Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

• Published in: Nature genetics Vol. 48; no. 8; pp. 940 - 946
• Main Authors: Morris, David L, Sheng, Yujun, Zhang, Yan, Wang, Yong-Fei, Zhu, Zhengwei, Tombleson, Philip, Chen, Lingyan, Cunninghame Graham, Deborah S, Bentham, James, Roberts, Amy L, Chen, Ruoyan, Zuo, Xianbo, Wang, Tingyou, Wen, Leilei, Yang, Chao, Liu, Lu, Yang, Lulu, Li, Feng, Huang, Yuanbo, Yin, Xianyong, Yang, Sen, Rönnblom, Lars, Fürnrohr, Barbara G, Voll, Reinhard E, Schett, Georg, Costedoat–Chalumeau, Nathalie, Gaffney, Patrick M, Lau, Yu Lung, Zhang, Xuejun, Yang, Wanling, Cui, Yong, Vyse, Timothy J
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.08.2016; Nature Publishing Group
• Subjects: 38/39; 45/43; 631/208/205/2138; 692/699/249/1313/1613; Agriculture; Animal Genetics and Genomics; Asian People - genetics; Autoimmune diseases; Biomedicine; Cancer Research; Case-Control Studies; Gene expression; Gene Function; Genetic aspects; Genetic Loci - genetics; Genetic Predisposition to Disease; Genome-wide association studies; Genome-Wide Association Study; Genomes; Health risk assessment; Human Genetics; Humans; Identification and classification; letter; Lupus Erythematosus, Systemic - genetics; Lymphocytes; Medical Science; Medicinsk vetenskap; Meta-analysis; Methods; Polymorphism, Single Nucleotide - genetics; Population; Quality control; Quantitative trait loci; Risk factors; Statistical analysis; Studies; Systemic lupus erythematosus; White People - genetics; Hong Kong China; China

Timothy Vyse, Yong Cui, Wanling Yang and colleagues report a meta-analysis of genome-wide association studies for systemic lupus erythematosus (SLE) including European and Chinese individuals. They identify ten new loci associated with SLE and find evidence for increased genetic risk of disease amon...