Exposure to PM2.5 Metal Constituents and Liver Cancer Risk in REVEAL-HBV
Background: Ambient particulate matter is classified as a human Class 1 carcinogen, and recent studies found a positive relationship between fine particulate matter (PM2.5) and liver cancer. Nevertheless, little is known about which specific metal constituent contributes to the development of liver...
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Published in | Journal of Epidemiology Vol. 34; no. 2; pp. 87 - 93 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Japan Epidemiological Association
05.02.2024
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Abstract | Background: Ambient particulate matter is classified as a human Class 1 carcinogen, and recent studies found a positive relationship between fine particulate matter (PM2.5) and liver cancer. Nevertheless, little is known about which specific metal constituent contributes to the development of liver cancer.Objective: To evaluate the association of long-term exposure to metal constituents in PM2.5 with the risk of liver cancer using a Taiwanese cohort study.Methods: A total of 13,511 Taiwanese participants were recruited from the REVEAL-HBV in 1991–1992. Participants’ long-term exposure to eight metal constituents (Ba, Cu, Mn, Sb, Zn, Pb, Ni, and Cd) in PM2.5 was based on ambient measurement in 2002–2006 followed by a land-use regression model for spatial interpolation. We ascertained newly developed liver cancer (ie, hepatocellular carcinoma [HCC]) through data linkage with the Taiwan Cancer Registry and national health death certification in 1991–2014. A Cox proportional hazards model was utilized to assess the association between exposure to PM2.5 metal component and HCC.Results: We identified 322 newly developed HCC with a median follow-up of 23.1 years. Long-term exposure to PM2.5 Cu was positively associated with a risk of liver cancer. The adjusted hazard ratio (HR) was 1.13 (95% confidence interval [CI], 1.02–1.25; P = 0.023) with one unit increment on Cu normalized by PM2.5 mass concentration in the logarithmic scale. The PM2.5 Cu-HCC association remained statistically significant with adjustment for co-exposures to other metal constituents in PM2.5.Conclusion: Our findings suggest PM2.5 containing Cu may attribute to the association of PM2.5 exposure with liver cancer. |
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AbstractList | Background: Ambient particulate matter is classified as a human Class 1 carcinogen, and recent studies found a positive relationship between fine particulate matter (PM2.5) and liver cancer. Nevertheless, little is known about which specific metal constituent contributes to the development of liver cancer. Objective: To evaluate the association of long-term exposure to metal constituents in PM2.5 with the risk of liver cancer using a Taiwanese cohort study. Methods: A total of 13,511 Taiwanese participants were recruited from the REVEAL-HBV in 1991–1992. Participants’ long-term exposure to eight metal constituents (Ba, Cu, Mn, Sb, Zn, Pb, Ni, and Cd) in PM2.5 was based on ambient measurement in 2002–2006 followed by a land-use regression model for spatial interpolation. We ascertained newly developed liver cancer (ie, hepatocellular carcinoma [HCC]) through data linkage with the Taiwan Cancer Registry and national health death certification in 1991–2014. A Cox proportional hazards model was utilized to assess the association between exposure to PM2.5 metal component and HCC. Results: We identified 322 newly developed HCC with a median follow-up of 23.1 years. Long-term exposure to PM2.5 Cu was positively associated with a risk of liver cancer. The adjusted hazard ratio (HR) was 1.13 (95% confidence interval [CI], 1.02–1.25; P = 0.023) with one unit increment on Cu normalized by PM2.5 mass concentration in the logarithmic scale. The PM2.5 Cu-HCC association remained statistically significant with adjustment for co-exposures to other metal constituents in PM2.5. Conclusion: Our findings suggest PM2.5 containing Cu may attribute to the association of PM2.5 exposure with liver cancer. |
ArticleNumber | JE20220262 |
Author | Chen, Yu-Cheng Wu, Chih-Da Lu, Tzu-Yi Chen, Chien-Jen Huang, Yen-Tsung Pan, Wen-Chi Yang, Hwai-I |
Author_xml | – sequence: 1 orcidid: 0000-0002-6651-2602 fullname: Lu, Tzu-Yi organization: Institute of Environmental and Occupational Health Sciences, National Yang Ming Chiao Tung University – sequence: 2 orcidid: 0000-0002-0588-8083 fullname: Wu, Chih-Da organization: Department of Geomatics, National Cheng Kung University – sequence: 3 orcidid: 0000-0002-0588-8083 fullname: Huang, Yen-Tsung organization: Institue of Statistical Science, Academia Sinica – sequence: 4 orcidid: 0000-0002-0588-8083 fullname: Chen, Yu-Cheng organization: National Institution of Environmental Health Sciences, National Health Research Institute – sequence: 5 orcidid: 0000-0002-0588-8083 fullname: Chen, Chien-Jen organization: Genomics Research Center, Academia Sinica – sequence: 6 orcidid: 0000-0002-0588-8083 fullname: Yang, Hwai-I organization: Genomics Research Center, Academia Sinica – sequence: 7 orcidid: 0000-0002-0588-8083 fullname: Pan, Wen-Chi organization: Institute of Environmental and Occupational Health Sciences, National Yang Ming Chiao Tung University |
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Cites_doi | 10.1016/j.cld.2007.08.005 10.18632/oncotarget.21463 10.1289/EHP172 10.1186/1476-069X-10-67 10.1056/NEJM200012143432401 10.1016/j.envres.2017.01.006 10.1056/NEJM199312093292401 10.1016/j.euf.2016.11.008 10.1002/ijc.33743 10.1016/j.ijheh.2016.08.001 10.1016/j.atmosenv.2007.05.022 10.1097/JOM.0000000000001676 10.1080/15287390903248869 10.1289/isee.2013.O-2-34-03 10.1136/oem.2007.034348 10.1021/es9006096 10.1016/j.jaerosci.2008.05.007 10.1002/ijc.32136 10.1289/ehp/1408092 10.1007/s10552-009-9412-1 10.1038/bjc.2017.1 10.5194/acp-10-9563-2010 10.1164/rccm.201106-1011OC 10.1016/j.envpol.2021.116652 10.1097/EDE.0000000000000076 10.1038/s41598-019-53959-9 10.1002/jat.3303 10.1016/S1470-2045(13)70487-X 10.1080/15287390701738491 10.1080/08958370802207326 10.4209/aaqr.2015.04.0261 10.1002/em.21797 10.3961/jpmph.15.014 10.1097/EDE.0b013e3182a77600 10.3390/ijerph16071213 10.3923/rjet.2017.55.61 10.1016/j.canep.2016.01.002 10.1016/j.atmosenv.2009.10.016 10.1053/j.gastro.2008.03.073 10.1016/j.cgh.2013.04.043 10.1016/j.scitotenv.2018.07.073 10.1093/jnci/djv341 10.1016/j.ecoenv.2019.110127 10.1007/s10552-018-1036-x 10.1016/j.cgh.2007.06.015 10.3319/TAO.2004.15.5.925(ADSE) 10.1016/j.envint.2015.11.007 |
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StartPage | 87 |
SubjectTerms | Environment fine particulate matter liver cancer metal constituents Original Taiwan |
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Title | Exposure to PM2.5 Metal Constituents and Liver Cancer Risk in REVEAL-HBV |
URI | https://www.jstage.jst.go.jp/article/jea/34/2/34_JE20220262/_article/-char/en https://pubmed.ncbi.nlm.nih.gov/PMC10751193 https://doaj.org/article/5a4f293689654d4b96a1f817aafead5c |
Volume | 34 |
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ispartofPNX | Journal of Epidemiology, 2024/02/05, Vol.34(2), pp.87-93 |
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