1016/0091-3057(91)90599-W – volume: 33 start-page: 70 year: 2009 ident: 2019101113393344800_ref20 article-title: Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression publication-title: Progress in Neuro-psychopharmacology and Biological Psychiatry doi: 10.1016/j.pnpbp.2008.10.005 – volume: 289 start-page: 3095 year: 2003 ident: 2019101113393344800_ref28 article-title: The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R) publication-title: Journal of the American Medical Association doi: 10.1001/jama.289.23.3095 – volume: 87 start-page: 182 year: 2003 ident: 2019101113393344800_ref26 article-title: Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphati-dylinositol 3-kinase, Akt and mitogen-activated protein kinase publication-title: Journal of Neurochemistry doi: 10.1046/j.1471-4159.2003.01987.x – volume: 10 start-page: 664 year: 2009 ident: 2019101113393344800_ref31 article-title: Evidence for IL-1 receptor blockade as a therapeutic strategy for the treatment of depression publication-title: Current Opinion in Investigational Drugs – volume: 19 start-page: 29 year: 1996 ident: 2019101113393344800_ref21 article-title: Nosology of chronic mood disorders publication-title: Psychiatric Clinics of North America doi: 10.1016/S0193-953X(05)70271-9 – volume: 34 start-page: 137 year: 2006 ident: 2019101113393344800_ref9 article-title: Running to stand still: ionotropic receptor dynamics at central and peripheral synapses publication-title: Molecular Neurobiology doi: 10.1385/MN:34:2:137 – volume: 60 start-page: 441 year: 2005 ident: 2019101113393344800_ref45 article-title: Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies publication-title: Therapie doi: 10.2515/therapie:2005065 – volume: 192 start-page: 159 year: 2007 ident: 2019101113393344800_ref61 article-title: Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents publication-title: Psychopharmacology doi: 10.1007/s00213-007-0710-6 – volume: 14 start-page: 221 year: 1993 ident: 2019101113393344800_ref80 article-title: Differential effects of kindled and electrically induced seizures on a glutamate receptor (GluR1) gene expression publication-title: Epilepsy Research doi: 10.1016/0920-1211(93)90046-A – volume: 19 start-page: 179 year: 1996 ident: 2019101113393344800_ref19 article-title: Definition and epidemiology of treatment-resistant depression publication-title: Psychiatric Clinics of North America doi: 10.1016/S0193-953X(05)70283-5 – volume: 2 start-page: 377 year: 2002 ident: 2019101113393344800_ref81 article-title: Differential expression of VAMP2/synaptobrevin-2 after antidepressant and electroconvulsive treatment in rat frontal cortex publication-title: Pharmacogenomics Journal doi: 10.1038/sj.tpj.6500135 – volume: 56 start-page: 640 year: 2004 ident: 2019101113393344800_ref68 article-title: Cellular changes in the postmortem hippocampus in major depression publication-title: Biological Psychiatry doi: 10.1016/j.biopsych.2004.08.022 – volume: 372 start-page: 173 year: 2004 ident: 2019101113393344800_ref54 article-title: The NR1 subunit of the glutamate/NMDA receptor in the superior temporal cortex in schizophrenia and affective disorders publication-title: Neuroscience Letters doi: 10.1016/j.neulet.2004.09.035 – volume: 53 start-page: 707 year: 2003 ident: 2019101113393344800_ref42 article-title: Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression publication-title: Biological Psychiatry doi: 10.1016/S0006-3223(03)00117-3 – volume: 9 start-page: 609 year: 2004 ident: 2019101113393344800_ref30 article-title: Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium publication-title: Molecular Psychiatry doi: 10.1038/sj.mp.4001471 – volume: 588 start-page: 341 year: 