Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects
Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolari...
Saved in:
| Published in | British journal of nutrition Vol. 99; no. 6; pp. 1301 - 1309 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge, UK
Cambridge University Press
01.06.2008
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolariciresinol diglucoside (SDG) from flaxseed extract to determine the effect on plasma lipids and fasting glucose levels. Significant treatment effects were achieved (P < 0·05 to < 0·001) for the decrease of total cholesterol (TC), LDL-cholesterol (LDL-C) and glucose concentrations, as well as their percentage decrease from baseline. At weeks 6 and 8 in the 600 mg SDG group, the decreases of TC and LDL-C concentrations were in the range from 22·0 to 24·38 % respectively (all P < 0·005 compared with placebo). For the 300 mg SDG group, only significant differences from baseline were observed for decreases of TC and LDL-C. A substantial effect on lowering concentrations of fasting plasma glucose was also noted in the 600 mg SDG group at weeks 6 and 8, especially in the subjects with baseline glucose concentrations ≥ 5·83 mmol/l (lowered 25·56 and 24·96 %; P = 0·015 and P = 0·012 compared with placebo, respectively). Plasma concentrations of secoisolariciresinol (SECO), enterodiol (ED) and enterolactone were all significantly raised in the groups supplemented with flaxseed lignan. The observed cholesterol-lowering values were correlated with the concentrations of plasma SECO and ED (r 0·128–0·302; P < 0·05 to < 0·001). In conclusion, dietary flaxseed lignan extract decreased plasma cholesterol and glucose concentrations in a dose-dependent manner. |
|---|---|
| AbstractList | Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolariciresinol diglucoside (SDG) from flaxseed extract to determine the effect on plasma lipids and fasting glucose levels. Significant treatment effects were achieved (P < 0.05 to < 0.001) for the decrease of total cholesterol (TC), LDL-cholesterol (LDL-C) and glucose concentrations, as well as their percentage decrease from baseline. At weeks 6 and 8 in the 600 mg SDG group, the decreases of TC and LDL-C concentrations were in the range from 22.0 to 24.38 % respectively (all P < 0.005 compared with placebo). For the 300 mg SDG group, only significant differences from baseline were observed for decreases of TC and LDL-C. A substantial effect on lowering concentrations of fasting plasma glucose was also noted in the 600 mg SDG group at weeks 6 and 8, especially in the subjects with baseline glucose concentrations > or = 5.83 mmol/l (lowered 25.56 and 24.96 %; P = 0.015 and P = 0.012 compared with placebo, respectively). Plasma concentrations of secoisolariciresinol (SECO), enterodiol (ED) and enterolactone were all significantly raised in the groups supplemented with flaxseed lignan. The observed cholesterol-lowering values were correlated with the concentrations of plasma SECO and ED (r 0.128-0.302; P < 0.05 to < 0.001). In conclusion, dietary flaxseed lignan extract decreased plasma cholesterol and glucose concentrations in a dose-dependent manner. Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolariciresinol diglucoside (SDG) from flaxseed extract to determine the effect on plasma lipids and fasting glucose levels. Significant treatment effects were achieved ( P < 0·05 to < 0·001) for the decrease of total cholesterol (TC), LDL-cholesterol (LDL-C) and glucose concentrations, as well as their percentage decrease from baseline. At weeks 6 and 8 in the 600 mg SDG group, the decreases of TC and LDL-C concentrations were in the range from 22·0 to 24·38 % respectively (all P < 0·005 compared with placebo). For the 300 mg SDG group, only significant differences from baseline were observed for decreases of TC and LDL-C. A substantial effect on lowering concentrations of fasting plasma glucose was also noted in the 600 mg SDG group at weeks 6 and 8, especially in the subjects with baseline glucose concentrations ≥ 5·83 mmol/l (lowered 25·56 and 24·96 %; P = 0·015 and P = 0·012 compared with placebo, respectively). Plasma concentrations of secoisolariciresinol (SECO), enterodiol (ED) and enterolactone were all significantly raised in the groups supplemented with flaxseed lignan. The observed cholesterol-lowering values were correlated with the concentrations of plasma SECO and ED ( r 0·128–0·302; P < 0·05 to < 0·001). In conclusion, dietary flaxseed lignan extract decreased plasma cholesterol and glucose concentrations in a dose-dependent manner. Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolariciresinol diglucoside (SDG) from flaxseed extract to determine the effect on plasma lipids and fasting glucose levels. Significant treatment effects were achieved (P < 0·05 to < 0·001) for the decrease of total cholesterol (TC), LDL-cholesterol (LDL-C) and glucose concentrations, as well as their percentage decrease from baseline. At weeks 6 and 8 in the 600 mg SDG group, the decreases of TC and LDL-C concentrations were in the range from 22·0 to 24·38 % respectively (all P < 0·005 compared with placebo). For the 300 mg SDG group, only significant differences from baseline were observed for decreases of TC and LDL-C. A substantial effect on lowering concentrations of fasting plasma glucose was also noted in the 600 mg SDG group at weeks 6 and 8, especially in the subjects with baseline glucose concentrations ≥ 5·83 mmol/l (lowered 25·56 and 24·96 %; P = 0·015 and P = 0·012 compared with placebo, respectively). Plasma concentrations of secoisolariciresinol (SECO), enterodiol (ED) and enterolactone were all significantly raised in the groups supplemented with flaxseed lignan. The observed cholesterol-lowering values were correlated with the concentrations of plasma SECO and ED (r 0·128–0·302; P < 0·05 to < 0·001). In conclusion, dietary flaxseed lignan extract decreased plasma cholesterol and glucose concentrations in a dose-dependent manner. Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolariciresinol diglucoside (SDG) from flaxseed extract to determine the effect on plasma lipids and fasting glucose levels. Significant treatment effects were achieved (P < 0.05 to < 0.001) for the decrease of total cholesterol (TC), LDL-cholesterol (LDL-C) and glucose concentrations, as well as their percentage decrease from baseline. At weeks 6 and 8 in the 600 mg SDG group, the decreases of TC and LDL-C concentrations were in the range from 22.0 to 24.38 % respectively (all P < 0.005 compared with placebo). For the 300 mg SDG group, only significant differences from baseline were observed for decreases of TC and LDL-C. A substantial effect on lowering concentrations of fasting plasma glucose was also noted in the 600 mg SDG group at weeks 6 and 8, especially in the subjects with baseline glucose concentrations > or = 5.83 mmol/l (lowered 25.56 and 24.96 %; P = 0.015 and P = 0.012 compared with placebo, respectively). Plasma concentrations of secoisolariciresinol (SECO), enterodiol (ED) and enterolactone were all significantly raised in the groups supplemented with flaxseed lignan. The observed cholesterol-lowering values were correlated with the concentrations of plasma SECO and ED (r 0.128-0.302; P < 0.05 to < 0.001). In conclusion, dietary flaxseed lignan extract decreased plasma cholesterol and glucose concentrations in a dose-dependent manner.Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolariciresinol diglucoside (SDG) from flaxseed extract to determine the effect on plasma lipids and fasting glucose levels. Significant treatment effects were achieved (P < 0.05 to < 0.001) for the decrease of total cholesterol (TC), LDL-cholesterol (LDL-C) and glucose concentrations, as well as their percentage decrease from baseline. At weeks 6 and 8 in the 600 mg SDG group, the decreases of TC and LDL-C concentrations were in the range from 22.0 to 24.38 % respectively (all P < 0.005 compared with placebo). For the 300 mg SDG group, only significant differences from baseline were observed for decreases of TC and LDL-C. A substantial effect on lowering concentrations of fasting plasma glucose was also noted in the 600 mg SDG group at weeks 6 and 8, especially in the subjects with baseline glucose concentrations > or = 5.83 mmol/l (lowered 25.56 and 24.96 %; P = 0.015 and P = 0.012 compared with placebo, respectively). Plasma concentrations of secoisolariciresinol (SECO), enterodiol (ED) and enterolactone were all significantly raised in the groups supplemented with flaxseed lignan. The observed cholesterol-lowering values were correlated with the concentrations of plasma SECO and ED (r 0.128-0.302; P < 0.05 to < 0.001). In conclusion, dietary flaxseed lignan extract decreased plasma cholesterol and glucose concentrations in a dose-dependent manner. Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolariciresinol diglucoside (SDG) from flaxseed extract to determine the effect on plasma lipids and fasting glucose levels. Significant treatment effects were achieved (P < 0·05 to < 0·001) for the decrease of total cholesterol (TC), LDL-cholesterol (LDL-C) and glucose concentrations, as well as their percentage decrease from baseline. At weeks 6 and 8 in the 600 mg SDG group, the decreases of TC and LDL-C concentrations were in the range from 22·0 to 24·38 % respectively (all P < 0·005 compared with placebo). For the 300 mg SDG group, only significant differences from baseline were observed for decreases of TC and LDL-C. A substantial effect on lowering concentrations of fasting plasma glucose was also noted in the 600 mg SDG group at weeks 6 and 8, especially in the subjects with baseline glucose concentrations >= 5·83 mmol/l (lowered 25·56 and 24·96 %; P = 0·015 and P = 0·012 compared with placebo, respectively). Plasma concentrations of secoisolariciresinol (SECO), enterodiol (ED) and enterolactone were all significantly raised in the groups supplemented with flaxseed lignan. The observed cholesterol-lowering values were correlated with the concentrations of plasma SECO and ED (r 0·128-0·302; P < 0·05 to < 0·001). In conclusion, dietary flaxseed lignan extract decreased plasma cholesterol and glucose concentrations in a dose-dependent manner. Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind, placebo-controlled study was conducted in fifty-five hypercholesterolaemic subjects, using treatments of 0 (placebo), 300 or 600 mg/d of dietary secoisolariciresinol diglucoside (SDG) from flaxseed extract to determine the effect on plasma lipids and fasting glucose levels. Significant treatment effects were achieved (P < 0·05 to < 0·001) for the decrease of total cholesterol (TC), LDL-cholesterol (LDL-C) and glucose concentrations, as well as their percentage decrease from baseline. At weeks 6 and 8 in the 600 mg SDG group, the decreases of TC and LDL-C concentrations were in the range from 22·0 to 24·38 % respectively (all P < 0·005 compared with placebo). For the 300 mg SDG group, only significant differences from baseline were observed for decreases of TC and LDL-C. A substantial effect on lowering concentrations of fasting plasma glucose was also noted in the 600 mg SDG group at weeks 6 and 8, especially in the subjects with baseline glucose concentrations [greater than or equal to] 5·83 mmol/l (lowered 25·56 and 24·96 %; P = 0·015 and P = 0·012 compared with placebo, respectively). Plasma concentrations of secoisolariciresinol (SECO), enterodiol (ED) and enterolactone were all significantly raised in the groups supplemented with flaxseed lignan. The observed cholesterol-lowering values were correlated with the concentrations of plasma SECO and ED (r 0·128-0·302; P < 0·05 to < 0·001). In conclusion, dietary flaxseed lignan extract decreased plasma cholesterol and glucose concentrations in a dose-dependent manner. [PUBLICATION ABSTRACT] |
| Author | Sun, Sam Z. Tian, Haimei Empie, Mark W. Zhang, Wei Wang, Xiaobing Liu, Yi Flickinger, Brent |
| Author_xml | – sequence: 1 givenname: Wei surname: Zhang fullname: Zhang, Wei organization: 1Tumor Hospital and Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China – sequence: 2 givenname: Xiaobing surname: Wang fullname: Wang, Xiaobing organization: 1Tumor Hospital and Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China – sequence: 3 givenname: Yi surname: Liu fullname: Liu, Yi organization: 1Tumor Hospital and Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China – sequence: 4 givenname: Haimei surname: Tian fullname: Tian, Haimei organization: 1Tumor Hospital and Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China – sequence: 5 givenname: Brent surname: Flickinger fullname: Flickinger, Brent organization: 2James R. Randall Research Center, Archer Daniels Midland Company, 1001 Brush College Road, Decatur, Illinois 62521, USA – sequence: 6 givenname: Mark W. surname: Empie fullname: Empie, Mark W. organization: 2James R. Randall Research Center, Archer Daniels Midland Company, 1001 Brush College Road, Decatur, Illinois 62521, USA – sequence: 7 givenname: Sam Z. surname: Sun fullname: Sun, Sam Z. email: sun@admworld.com organization: 2James R. Randall Research Center, Archer Daniels Midland Company, 1001 Brush College Road, Decatur, Illinois 62521, USA |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20316900$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18053310$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkktvEzEUhUeoiD7gB7ABCwl2A36M7ZllVWhAqnioVCytG4-dOjh2sGcg_fd4SAioCFhZ1v2Odc7xPa4OQgymqh4S_JxgIl9cYowlIQ3HspVENN2d6og0ktdUCHpQHU3jepofVsc5L8u1Jbi7Vx2SFnPGCD6qvr50ZoB0g6yHTTamR94tAgRkNkMCPSAfv5mU0dpDXgHS19GbPJgUPYLQo4UfdcwG6Ri0CUUxuBgycgFd36xN-g0Hs3Ia5XG-NHrI96u7Fnw2D3bnSXV1_urj2ev64t3szdnpRa0FpkNtbIuNNRZAWo454L7D1LbAGe1Y3zIhJNAWpijGsmbOTa8FB9tQy7gFyk6qZ9t31yl-GYsVtXJZG-8hmDhmJTpCBWfyv2DTYtbiri3gk1vgMo4plBCKEtbSrul4gR7toHG-Mr1aJ7cqJaufvRfg6Q6ArMHbBEG7vOcoZkR0eOLkltMp5pyMVdoNP0ouXTuvCFbTJqg_NqEoyS3l3sQ_NPVW48qfbfYCSJ-VkExyJWYfFD9_Tz_N3nI18Y-3vIWoYJFKgqtLigkri9ZJKaYi2M4FrObJ9Qvzq66_-_gOl9ndNw |
| CODEN | BJNUAV |
