Clinical, laboratory, and genetic risk factors for thrombosis in sickle cell disease

• Published in: Blood advances Vol. 4; no. 9; pp. 1978 - 1986
• Main Authors: Srisuwananukorn, Andrew, Raslan, Rasha, Zhang, Xu, Shah, Binal N., Han, Jin, Gowhari, Michel, Molokie, Robert E., Gordeuk, Victor R., Saraf, Santosh L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.05.2020; American Society of Hematology
• Subjects: Adult; Aged; Anemia, Sickle Cell - complications; Anemia, Sickle Cell - epidemiology; Anemia, Sickle Cell - genetics; Child; Humans; Laboratories; Red Cells, Iron, and Erythropoiesis; Retrospective Studies; Risk Factors; Thrombosis - etiology; Thrombosis - genetics

Sickle cell disease (SCD) patients are at a four- to 100-fold increased risk for thrombosis compared with the general population, although the mechanisms and risk factors are not clear. We investigated the incidence and predictors for thrombosis in a retrospective, longitudinal cohort of 1193 pediat...