Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus

• Published in: Arthritis research & therapy Vol. 19; no. 1; p. 138
• Main Authors: Aterido, Adrià, Julià, Antonio, Carreira, Patricia, Blanco, Ricardo, López-Longo, José Javier, Venegas, José Javier Pérez, Olivé, Àlex, Andreu, José Luís, Aguirre-Zamorano, Maria Ángeles, Vela, Paloma, Nolla, Joan M, Marenco-de la Fuente, José Luís, Zea, Antonio, Pego, José María, Freire, Mercedes, Díez, Elvira, López-Lasanta, María, López-Corbeto, Mireia, Palau, Núria, Tortosa, Raül, Gelpí, Josep Lluís, Absher, Devin, Myers, Richard M, Fernández-Nebro, Antonio, Marsal, Sara
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.06.2017; BioMed Central; BMC
• Subjects: Adult; Analysis; Arthritis; Autoimmune diseases; Clinical phenotypes; Consortia; Development and progression; Disease; Factor de creixement de l'endoteli vascular; Female; Fenotip; Genealogy; Genes; Genetic aspects; Genetic Predisposition to Disease - genetics; Genetic Variation; Genetics; Genoma humà; Genome-wide association studies; Genome-Wide Association Study; Genome-wide pathway analysis; Genomes; Genotype; Human genome; Humans; Identification; Lupus; Lupus eritematós; Lupus erythematosus; Lupus Erythematosus, Systemic - complications; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - pathology; Malalties autoimmunitàries; Male; Oral Ulcer - genetics; Oral ulceration; Phenotype; Physiological aspects; Psoriasis; Rheumatology; Systemic lupus erythematosus; Ulcers; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - genetics; Vascular endothelial growth factors; Úlceres; Oral ulceration; Genetics; Systemic lupus erythematosus; Clinical phenotypes; Genome-wide pathway analysis

Systemic lupus erythematosus (SLE) is a genetically complex rheumatic disease characterized by heterogeneous clinical manifestations of unknown etiology. Recent studies have suggested the existence of a genetic basis for SLE heterogeneity. The objective of the present study was to identify new genet...