| CitedBy_id | crossref_primary_10_1080_10408398_2024_2371939 crossref_primary_10_1089_jmf_2019_0055 crossref_primary_10_1016_j_jand_2016_11_003 crossref_primary_10_1021_acs_jnatprod_1c00335 crossref_primary_10_1080_09637486_2022_2052820 crossref_primary_10_1080_10408398_2022_2072807 crossref_primary_10_1039_D3FO00019B crossref_primary_10_3390_antiox11020316 crossref_primary_10_1007_s11101_023_09909_5 crossref_primary_10_1016_j_foodres_2023_112499 crossref_primary_10_1155_2012_585170 crossref_primary_10_1590_S0102_86502012000800004 crossref_primary_10_1002_ptr_6640 crossref_primary_10_3390_molecules30061335 crossref_primary_10_4236_fns_2021_127050 crossref_primary_10_1007_s11883_008_0074_3 crossref_primary_10_1016_j_cpcardiol_2021_100931 crossref_primary_10_1016_j_tifs_2014_03_011 crossref_primary_10_1016_j_nutres_2010_06_004 crossref_primary_10_1016_j_phrs_2019_104622 crossref_primary_10_1111_j_1542_4758_2012_00754_x crossref_primary_10_2478_enr_2021_0020 crossref_primary_10_1016_j_foodres_2015_07_035 crossref_primary_10_1016_j_lfs_2009_06_018 crossref_primary_10_1021_acs_jafc_6b01381 crossref_primary_10_1038_s41598_023_40378_0 crossref_primary_10_1021_acs_jafc_4c06947 crossref_primary_10_52547_nsft_16_1_1 crossref_primary_10_1111_ijcp_14592 crossref_primary_10_1002_jsfa_11491 crossref_primary_10_1111_j_1753_4887_2009_00192_x crossref_primary_10_2196_resprot_6817 crossref_primary_10_1007_s00253_011_3338_8 crossref_primary_10_1080_01635581_2018_1421677 crossref_primary_10_1080_07315724_2010_10719819 crossref_primary_10_1007_s00394_015_0885_2 crossref_primary_10_1039_D0FO02297G crossref_primary_10_1208_s12249_017_0721_5 crossref_primary_10_1016_j_nutres_2013_02_012 crossref_primary_10_1080_10408398_2023_2280768 crossref_primary_10_3390_antiox9100982 crossref_primary_10_1111_j_1753_4887_2010_00319_x crossref_primary_10_2174_1573399814666180914094520 crossref_primary_10_1186_s40816_020_0150_y crossref_primary_10_1271_bbb_80393 crossref_primary_10_1039_C8FO00390D crossref_primary_10_1080_07315724_2017_1342213 crossref_primary_10_3389_fphar_2021_775789 crossref_primary_10_1002_14651858_CD008305_pub2 crossref_primary_10_1016_j_jff_2016_12_021 crossref_primary_10_1016_j_lwt_2019_108860 crossref_primary_10_1055_s_0040_1709129 crossref_primary_10_1186_1475_2891_10_44 crossref_primary_10_1016_j_foodres_2010_06_004 crossref_primary_10_1089_jmf_2009_0192 crossref_primary_10_1616_1476_2137_15817 crossref_primary_10_1002_jsfa_6482 crossref_primary_10_1016_j_obmed_2020_100311 crossref_primary_10_1016_j_jchromb_2012_10_030 crossref_primary_10_1080_07315724_2013_791147 crossref_primary_10_5402_2013_521067 crossref_primary_10_7762_cnr_2019_8_4_284 crossref_primary_10_1017_S0954422412000170 crossref_primary_10_1007_s10847_014_0411_9 crossref_primary_10_1111_1750_3841_13964 crossref_primary_10_1016_j_jff_2016_04_032 crossref_primary_10_1002_biof_1684 crossref_primary_10_1016_j_foodchem_2010_11_169 crossref_primary_10_1002_jsfa_7705 crossref_primary_10_1002_mnfr_201500773 crossref_primary_10_1017_S0007114509992753 crossref_primary_10_1080_10408398_2022_2148627 crossref_primary_10_1111_j_1574_6941_2010_00863_x crossref_primary_10_1111_and_12489 crossref_primary_10_1186_s12937_015_0059_3 crossref_primary_10_1002_ptr_5635 crossref_primary_10_1007_s12010_021_03568_y crossref_primary_10_1017_S0007114508207488 crossref_primary_10_1016_j_procbio_2011_05_006 crossref_primary_10_1186_s12974_018_1065_0 crossref_primary_10_1139_H09_087 crossref_primary_10_1016_j_nut_2014_05_002 crossref_primary_10_1111_nure_12085 crossref_primary_10_1186_s12986_021_00619_3 crossref_primary_10_1016_j_fct_2009_11_051 crossref_primary_10_1016_j_chroma_2019_04_072 crossref_primary_10_1016_j_procbio_2015_10_012 crossref_primary_10_3109_09637486_2014_893283 crossref_primary_10_1039_D0FO00124D crossref_primary_10_1016_S0828_282X_10_70455_4 crossref_primary_10_2174_1386207323666200521121708 crossref_primary_10_1039_C1FO10166H crossref_primary_10_22424_jmsb_2018_36_2_81 crossref_primary_10_1080_19476337_2014_953209 crossref_primary_10_1021_np4004905 crossref_primary_10_3390_ph12020068 crossref_primary_10_1007_s00125_019_4854_9 crossref_primary_10_1007_s10787_021_00902_y crossref_primary_10_3390_nutraceuticals3010005 crossref_primary_10_1080_10408398_2020_1784840 crossref_primary_10_1016_j_fct_2012_04_040 crossref_primary_10_3390_molecules26030767 crossref_primary_10_1016_j_bcab_2017_11_017 crossref_primary_10_3945_ajcn_2009_27469 crossref_primary_10_1152_ajpheart_00400_2017 crossref_primary_10_3390_microorganisms10112169 crossref_primary_10_1007_s11886_020_01397_9 crossref_primary_10_1097_FJC_0b013e3181af04e5 crossref_primary_10_1177_1934578X1701200139 crossref_primary_10_3164_jcbn_23_122 crossref_primary_10_3389_fgene_2018_00641 crossref_primary_10_1016_j_bbagen_2018_03_003 crossref_primary_10_1093_nutrit_nux052 crossref_primary_10_1002_mnfr_201500900 crossref_primary_10_1080_09291016_2019_1600265 crossref_primary_10_1093_ajcn_nqaa026 crossref_primary_10_1021_acs_jnatprod_1c00549 crossref_primary_10_3109_13880209_2013_766220 crossref_primary_10_1139_H08_142 crossref_primary_10_1017_S0007114516000581 crossref_primary_10_1016_j_carres_2023_108855 crossref_primary_10_1016_j_jff_2015_06_042 crossref_primary_10_3390_antiox10050784 crossref_primary_10_1002_jsfa_13412 crossref_primary_10_1016_j_phanu_2023_100366 crossref_primary_10_1016_j_jff_2014_06_020 |
