Anticancer metallohelices: nanomolar potency and high selectivity

• Published in: Chemical science (Cambridge) Vol. 7; no. 2; pp. 951 - 958
• Main Authors: Kaner, Rebecca A, Allison, Simon J, Faulkner, Alan D, Phillips, Roger M, Roper, David I, Shepherd, Samantha L, Simpson, Daniel H, Waterfield, Nicholas R, Scott, Peter
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 01.01.2016
• Subjects: Acanthamoeba polyphaga; Biotechnology; Cancer; Chemistry; Escherichia coli; Larvae; Manduca sexta; Nanostructure; Selectivity; Self assembly; Staphylococcus aureus; Toxicity

A range of new helicate-like architectures have been prepared via highly diastereoselective self-assembly using readily accessible starting materials. Six pairs of enantiomers [Fe 2 L 3 ]Cl 4 · n H 2 O (L = various bidentate ditopic ligands NN-NN) show very good water solubility and stability. Their...