1992 ident: 2019101113393344800_ref77 article-title: Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons publication-title: Brain Research doi: 10.1016/0006-8993(92)91597-8 – volume: 627 start-page: 58 year: 1991 ident: 2019101113393344800_ref7 article-title: The relationship of GAP-43 to the development and plasticity of synaptic connections publication-title: Annals of the New York Academy of Sciences doi: 10.1111/j.1749-6632.1991.tb25914.x – volume: 27 start-page: 411 year: 2003 ident: 2019101113393344800_ref72 article-title: SNAP-25 reduction in the hippocampus of patients with schizophrenia publication-title: Progress in Neuro-psychopharmacology and Biological Psychiatry doi: 10.1016/S0278-5846(03)00027-7 – volume: 64 start-page: 863 year: 2008 ident: 2019101113393344800_ref3 article-title: Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors publication-title: Biological Psychiatry doi: 10.1016/j.biopsych.2008.06.008 – volume: 57 start-page: 935 year: 2005 ident: 2019101113393344800_ref51 article-title: Reduced hippocampal volume in unmedicated, remitted patients with major depression vs. control subjects publication-title: Biological Psychiatry doi: 10.1016/j.biopsych.2005.01.016 – volume: 7 start-page: 140 year: 2002 ident: 2019101113393344800_ref12 article-title: Structural alterations in depression: cellular mechanisms underlying pathology and treatment of mood disorders publication-title: CNS Spectrums doi: 10.1017/S1092852900017454 – volume: 55 start-page: 631 year: 2001 ident: 2019101113393344800_ref43 article-title: Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder publication-title: Brain Research Bulletin doi: 10.1016/S0361-9230(01)00523-8 – volume: 16 start-page: 634 year: 2010 ident: 2019101113393344800_ref8 article-title: Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression publication-title: Molecular Psychiatry doi: 10.1038/mp.2010.44 – volume: 55 start-page: 712 year: 2007 ident: 2019101113393344800_ref38 article-title: Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action publication-title: Neuron doi: 10.1016/j.neuron.2007.07.041 – volume: 54 start-page: 208 year: 2003 ident: 2019101113393344800_ref66 article-title: Social and economic burden of mood disorders publication-title: Biological Psychiatry doi: 10.1016/S0006-3223(03)00420-7 – volume: 20 start-page: 565 year: 2007 ident: 2019101113393344800_ref60 article-title: 5-HT2C receptor agonists as an innovative approach for psychiatric disorders publication-title: Drug News and Perspectives doi: 10.1358/dnp.2007.20.9.1162244 – volume: 18 start-page: 391 year: 2007 ident: 2019101113393344800_ref62 article-title: The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior publication-title: Behavioural Pharmacology doi: 10.1097/FBP.0b013e3282ee2aa8 – volume: 105 start-page: 825 year: 2001 ident: 2019101113393344800_ref65 article-title: AMPA receptor trafficking and the control of synaptic transmission publication-title: Cell doi: 10.1016/S0092-8674(01)00406-8 – volume: 54 start-page: 129 year: 1996 ident: 2019101113393344800_ref22 article-title: Role of 5-HT in stress, anxiety, and depression publication-title: Pharmacology, Biochemistry, and Behavior doi: 10.1016/0091-3057(95)02135-3 – volume: 12 start-page: 1591 year: 2003 ident: 2019101113393344800_ref48 article-title: DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation publication-title: Human Molecular Genetics doi: 10.1093/hmg/ddg162 – volume: 69 start-page: 754 year: 2011 ident: 2019101113393344800_ref34 article-title: Glutamate N-methyl-d-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure publication-title: Biological Psychiatry doi: 10.1016/j.biopsych.2010.12.015 – volume: 108 