| Cites_doi | 10.1210/jc.2004-1148 10.1079/BJN19930046 10.1093/ajcn/61.1.62 10.1016/S0090-4295(01)01014-7 10.1093/jn/136.1.112 10.1677/joe.0.1420251 10.1053/j.ajkd.2005.08.031 10.1079/BJN2002601 10.1016/j.atherosclerosis.2003.12.032 10.1007/s11745-003-1185-7 10.1016/j.metabol.2005.02.010 10.1161/01.ATV.17.6.1163 10.1161/01.CIR.99.10.1355 10.1194/jlr.M400448-JLR200 10.1097/00001721-200312000-00003 10.1080/07315724.2003.10719336 10.1093/ajcn/69.3.549 10.1017/S0007114500002452 10.1016/j.atherosclerosis.2004.11.012 10.1177/107424840501000103 10.1093/jn/134.5.1197 10.1016/S0005-2760(97)00040-4 10.1093/ajcn/73.6.1094 10.1093/jn/131.10.3168 10.1111/j.1753-4887.2004.tb00002.x 10.1210/jcem.87.4.8374 10.1016/S0021-9150(97)06110-8 10.1016/S0301-2115(98)00281-4 10.1080/07315724.2003.10719289 10.1016/S0944-7113(97)80063-3 10.1093/ajcn/65.5.1645S 10.1016/j.urology.2003.12.010 10.1093/jn/134.10.2691 10.1016/S0021-9673(03)01136-1 10.1016/S0021-9150(97)00239-6 10.1016/S0140-6736(99)05031-X |
| ContentType | Journal Article |
| Copyright | Copyright © The Authors 2007 2008 INIST-CNRS The Authors |
| Copyright_xml | – notice: Copyright © The Authors 2007 – notice: 2008 INIST-CNRS – notice: The Authors |
| DBID | FBQ BSCLL AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 3V. 7QP 7RV 7T5 7X2 7X7 7XB 88E 8C1 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AEUYN AFKRA AN0 ATCPS AZQEC BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB0 M0K M0S M1P M2O MBDVC NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI Q9U 7S9 L.6 7X8 |
| DOI | 10.1017/S0007114507871649 |
| DatabaseName | AGRIS Istex CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Nursing & Allied Health Database Immunology Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Public Health Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland British Nursing Database Agricultural & Environmental Science Collection ProQuest Central Essentials ProQuest Central Natural Science Collection ProQuest One ProQuest Central Korea Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Agricultural Science Database ProQuest Health & Medical Collection PML(ProQuest Medical Library) Research Library Research Library (Corporate) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central Basic AGRICOLA AGRICOLA - Academic MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Central ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health ProQuest Central Basic ProQuest One Academic Eastern Edition Agricultural Science Collection British Nursing Index with Full Text ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) AGRICOLA AGRICOLA - Academic MEDLINE - Academic |
| DatabaseTitleList | MEDLINE CrossRef MEDLINE - Academic Agricultural Science Database AGRICOLA |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database – sequence: 4 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Diet & Clinical Nutrition |
| DocumentTitleAlternate | W. Zhang et al. Lignans lower plasma cholesterol and glucose |
| EISSN | 1475-2662 |
| EndPage | 1309 |
| ExternalDocumentID | 1801538141 18053310 20316900 10_1017_S0007114507871649 ark_67375_6GQ_5FP2WGN5_9 US201300897765 |
| Genre | Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -1D -1F -2P -2V -E. -~6 -~N -~X .55 .FH .GJ 09C 09E 0E1 0R~ 23N 2WC 354 3EH 3O- 3V. 4.4 53G 5GY 5RE 5VS 6J9 6PF 6~7 74X 74Y 7RV 7X2 7X7 7~V 88E 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 9M5 AAAZR AABES AABWE AACJH AAEED AAFWJ AAGFV AAIKC AAKTX AAMNQ AAMNW AANRG AARAB AASVR AATID AAUIS AAUKB AAWTL AAYJJ AAZAQ ABBJB ABBXD ABBZL ABFBI ABGDZ ABJNI ABKKG ABKMT ABMWE ABMYL ABQTM ABROB ABUWG ABVFV ABWCF ABXAU ABZCX ABZUI ACBEK ACBMC ACCHT ACETC ACGFS ACIMK ACMRT ACPRK ACQFJ ACREK ACUIJ ACUYZ ACWGA ACYZP ACZBM ACZUX ACZWT ADAZD ADBBV ADDNB ADFEC ADFRT ADGEJ ADKIL ADOCW ADOVH ADOVT ADVJH AEBAK AEBPU AEHGV AEMTW AENCP AENEX AENGE AEPLO AEYHU AEYYC AFFNX AFFUJ AFKQG AFKRA AFLOS AFLVW AFOSN AFRAH AFRIC AFUTZ AGABE AGJUD AGLWM AGOOT AHIPN AHLTW AHMBA AHQXX AHRGI AI. AIGNW AIHIV AIOIP AISIE AJ7 AJCYY AJPFC AJQAS AKZCZ ALEEW ALMA_UNASSIGNED_HOLDINGS ALWZO AN0 ANPSP AQJOH