Association of maternal and fetal MTHFR A1298C polymorphism with the risk of pregnancy loss: a study of an Indian population and a meta-analysis

• Published in: Fertility and sterility Vol. 99; no. 5; pp. 1311 - 1318.e4
• Main Authors: Nair, Rohini R., Khanna, Anuradha, Singh, Rajender, Singh, Kiran
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2013
• Subjects: Abortion, Habitual - epidemiology; Abortion, Habitual - genetics; Abortion, Spontaneous - epidemiology; Abortion, Spontaneous - genetics; Adult; alleles; blood; Case-Control Studies; Female; Fetus - physiology; Genotype; genotyping; heterozygosity; homozygosity; Humans; hyperhomocysteinemia; Hyperhomocysteinemia - epidemiology; Hyperhomocysteinemia - genetics; India - epidemiology; Internal Medicine; meta-analysis; methylenetetrahydrofolate reductase; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; MTHFR A1298C SNP; Obstetrics and Gynecology; odds ratio; patients; polymerase chain reaction; Polymorphism, Single Nucleotide - genetics; Pregnancy; Prospective Studies; recurrent early pregnancy loss; regression analysis; restriction fragment length polymorphism; Risk Factors; sequence analysis; spontaneously aborted embryos; systematic review; women; India; hyperhomocysteinemia; recurrent early pregnancy loss; MTHFR A1298C SNP; spontaneously aborted embryos

To study the genetic association between methylenetetrahydrofolate reductase (MTHFR) A1298 polymorphism and recurrent pregnancy loss (RPL). Prospective case-control study, systematic review, and meta-analysis using an electronic database up to July 27, 2012. Meta-analysis of four studies on RPL and...