start-page: 311 year: 2001 ident: 2019101113393344800_ref55 article-title: Brain monoamine receptors in a chronic unpredictable stress model in rats publication-title: Journal of Neural Transmission doi: 10.1007/s007020170077 – volume: 52 start-page: 90 year: 2005 ident: 2019101113393344800_ref79 article-title: Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS publication-title: Neuropsychobiology doi: 10.1159/000087097 – volume: 49 start-page: 4 year: 1988 ident: 2019101113393344800_ref10 article-title: Serotonin and its place in the pathogenesis of depression publication-title: Journal of Clinical Psychiatry – volume: 55 start-page: 225 year: 2004 ident: 2019101113393344800_ref37 article-title: Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia publication-title: Biological Psychiatry doi: 10.1016/j.biopsych.2003.09.017 – volume: 160 start-page: 1516 year: 2003 ident: 2019101113393344800_ref63 article-title: Untreated depression and hippocampal volume loss publication-title: American Journal of Psychiatry doi: 10.1176/appi.ajp.160.8.1516 – volume: 54 start-page: 597 year: 1997 ident: 2019101113393344800_ref15 article-title: A molecular and cellular theory of depression publication-title: Archives of General Psychiatry doi: 10.1001/archpsyc.1997.01830190015002 – volume: 63 start-page: 761 year: 2009 ident: 2019101113393344800_ref29 article-title: DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 publication-title: Neuron doi: 10.1016/j.neuron.2009.08.008 – volume: 262 start-page: 1 year: 1999 ident: 2019101113393344800_ref74 article-title: Role of 5-HT2A receptors in the stress-induced down-regulation of brain-derived neurotrophic factor expression in rat hippocampus publication-title: Neuroscience Letters doi: 10.1016/S0304-3940(99)00006-3 – volume: 4 start-page: 389 year: 1994 ident: 2019101113393344800_ref5 article-title: Synaptic plasticity: LTP and LTD publication-title: Current Opinion in Neurobiology doi: 10.1016/0959-4388(94)90101-5 – volume: 93 start-page: 3908 year: 1996 ident: 2019101113393344800_ref64 article-title: Hippocampal atrophy in recurrent major depression publication-title: Proceedings of the National Academy of Sciences USA doi: 10.1073/pnas.93.9.3908 – volume: 11 start-page: 239 year: 2009 ident: 2019101113393344800_ref14 article-title: Neuronal damage and protection in the pathophysiology and treatment of psychiatric illness: stress and depression publication-title: Dialogues in Clinical Neuroscience doi: 10.31887/DCNS.2009.11.3/rsduman – volume: 102 start-page: 361 year: 2001 ident: 2019101113393344800_ref17 article-title: 5-HT(7) receptors activate the mitogen activated protein kinase extracellular signal related kinase in cultured rat hippocampal neurons publication-title: Neuroscience doi: 10.1016/S0306-4522(00)00460-7 – volume: 64 start-page: 1465 year: 2003 ident: 2019101113393344800_ref23 article-title: The economic burden of depression in the United States: how did it change between 1990 and 2000? publication-title: Journal of Clinical Psychiatry doi: 10.4088/JCP.v64n1211 – volume: 62 start-page: 496 year: 2007 ident: 2019101113393344800_ref4 article-title: Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat publication-title: Biological Psychiatry doi: 10.1016/j.biopsych.2007.02.006 – volume: 23 start-page: 10841 year: 2003 ident: 2019101113393344800_ref52 article-title: Gene profile of electroconvulsive seizures: induction of neurotrophic and angiogenic factors publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.23-34-10841.2003 – volume-title: Diagnostic and Statistical Manual of Mental Health Disorders year: 1994 ident: 2019101113393344800_ref1a – volume: 99 start-page: 3182 year: 2002 ident: 