AQVPL ARABE ARZZG ATCPS ATUCA AUXHV AYIQA AZGZS AZQEC BAWUL BBLKV BCGOX BENPR BESQT BGHMG BHPHI BJBOZ BKEYQ BLZWO BMAJL BNQBC BPHCQ BQFHP BRIRG BVXVI C0O C1A CAG CBIIA CCPQU CCQAD CCUQV CDIZJ CFAFE CFBFF CGQII CHEAL CJCSC COF CS3 DIK DOHLZ DU5 DWQXO E3Z EBS EGQIC EJD EX3 F5P FYUFA GNUQQ GUQSH HCIFZ HG- HH5 HMCUK HST HZ~ I.6 I.7 I.9 IH6 IOEEP IOO IS6 I~P J36 J38 J3A JHPGK JKPOH JQKCU JVRFK KAFGG KC5 KCGVB KFECR L7B L98 LHUNA LW7 M-V M0K M1P M2O M7~ M8. NAPCQ NIKVX NMFBF NZEOI O9- OHT OK1 OVD P6G PCD PQQKQ PROAC PSQYO Q2X RAMDC RCA RIG ROL RR0 S6- S6U SAAAG SJN SY4 T9M TEORI TR2 UAP UCJ UKHRP UT1 UU6 VH1 WFFJZ WH7 WOW WQ3 WXU WXY WYP X7M Y6R ZA5 ZCG ZDLDU ZGI ZJOSE ZMEZD ZXP ZYDXJ ~KM ~V1 AEQTP FBQ AAHBH AAKNA AATMM ABVKB ABVZP ABXHF ACDLN ACEJA ACRPL ADNMO AEMFK AEUYN AFZFC AGQPQ AKMAY ANOYL BSCLL PHGZM PHGZT PJZUB PPXIY PUEGO AAYXX ABHFL ACOZI CITATION IQODW CGR CUY CVF ECM EIF NPM 7QP 7T5 7XB 8FK H94 K9. MBDVC PKEHL PQEST PQUKI Q9U 7S9 L.6 7X8 |
| ID | FETCH-LOGICAL-c602t-ef80efefaa7f505a0d902f8a53293d83667a28a3310ef34b5edc65af42f35fa23 |
| IEDL.DBID | 7X7 |
| ISSN | 0007-1145 1475-2662 |
| IngestDate | Fri Jul 11 13:41:43 EDT 2025 Sun Aug 24 04:14:11 EDT 2025 Sat Aug 23 12:32:12 EDT 2025 Mon Jul 21 05:53:02 EDT 2025 Mon Jul 21 09:13:29 EDT 2025 Tue Jul 01 03:49:54 EDT 2025 Thu Apr 24 23:10:57 EDT 2025 Sun Aug 31 06:48:17 EDT 2025 Wed Dec 27 19:05:03 EST 2023 Wed Mar 13 05:42:27 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | Secoisolariciresinol diglucoside Glucose Cholesterol Flaxseed lignans Human Vertebrata Mammalia Lipids Lignan Extract Concentration Flaxseed lignans: Secoisolariciresinol diglucoside: Cholesterol: Glucose Blood plasma |
| Language | English |
| License | https://www.cambridge.org/core/terms CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c602t-ef80efefaa7f505a0d902f8a53293d83667a28a3310ef34b5edc65af42f35fa23 |
| Notes | ArticleID:87164 istex:5460F7176D214D0F873BBF129C26FF4212EAF99E Abbreviations: ED, enterodiol; EL, enterolactone; HDL-C, HDL-cholesterol; LDL-C, LDL-cholesterol; SDG, secoisolariciresinol diglucoside; SECO, secoisolariciresinol; TC, total cholesterol PII:S0007114507871649 ark:/67375/6GQ-5FP2WGN5-9 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://www.cambridge.org/core/services/aop-cambridge-core/content/view/EBD7101B3AD73A68DDDA08D670FF996C/S0007114507871649a.pdf/div-class-title-dietary-flaxseed-lignan-extract-lowers-plasma-cholesterol-and-glucose-concentrations-in-hypercholesterolaemic-subjects-div.pdf |
| PMID | 18053310 |
| PQID | 213829495 |
| PQPubID | 5629 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_69126537 proquest_miscellaneous_48038098 proquest_journals_213829495 pubmed_primary_18053310 pascalfrancis_primary_20316900 crossref_citationtrail_10_1017_S0007114507871649 crossref_primary_10_1017_S0007114507871649 istex_primary_ark_67375_6GQ_5FP2WGN5_9 fao_agris_US201300897765 cambridge_journals_10_1017_S0007114507871649 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2008-06-01 |
| PublicationDateYYYYMMDD | 2008-06-01 |
| PublicationDate_xml | – month: 06 year: 2008 text: 2008-06-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Cambridge, UK |
| PublicationPlace_xml | – name: Cambridge, UK – name: Wallingford – name: England – name: Cambridge |
| PublicationTitle | British journal of nutrition |
| PublicationTitleAlternate | Br J Nutr |
| PublicationYear | 2008 |
| Publisher | Cambridge University Press |
| Publisher_xml | – name: Cambridge University Press |
| References | S0007114507871649_ref10 S0007114507871649_ref32 S0007114507871649_ref11 Mazur (S0007114507871649_ref37) 2000; 83 S0007114507871649_ref33 S0007114507871649_ref30 S0007114507871649_ref31 S0007114507871649_ref25 S0007114507871649_ref26 Juntunen (S0007114507871649_ref38) 2000; 84 S0007114507871649_ref23 S0007114507871649_ref45 Pietinen (S0007114507871649_ref40) 2001; 10 S0007114507871649_ref24 S0007114507871649_ref46 S0007114507871649_ref29 S0007114507871649_ref27 S0007114507871649_ref28 Duan (S0007114507871649_ref15) 2003 S0007114507871649_ref2 Hutchins (S0007114507871649_ref7) 2003 S0007114507871649_ref5 Du (S0007114507871649_ref18) 2006; 27 S0007114507871649_ref6 S0007114507871649_ref3 Stavro (S0007114507871649_ref4) 2003 Cunnane (S0007114507871649_ref16) 2003 S0007114507871649_ref9 Lemay (S0007114507871649_ref34) 2002; 100 S0007114507871649_ref8 S0007114507871649_ref43 S0007114507871649_ref21 S0007114507871649_ref44 S0007114507871649_ref22 S0007114507871649_ref41 S0007114507871649_ref42 S0007114507871649_ref20 S0007114507871649_ref14 S0007114507871649_ref36 S0007114507871649_ref12 S0007114507871649_ref35 S0007114507871649_ref13 Vaisey-Genser (S0007114507871649_ref1) 2003 S0007114507871649_ref19 S0007114507871649_ref17 S0007114507871649_ref39 |
