Rapid Identification of SARS-CoV-2 Omicron BA.5 Spike Mutation F486V in Clinical Specimens Using a High-Resolution Melting-Based Assay

• Published in: Viruses Vol. 14; no. 11; p. 2401
• Main Authors: Aoki, Akira, Adachi, Hirokazu, Mori, Yoko, Ito, Miyabi, Sato, Katsuhiko, Kinoshita, Masayoshi, Kuriki, Masahiro, Okuda, Kenji, Sakakibara, Toru, Okamoto, Yoshinori, Jinno, Hideto
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.10.2022; MDPI
• Subjects: BA.5; Biological Assay; Coronaviruses; COVID-19; COVID-19 - diagnosis; F486V mutation; Genomes; high-resolution melting; Humans; Methods; Microbiological assay; Mutation; Omicron subvariant; Public health; SARS-CoV-2 - genetics; Sensitivity and Specificity; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - genetics; Japan; South Africa; BA.5; F486V mutation; severe acute respiratory syndrome coronavirus 2; Omicron subvariant; high-resolution melting

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant BA.5 emerged as of February 2022 and replaced the earlier Omicron subvariants BA.1 and BA.2. COVID-19 genomic surveillance should be continued as new variants seem to subsequently appear, including post-BA.5 subvariants....