2019101113393344800_ref71 article-title: Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac) publication-title: Proceedings of the National Academy of Sciences USA doi: 10.1073/pnas.052712799 – volume: 100 start-page: 9440 year: 2003 ident: 2019101113393344800_ref70 article-title: Statistical significance for genomewide studies publication-title: Proceedings of the National Academy of Sciences USA doi: 10.1073/pnas.1530509100 – volume: 71 start-page: 555 year: 2002 ident: 2019101113393344800_ref27 article-title: The medical benefit of 5-HT research publication-title: Pharmacology, Biochemistry, and Behavior doi: 10.1016/S0091-3057(01)00745-6 – volume: 371 start-page: 113 year: 1999 ident: 2019101113393344800_ref40 article-title: Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress publication-title: European Journal of Pharmacology doi: 10.1016/S0014-2999(99)00163-6 – volume: 1127 start-page: 108 year: 2007 ident: 2019101113393344800_ref39 article-title: Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder publication-title: Brain Research doi: 10.1016/j.brainres.2006.09.011 – volume: 37 start-page: 357 year: 2003 ident: 2019101113393344800_ref67 article-title: Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter publication-title: Journal of Psychiatric Research doi: 10.1016/S0022-3956(03)00050-5 – volume: 4 start-page: 110 year: 2004 ident: 2019101113393344800_ref58 article-title: Differential regulation of synaptic vesicle proteins by antidepressant drugs publication-title: Pharmacogenomics Journal doi: 10.1038/sj.tpj.6500229 – reference: 1393587 - Brain Res. 1992 Aug 21;588(2):341-5 – reference: 14645477 - J Neurosci. 2003 Nov 26;23(34):10841-51 – reference: 15531111 - Neurosci Lett. 2004 Nov 30;372(1-2):173-7 – reference: 15820716 - Biol Psychiatry. 2005 Apr 15;57(8):935-7 – reference: 14684431 - Ann N Y Acad Sci. 2003 Nov;1003:1-11 – reference: 11576760 - Brain Res Bull. 2001 Jul 15;55(5):631-40 – reference: 11888547 - Pharmacol Biochem Behav. 2002 Apr;71(4):555-68 – reference: 7919934 - Curr Opin Neurobiol. 1994 Jun;4(3):389-99 – reference: 8677218 - Psychiatr Clin North Am. 1996 Mar;19(1):29-39 – reference: 8604042 - J Neurosci. 1996 Mar 15;16(6):1982-9 – reference: 12969265 - J Neurochem. 2003 Oct;87(1):182-94 – reference: 16951582 - Neuroreport. 2006 Aug 21;17(12):1343-6 – reference: 14708000 - Pharmacogenomics J. 2004;4(2):110-3 – reference: 12113781 - Brain Res Brain Res Protoc. 2002 Jun;9(3):214-9 – reference: 17785179 - Neuron. 2007 Sep 6;55(5):712-25 – reference: 21292242 - Biol Psychiatry. 2011 Apr 15;69(8):754-61 – reference: 18825147 - Mol Psychiatry. 2010 May;15(5):501-11 – reference: 11870006 - Am J Psychiatry. 2002 Mar;159(3):419-29 – reference: 9616796 - Ann N Y Acad Sci. 1997 Dec 29;836:106-34 – reference: 12849929 - J Psychiatr Res. 2003 Sep-Oct;37(5):357-73 – reference: 18045159 - CNS Neurol Disord Drug Targets. 2007 Oct;6(5):311-20 – reference: 11439178 - Cell. 2001 Jun 29;105(7):825-8 – reference: 19877493 - Dialogues Clin Neurosci. 2009;11(3):239-55 – reference: 20059803 - Int J Neuropsychopharmacol. 2010 Oct;13(9):1207-18 – reference: 1831963 - Ann N Y Acad Sci. 1991;627:58-74 – reference: 17574216 - Biol Psychiatry. 2007 Dec 1;62(11):1310-6 – reference: 15522247 - Biol Psychiatry. 2004 Nov 1;56(9):640-50 – reference: 8717376 - Brain Res Mol Brain Res. 1996 Jan;35(1-2):349-53 – reference: 16037678 - Neuropsychobiology. 2005;52(2):90-110 – reference: 11166122 - Neuroscience. 2001;102(2):361-7 – reference: 8728550 - Pharmacol Biochem Behav. 1996 May;54(1):129-41 – reference: 19778506 - Neuron. 2009 Sep 24;63(6):761-73 – reference: 17762509 - Behav Pharmacol. 2007 Sep;18(5-6):391-418 – reference: 3045111 - J Clin Psychiatry. 