| References_xml | – ident: S0007114507871649_ref25 doi: 10.1210/jc.2004-1148 – ident: S0007114507871649_ref35 doi: 10.1079/BJN19930046 – ident: S0007114507871649_ref33 doi: 10.1093/ajcn/61.1.62 – ident: S0007114507871649_ref23 doi: 10.1016/S0090-4295(01)01014-7 – ident: S0007114507871649_ref6 – ident: S0007114507871649_ref26 doi: 10.1093/jn/136.1.112 – ident: S0007114507871649_ref46 doi: 10.1677/joe.0.1420251 – ident: S0007114507871649_ref27 doi: 10.1053/j.ajkd.2005.08.031 – ident: S0007114507871649_ref42 doi: 10.1079/BJN2002601 – ident: S0007114507871649_ref13 doi: 10.1016/j.atherosclerosis.2003.12.032 – ident: S0007114507871649_ref11 doi: 10.1007/s11745-003-1185-7 – ident: S0007114507871649_ref20 doi: 10.1016/j.metabol.2005.02.010 – start-page: 1 volume-title: Flaxseed in Human Nutrition year: 2003 ident: S0007114507871649_ref15 – start-page: 1 volume-title: Flax year: 2003 ident: S0007114507871649_ref1 – ident: S0007114507871649_ref32 doi: 10.1161/01.ATV.17.6.1163 – ident: S0007114507871649_ref9 doi: 10.1161/01.CIR.99.10.1355 – ident: S0007114507871649_ref21 doi: 10.1194/jlr.M400448-JLR200 – ident: S0007114507871649_ref14 doi: 10.1097/00001721-200312000-00003 – ident: S0007114507871649_ref28 doi: 10.1080/07315724.2003.10719336 – ident: S0007114507871649_ref45 doi: 10.1093/ajcn/69.3.549 – volume: 84 start-page: 839 year: 2000 ident: S0007114507871649_ref38 article-title: Consumption of wholemeal rye bread increases serum concentrations and urinary excretion of enterolactone compared with consumption of white wheat bread in healthy Finnish men and women publication-title: Br J Nutr doi: 10.1017/S0007114500002452 – ident: S0007114507871649_ref8 doi: 10.1016/j.atherosclerosis.2004.11.012 – ident: S0007114507871649_ref24 doi: 10.1177/107424840501000103 – ident: S0007114507871649_ref44 doi: 10.1093/jn/134.5.1197 – volume: 27 start-page: 168 year: 2006 ident: S0007114507871649_ref18 article-title: Determination of secoisolariciresonol diglucoside, secoisolariciresonol, enterolactone and enterodiol in serum by LC/MS/MS publication-title: J Chin Mass Spectrom Soc – volume: 83 start-page: 381 year: 2000 ident: S0007114507871649_ref37 article-title: Phyto-oestrogen content of berries, and plasma concentrations and urinary excretion of enterolactone after a single strawberry-meal in human subjects publication-title: Br J Nutr – ident: S0007114507871649_ref31 doi: 10.1016/S0005-2760(97)00040-4 – ident: S0007114507871649_ref39 doi: 10.1093/ajcn/73.6.1094 – volume: 100 start-page: 495 year: 2002 ident: S0007114507871649_ref34 article-title: Flaxseed dietary supplement versus hormone replacement therapy in hypercholesterolemic menopausal women publication-title: Obstet Gynecol – ident: S0007114507871649_ref41 doi: 10.1093/jn/131.10.3168 – start-page: 63 volume-title: Flaxseed in Human Nutrition year: 2003 ident: S0007114507871649_ref16 – start-page: 288 volume-title: Flaxseed in Human Nutrition year: 2003 ident: S0007114507871649_ref4 – ident: S0007114507871649_ref2 doi: 10.1111/j.1753-4887.2004.tb00002.x – ident: S0007114507871649_ref30 doi: 10.1210/jcem.87.4.8374 – start-page: 127 volume-title: Flaxseed in Human Nutrition year: 2003 ident: S0007114507871649_ref7 – ident: S0007114507871649_ref12 doi: 10.1016/S0021-9150(97)06110-8 – ident: S0007114507871649_ref19 doi: 10.1016/S0301-2115(98)00281-4 – ident: S0007114507871649_ref10 doi: 10.1080/07315724.2003.10719289 – ident: S0007114507871649_ref3 doi: 10.1016/S0944-7113(97)80063-3 – volume: 10 start-page: 339 year: 2001 ident: S0007114507871649_ref40 article-title: Serum enterolactone and risk of breast cancer: a case-control study in eastern Finland publication-title: Cancer Epidemiol Biomarkers Prev – ident: S0007114507871649_ref17 doi: 10.1093/ajcn/65.5.1645S – ident: S0007114507871649_ref22 doi: 10.1016/j.urology.2003.12.010 – ident: S0007114507871649_ref43 doi: 10.1093/jn/134.10.2691 – ident: S0007114507871649_ref5 doi: 10.1016/S0021-9673(03)01136-1 – ident: S0007114507871649_ref29 doi: 10.1016/S0021-9150(97)00239-6 – ident: S0007114507871649_ref36 doi: 10.1016/S0140-6736(99)05031-X |
| SSID | ssj0008109 |
| Score | 2.3320305 |
| Snippet | Lignans, derived from flaxseed, are phyto-oestrogens being increasingly studied for their health benefits. An 8-week, randomised, double-blind,... |
| SourceID | proquest pubmed pascalfrancis crossref istex fao cambridge |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1301 |
