NGF and BDNF expression in mouse DRG after spared nerve injury
[Display omitted] •Several studies have highlighted the important contribution of the DRG in a non-injured nerve.•We showed that a neurotrophin NGF was downregulated in intact DRG neurons after spared nerve injury.•Downregulation of NGF in intact DRG neurons may contribute to the neuropathic pain. N...
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| Published in | Neuroscience letters Vol. 686; pp. 67 - 73 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier B.V
01.11.2018
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| Abstract | [Display omitted]
•Several studies have highlighted the important contribution of the DRG in a non-injured nerve.•We showed that a neurotrophin NGF was downregulated in intact DRG neurons after spared nerve injury.•Downregulation of NGF in intact DRG neurons may contribute to the neuropathic pain.
Neuropathic pain is initiated by a primary lesion in the peripheral nervous system and spoils quality of life. Neurotrophins play important roles in the development and transmission of neuropathic pain. There are conflicting reports that the dorsal root ganglion (DRG) in an injured nerve contribute to neuropathic pain, whereas several studies have highlighted the important contribution of the DRG in a non-injured nerve. Clarifying the role of neurotrophins in neuropathic pain is problematic because we cannot distinguish injured and intact neurons in most peripheral nerve injury models. In the present study, to elicit neuropathic pain, we used the spared nerve injury (SNI) model, in which injured DRG neurons are distinguishable from intact ones, and mechanical allodynia develops in the intact sural nerve skin territory. We examined nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) expression in the DRGs of SNI model mice. NGF and BDNF levels increased in the injured L3 DRG, while NGF decreased in the intact L5 DRG. These data offer a new point of view on the role of these neurotrophins in neuropathic pain induced by peripheral nerve injury. |
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| AbstractList | [Display omitted]
•Several studies have highlighted the important contribution of the DRG in a non-injured nerve.•We showed that a neurotrophin NGF was downregulated in intact DRG neurons after spared nerve injury.•Downregulation of NGF in intact DRG neurons may contribute to the neuropathic pain.
Neuropathic pain is initiated by a primary lesion in the peripheral nervous system and spoils quality of life. Neurotrophins play important roles in the development and transmission of neuropathic pain. There are conflicting reports that the dorsal root ganglion (DRG) in an injured nerve contribute to neuropathic pain, whereas several studies have highlighted the important contribution of the DRG in a non-injured nerve. Clarifying the role of neurotrophins in neuropathic pain is problematic because we cannot distinguish injured and intact neurons in most peripheral nerve injury models. In the present study, to elicit neuropathic pain, we used the spared nerve injury (SNI) model, in which injured DRG neurons are distinguishable from intact ones, and mechanical allodynia develops in the intact sural nerve skin territory. We examined nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) expression in the DRGs of SNI model mice. NGF and BDNF levels increased in the injured L3 DRG, while NGF decreased in the intact L5 DRG. These data offer a new point of view on the role of these neurotrophins in neuropathic pain induced by peripheral nerve injury. Neuropathic pain is initiated by a primary lesion in the peripheral nervous system and spoils quality of life. Neurotrophins play important roles in the development and transmission of neuropathic pain. There are conflicting reports that the dorsal root ganglion (DRG) in an injured nerve contribute to neuropathic pain, whereas several studies have highlighted the important contribution of the DRG in a non-injured nerve. Clarifying the role of neurotrophins in neuropathic pain is problematic because we cannot distinguish injured and intact neurons in most peripheral nerve injury models. In the present study, to elicit neuropathic pain, we used the spared nerve injury (SNI) model, in which injured DRG neurons are distinguishable from intact ones, and mechanical allodynia develops in the intact sural nerve skin territory. We examined nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) expression in the DRGs of SNI model mice. NGF and BDNF levels increased in the injured L3 DRG, while NGF decreased in the intact L5 DRG. These data offer a new point of view on the role of these neurotrophins in neuropathic pain induced by peripheral nerve injury. |
| Author | Terada, Yuki Shinjo, Takeaki Wanaka, Akio Tatsumi, Kouko Isonishi, Ayami Tanaka, Tatsuhide Morita-Takemura, Shoko Okuda, Hiroshi Kawaguchi, Masahiko |
| Author_xml | – sequence: 1 givenname: Yuki surname: Terada fullname: Terada, Yuki organization: Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan – sequence: 2 givenname: Shoko orcidid: 0000-0003-1872-4050 surname: Morita-Takemura fullname: Morita-Takemura, Shoko email: morita@naramed-u.ac.jp organization: Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan – sequence: 3 givenname: Ayami surname: Isonishi fullname: Isonishi, Ayami organization: Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan – sequence: 4 givenname: Tatsuhide surname: Tanaka fullname: Tanaka, Tatsuhide organization: Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan – sequence: 5 givenname: Hiroshi surname: Okuda fullname: Okuda, Hiroshi organization: Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan – sequence: 6 givenname: Kouko surname: Tatsumi fullname: Tatsumi, Kouko organization: Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan – sequence: 7 givenname: Takeaki surname: Shinjo fullname: Shinjo, Takeaki organization: Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan – sequence: 8 givenname: Masahiko surname: Kawaguchi fullname: Kawaguchi, Masahiko organization: Department of Anesthesiology, Nara Medical University, 840, Shijo-cho Kashihara, Nara 634-8522, Japan – sequence: 9 givenname: Akio orcidid: 0000-0001-9951-9862 surname: Wanaka fullname: Wanaka, Akio organization: Department of Anatomy & Neuroscience, Faculty of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan |
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| Cites_doi | 10.1046/j.0953-816x.2001.01591.x 10.1016/S0006-8993(97)01287-0 10.2337/diab.46.2.S43 10.1111/j.1085-9489.2004.09404.x 10.1097/00000542-200404000-00021 10.1016/0165-0270(94)90144-9 10.1016/j.neuroimage.2012.11.048 10.1523/JNEUROSCI.21-08-j0002.2001 10.1126/science.290.5489.124 10.1523/JNEUROSCI.21-13-04891.2001 10.1007/s00441-014-2080-9 10.1016/j.neuroscience.2010.03.017 10.1016/S0304-3959(00)00276-1 10.1016/S0006-8993(98)00335-7 10.1016/j.bbi.2014.08.003 10.1124/jpet.106.116236 10.1016/S0304-3940(03)00695-5 10.1016/j.pain.2008.01.016 10.1159/000052075 10.1006/exnr.1998.6936 10.1016/j.neuint.2016.03.007 10.1073/pnas.122231899 10.1186/1744-8069-10-19 10.1111/ner.12247 |
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| Keywords | Spared nerve injury BDNF DRG NGF Dorsal root ganglion SNI Neuropathic pain |
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•Several studies have highlighted the important contribution of the DRG in a non-injured nerve.•We showed that a neurotrophin NGF was... Neuropathic pain is initiated by a primary lesion in the peripheral nervous system and spoils quality of life. Neurotrophins play important roles in the... |
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| SubjectTerms | BDNF Dorsal root ganglion Neuropathic pain NGF Spared nerve injury |
| Title | NGF and BDNF expression in mouse DRG after spared nerve injury |
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