1988 Aug;49 Suppl:4-11 – reference: 14744461 - Biol Psychiatry. 2004 Feb 1;55(3):217-24 – reference: 11786304 - Curr Opin Pharmacol. 2002 Feb;2(1):18-22 – reference: 19621857 - Am Fam Physician. 2009 Jul 15;80(2):167-72 – reference: 14744462 - Biol Psychiatry. 2004 Feb 1;55(3):225-33 – reference: 8827185 - Psychiatr Clin North Am. 1996 Jun;19(2):179-200 – reference: 17297636 - Psychopharmacology (Berl). 2007 Jun;192(2):159-70 – reference: 8504792 - Epilepsy Res. 1993 Mar;14(3):221-7 – reference: 9236543 - Arch Gen Psychiatry. 1997 Jul;54(7):597-606 – reference: 18992785 - Prog Neuropsychopharmacol Biol Psychiatry. 2009 Feb 1;33(1):70-5 – reference: 18639237 - Biol Psychiatry. 2008 Nov 15;64(10):863-70 – reference: 15220856 - CNS Spectr. 2002 Feb;7(2):140-2, 144-7 – reference: 9736659 - J Neurosci. 1998 Sep 15;18(18):7394-401 – reference: 17113057 - Brain Res. 2007 Jan 5;1127(1):108-18 – reference: 12706957 - Biol Psychiatry. 2003 Apr 15;53(8):707-42 – reference: 11588613 - Neuroreport. 2001 Sep 17;12(13):2971-4 – reference: 17451451 - Genes Brain Behav. 2007 Jul;6(5):491-6 – reference: 12813115 - JAMA. 2003 Jun 18;289(23):3095-105 – reference: 18176661 - Drug News Perspect. 2007 Nov;20(9):565-71 – reference: 12812986 - Hum Mol Genet. 2003 Jul 1;12(13):1591-608 – reference: 12691775 - Prog Neuropsychopharmacol Biol Psychiatry. 2003 May;27(3):411-7 – reference: 15118356 - Neuropsychobiology. 2004;49(4):189-95 – reference: 12140780 - Mol Psychiatry. 2002;7(6):571-8 – reference: 20386568 - Mol Psychiatry. 2011 Jun;16(6):634-46 – reference: 16983646 - Synapse. 2006 Dec 15;60(8):585-98 – reference: 16433010 - Therapie. 2005 Sep-Oct;60(5):441-60 – reference: 17585885 - Biol Psychiatry. 2007 Sep 1;62(5):496-504 – reference: 16522330 - Pharmacol Ther. 2006 May;110(2):135-370 – reference: 2017440 - Pharmacol Biochem Behav. 1991 Jan;38(1):125-30 – reference: 12883005 - Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5 – reference: 15618528 - Biostatistics. 2005 Jan;6(1):59-75 – reference: 15001809 - Neuromolecular Med. 2004;5(1):11-25 – reference: 17851537 - Neuropsychopharmacology. 2008 Jan;33(1):88-109 – reference: 14708030 - Mol Psychiatry. 2004 Jun;9(6):609-20, 544 – reference: 12629503 - Pharmacogenomics J. 2002;2(6):377-82 – reference: 17220535 - Mol Neurobiol. 2006 Oct;34(2):137-51 – reference: 2282447 - Brain Res Brain Res Rev. 1990 May-Aug;15(2):101-20 – reference: 8632988 - Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3908-13 – reference: 20953200 - Nat Med. 2010 Nov;16(11):1328-32 – reference: 19579172 - Curr Opin Investig Drugs. 2009 Jul;10(7):664-71 – reference: 18056259 - J Biol Chem. 2008 Feb 15;283(7):4155-64 – reference: 14728109 - J Clin Psychiatry. 2003 Dec;64(12):1465-75 – reference: 11880651 - Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3182-7 – reference: 11341483 - J Neural Transm (Vienna). 2001;108(3):311-9 – reference: 12893097 - Biol Psychiatry. 2003 Aug 1;54(3):208-15 – reference: 10076858 - Neurosci Lett. 1999 Feb 26;262(1):1-4 – reference: 12900317 - Am J Psychiatry. 2003 Aug;160(8):1516-8 – reference: 10357248 - Eur J Pharmacol. 1999 Apr 29;371(2-3):113-22 |
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| Snippet | Major depressive disorder (MDD) has been linked to changes in function and activity of the hippocampus, one of the central limbic regions involved in... Abstract Major depressive disorder (MDD) has been linked to changes in function and activity of the hippocampus, one of the central limbic regions involved in... |
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| Title | Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects |
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