| SubjectTerms | administration & dosage Adult adults Alanine Transaminase Alanine Transaminase - blood analysis Biological and medical sciences blood blood glucose Blood Glucose - analysis Butylene Glycols Butylene Glycols - administration & dosage Cholesterol Cholesterol - blood Cholesterol, HDL Cholesterol, HDL - blood Cholesterol, LDL Cholesterol, LDL - blood Creatinine Creatinine - blood diet therapy Dietary Fiber Dietary Fiber - administration & dosage dietary nutrient sources dose response Double-Blind Method enterodiol enterolactone Feeding. Feeding behavior Female Flax Flaxseed lignans Fundamental and applied biological sciences. Psychology gamma-Glutamyltransferase gamma-Glutamyltransferase - blood Genetic diversity Glucose Glucosides Glucosides - administration & dosage Humans hypercholesterolemia Hypercholesterolemia - blood Hypercholesterolemia - diet therapy lignans Linear Models linseed Lipids Male Middle Aged Nitrogen Nitrogen - blood Nutrition nutritional intervention plant estrogens Plant Extracts Plant Extracts - administration & dosage Plasma Secoisolariciresinol diglucoside Studies Triglycerides Triglycerides - blood Urea Urea - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| Title | Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects |
| URI | https://www.cambridge.org/core/product/identifier/S0007114507871649/type/journal_article https://api.istex.fr/ark:/67375/6GQ-5FP2WGN5-9/fulltext.pdf https://www.ncbi.nlm.nih.gov/pubmed/18053310 https://www.proquest.com/docview/213829495 https://www.proquest.com/docview/48038098 https://www.proquest.com/docview/69126537 |
| Volume | 99 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3Nb9MwFLfYduGC-F4YFB_QDogIx24c54RgrJuQqMZHRW_RS2JvFSEtTYvGf897iZttQuulh8ROlfh9_J793u8x9gqUBp0aGxbo20PUxJJUyoVUdJ1HppCFpQLnz2N9Ohl-msZTn5vT-LTKjU1sDXU5L2iP_K0ksrwU4fy7xe-QmkbR4arvoLHD9oi5jDK6kmkfb6Gz8xkexIMYDePNoWbLGE2-Fa-hh6SIIb1OrXDDRe04mCNwpW9-SYmT0OC3c13Ti9tRaeudRvfZPQ8r-ftODh6wO7Z-yIKPM7vih9xzf1Z8vKHef8T-0D1Y_uWugssGXRivZuc11ByNNRVO8aptn8YXiK5_AScj2XIqzCsOdcl9pjsvqOqx9tS7DZ_V_AID2-W14UDZ97xZ57Th0zxmk9Hx96PT0PdgCAst5Cq0zgjrrANIHIIlEGUqpDMQK8QJpVFaJyANKESJ1qlhHtuy0DG4oXQqdiDVE7Zbz2u7z3guAFSuVEn1uKYsc5HoAhyGsRiypDYK2Jt-CTKvSU3WZaEl2X8rFjCxWaWs8Hzm1Faj2jbldT9l0ZF5bBu8j0ufwTka22zyTdIRrzAIl3UcsMNWHvqHwPInJcglcaZPvmTx6Ez-OBnHGT5jcENg-gkSbalOhQjYwUaCrl65F_WAvezvotbTUQ7Udr5usqERyojU3D5Cp5HUsUoC9rQTzKs3NlR_HYlnW__7gN3tUmNow-k5210t1_YF4q9VPmi1DH_NUTRgex-Ox2df_wEw1irk |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbK9gAXxLuh0PoAPSAiHDtxnANCQLvd0nZVoKv2FpzELitCdtnsQvuj-I_M5NVWqL31urGziubxzdgz3xDyQgupZaSMmwK2u2CJGZqUdbHpOvFUylODDc77QzkY-Z-Og-Ml8rfthcGyytYnVo46m6R4Rv6GI1leBOH8u-kvF4dG4eVqO0Gj1opdc_YHMrby7c4miPcl5_2tw48Dtxkq4KaS8blrrGLGGqt1aAH9Ncsixq3SgQDgy5SQMtRcaQFhj7HCTwKTpTLQ1udWBFYjzwF4_GVfQCbTI8sftoYHXzrXr7ympgSZFz0_aK9RK45qRHP4DTAZc5ToIpnDJVC8ZfUEQmWU8imWauoSpGXrMRtXx8EVHvbvkbtNIEvf15p3nyyZ4gFxNsdmTjdowzaa02FL9v-Q_MZnenZGba5PSwBNmo9PCl1QgAds1aJ5NbCNTiGe_6kpuuWKxWGSU11ktKmtpyn2WRYN2W9JxwX9Dqn07MJyjfX-tFwkeMRUPiKjGxHQY9IrJoVZITRhWotEiAw7gFWWJSyUqbaQOEOSFBnPIa87EcSN7ZZxXfcWxv9JzCGslVKcNgzqOMgjv27Lq27LtKYPuW7xCog-1ifg3uPRV46XykxBgC4Dh2xU-tC9RM9-YEleGMRy-3Mc9A_40fYwiOEda5cUptvAwXvLiDGHrLYadP7JnXE5ZL17Cn4GL490YSaLMvYVE4pF6uoVMvK4DETokCe1Yp5_scKOb489vfa_18ntweH-Xry3M9xdJXfqwhw87npGevPZwjyH6G-erDU2R8m3mzbzf8s7Z5A |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKkRAXxLuh0PoAPSCiOvbacQ4IIZZtS2FVBCv2ljqJXVaE7LLZhfan8e-YyautUPfWa_yIknnbM98Q8twIZVSkrZ-CbfdBEjMUKedj0XUS6JSnFgucPw3V_qj3YSzHa-RvWwuDaZWtTqwUdTZN8Yx8lyNYXgTu_K5rsiKO-oM3s18-NpDCi9a2m0bNIYf27A9Eb-Xrgz6Q-gXng_df3-37TYMBP1WML3zrNLPOOmNCB56AYVnEuNNGCjCCmRZKhYZrI8AFsk70EmmzVEnjetwJ6QxiHoD2vxkKGaCIheMu1gND22SXIAZj0JPthWqFVo12HZ6BdcZoJboI63DJPN5wZgpOM9L7FJM2TQl0c3XDjas94soyDu6SO41LS9_WPHiPrNniPvH6E7ugO7TBHc3psIX9f0B-45iZn1GXm9MSzCfNJyeFKSj8bizaonnVuo3OwLP_aSgq6ArPYZpTU2S0ybKnKVZcFg3sb0knBf0OQfX8wnSDmf-0XCZ42FQ-JKNrIc8jsl5MC7tBaMKMEYkQGdYC6yxLWKhS4yCEhnApsoFHXnUkiBspLuM6Ay6M_6OYR1hLpThtsNSxpUe-asnLbsmsBhJZNXkDSB-bE1D08egLx-tlpsFVV9IjOxU_dJuY-Q9MzgtlrPY-x3JwxL_tDWUMe2xdYphuAQc9riLGPLLZctD5J3di5pHtbhQ0Dl4jmcJOl2Xc00xoFumrZ6go4EqK0COPa8Y8_2KNtd8Be7Ly3dvkFgh3_PFgeLhJbtcZOnju9ZSsL-ZL-wzcwEWyVQkcJcfXLeH_ALu7amA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Dietary+flaxseed+lignan+extract+lowers+plasma+cholesterol+and+glucose+concentrations+in+hypercholesterolaemic+subjects&rft.jtitle=British+journal+of+nutrition&rft.au=Zhang%2C+Wei&rft.au=Wang%2C+Xiaobing&rft.au=Liu%2C+Yi&rft.au=Tian%2C+Haimei&rft.date=2008-06-01&rft.pub=Cambridge+University+Press&rft.issn=0007-1145&rft.eissn=1475-2662&rft.volume=99&rft.issue=6&rft.spage=1301&rft.epage=1309&rft_id=info:doi/10.1017%2FS0007114507871649&rft_id=info%3Apmid%2F18053310&rft.externalDocID=10_1017_S0007114507871649 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0007-1145&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0007-1145&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0007-1145&client=summon |