Do skeletal-related events predict overall survival in men with metastatic castration-resistant prostate cancer?

• Published in: Prostate cancer and prostatic diseases Vol. 19; no. 4; pp. 380 - 384
• Main Authors: Howard, L E, De Hoedt, A M, Aronson, W J, Kane, C J, Amling, C L, Cooperberg, M R, Terris, M K, Divers, C H, Valderrama, A, Freedland, S J
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.12.2016
• Subjects: Aged; Aged, 80 and over; Biopsy; Bone and Bones - pathology; Bone cancer; Bone Neoplasms - mortality; Bone Neoplasms - pathology; Bone Neoplasms - secondary; Bone surgery; Bone tumors; California; Cancer metastasis; Cancer therapies; Castration; Cohort Studies; Complications and side effects; Compression; Confidence intervals; Data collection; Denosumab; Dependent variables; Deprivation; Development and progression; Fractures, Spontaneous - mortality; Fractures, Spontaneous - pathology; Health aspects; Health services; Humans; Male; Medical records; Metastases; Metastasis; Mortality; Pain; Patient outcomes; Prognosis; Proportional Hazards Models; Prostate cancer; Prostatic Neoplasms, Castration-Resistant - mortality; Prostatic Neoplasms, Castration-Resistant - pathology; Quality of life; Radiation; Risk analysis; Risk Factors; Secondary analysis; Spinal cord; Spinal Cord Compression - mortality; Spinal Cord Compression - pathology; Survival; Time dependence; Zoledronic acid; California

Skeletal-related events (SREs) including pathologic fracture, spinal cord compression, radiation to bone and surgery to bone, are common in men with bone metastatic castration-resistant prostate cancer (mCRPC). Men with mCRPC are at high risk of death. Whether SREs predict mortality is unclear. We t...