Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system

• Published in: Archives of virology Vol. 161; no. 6; pp. 1447 - 1454
• Main Authors: Suda, Yuto, Fukushi, Shuetsu, Tani, Hideki, Murakami, Shin, Saijo, Masayuki, Horimoto, Taisuke, Shimojima, Masayuki
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.06.2016; Springer Nature B.V
• Subjects: Animals; Arachnids; Biomedical and Life Sciences; Biomedicine; Cell Adhesion Molecules - physiology; Chlorocebus aethiops; Crimean-Congo hemorrhagic fever; Crimean-Congo hemorrhagic fever orthonairovirus; Crimean-Congo hemorrhagic fever virus; Dengue fever; Fatalities; Glycoproteins; HEK293 Cells; Hemorrhagic Fever Virus, Crimean-Congo - genetics; Hemorrhagic Fever Virus, Crimean-Congo - pathogenicity; Hemorrhagic Fever Virus, Crimean-Congo - physiology; Hemorrhagic Fever, Crimean - etiology; Hemorrhagic Fever, Crimean - virology; Humans; Infections; Infectious Diseases; Jurkat Cells; Lectins; Lectins, C-Type - physiology; Medical Microbiology; mortality; neutralization; Original; Original Article; Plasmids; Proteins; Receptors, Cell Surface - physiology; RNA polymerase; Vero Cells; Vesicular stomatitis Indiana virus - genetics; Vesicular stomatitis Indiana virus - physiology; Vesicular stomatitis virus; Vesiculovirus; Viral Envelope Proteins - genetics; Viral Envelope Proteins - physiology; Viral infections; Virology; Virus Internalization; Viruses; Japan; Severe Fever With Thrombocytopenia Syndrome Virus; Pseudotype Virus; Rift Valley Fever Virus; Jurkat Cell; Vesicular Stomatitis Indiana Virus

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease causing severe hemorrhagic symptoms with a nearly 30 % case-fatality rate in humans. The experimental use of CCHF virus (CCHFV), which causes CCHF, requires high-biosafety-level (BSL) containment. In contrast, pseudotyping of various vir...