Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

Timothy Vyse, Yong Cui, Wanling Yang and colleagues report a meta-analysis of genome-wide association studies for systemic lupus erythematosus (SLE) including European and Chinese individuals. They identify ten new loci associated with SLE and find evidence for increased genetic risk of disease amon...

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Published inNature genetics Vol. 48; no. 8; pp. 940 - 946
Main Authors Morris, David L, Sheng, Yujun, Zhang, Yan, Wang, Yong-Fei, Zhu, Zhengwei, Tombleson, Philip, Chen, Lingyan, Cunninghame Graham, Deborah S, Bentham, James, Roberts, Amy L, Chen, Ruoyan, Zuo, Xianbo, Wang, Tingyou, Wen, Leilei, Yang, Chao, Liu, Lu, Yang, Lulu, Li, Feng, Huang, Yuanbo, Yin, Xianyong, Yang, Sen, Rönnblom, Lars, Fürnrohr, Barbara G, Voll, Reinhard E, Schett, Georg, Costedoat–Chalumeau, Nathalie, Gaffney, Patrick M, Lau, Yu Lung, Zhang, Xuejun, Yang, Wanling, Cui, Yong, Vyse, Timothy J
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.08.2016
Nature Publishing Group
Subjects
38/39
45/43
631/208/205/2138
692/699/249/1313/1613
Agriculture
Animal Genetics and Genomics
Asian People - genetics
Autoimmune diseases
Biomedicine
Cancer Research
Case-Control Studies
Gene expression
Gene Function
Genetic aspects
Genetic Loci - genetics
Genetic Predisposition to Disease
Genome-wide association studies
Genome-Wide Association Study
Genomes
Health risk assessment
Human Genetics
Humans
Identification and classification
letter
Lupus Erythematosus, Systemic - genetics
Lymphocytes
Medical Science
Medicinsk vetenskap
Meta-analysis
Methods
Polymorphism, Single Nucleotide - genetics
Population
Quality control
Quantitative trait loci
Risk factors
Statistical analysis
Studies
Systemic lupus erythematosus
White People - genetics
Hong Kong China
China
Online AccessGet full text

Cover

Abstract Timothy Vyse, Yong Cui, Wanling Yang and colleagues report a meta-analysis of genome-wide association studies for systemic lupus erythematosus (SLE) including European and Chinese individuals. They identify ten new loci associated with SLE and find evidence for increased genetic risk of disease among individuals of non-European ancestry. Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune disease. Genome-wide association studies (GWASs) have identified more than 50 loci as robustly associated with the disease in single ancestries, but genome-wide transancestral studies have not been conducted. We combined three GWAS data sets from Chinese (1,659 cases and 3,398 controls) and European (4,036 cases and 6,959 controls) populations. A meta-analysis of these studies showed that over half of the published SLE genetic associations are present in both populations. A replication study in Chinese (3,043 cases and 5,074 controls) and European (2,643 cases and 9,032 controls) subjects found ten previously unreported SLE loci. Our study provides further evidence that the majority of genetic risk polymorphisms for SLE are contained within the same regions across both populations. Furthermore, a comparison of risk allele frequencies and genetic risk scores suggested that the increased prevalence of SLE in non-Europeans (including Asians) has a genetic basis.
AbstractList Timothy Vyse, Yong Cui, Wanling Yang and colleagues report a meta-analysis of genome-wide association studies for systemic lupus erythematosus (SLE) including European and Chinese individuals. They identify ten new loci associated with SLE and find evidence for increased genetic risk of disease among individuals of non-European ancestry. Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune disease. Genome-wide association studies (GWASs) have identified more than 50 loci as robustly associated with the disease in single ancestries, but genome-wide transancestral studies have not been conducted. We combined three GWAS data sets from Chinese (1,659 cases and 3,398 controls) and European (4,036 cases and 6,959 controls) populations. A meta-analysis of these studies showed that over half of the published SLE genetic associations are present in both populations. A replication study in Chinese (3,043 cases and 5,074 controls) and European (2,643 cases and 9,032 controls) subjects found ten previously unreported SLE loci. Our study provides further evidence that the majority of genetic risk polymorphisms for SLE are contained within the same regions across both populations. Furthermore, a comparison of risk allele frequencies and genetic risk scores suggested that the increased prevalence of SLE in non-Europeans (including Asians) has a genetic basis.
Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune disease. Genome-wide association studies (GWASs) have identified more than 50 loci as robustly associated with the disease in single ancestries, but genome-wide transancestral studies have not been conducted. We combined three GWAS data sets from Chinese (1,659 cases and 3,398 controls) and European (4,036 cases and 6,959 controls) populations. A meta-analysis of these studies showed that over half of the published SLE genetic associations are present in both populations. A replication study in Chinese (3,043 cases and 5,074 controls) and European (2,643 cases and 9,032 controls) subjects found ten previously unreported SLE loci. Our study provides further evidence that the majority of genetic risk polymorphisms for SLE are contained within the same regions across both populations. Furthermore, a comparison of risk allele frequencies and genetic risk scores suggested that the increased prevalence of SLE in non-Europeans (including Asians) has a genetic basis.
Systemic lupus erythematosus (SLE; OMIM 1 152700) is a genetically complex autoimmune disease. Genome-wide association studies (GWASs) have identified more than 50 loci as robustly associated with the disease in single ancestries, but genome-wide transancestral studies have not been conducted. We combined three GWAS data sets from Chinese (1,659 cases and 3,398 controls) and European (4,036 cases and 6,959 controls) populations. A meta-analysis of these studies showed that over half of the published SLE genetic associations are present in both populations. A replication study in Chinese (3,043 cases and 5,074 controls) and European (2,643 cases and 9,032 controls) subjects found ten previously unreported SLE loci. Our study provides further evidence that the majority of genetic risk polymorphisms for SLE are contained within the same regions across both populations. Furthermore, a comparison of risk allele frequencies and genetic risk scores suggested that the increased prevalence of SLE in non-Europeans (including Asians) has a genetic basis.
Audience Academic
Author Yin, Xianyong
Fürnrohr, Barbara G
Chen, Lingyan
Vyse, Timothy J
Schett, Georg
Chen, Ruoyan
Tombleson, Philip
Zuo, Xianbo
Yang, Sen
Morris, David L
Wen, Leilei
Yang, Lulu
Yang, Chao
Zhang, Yan
Cunninghame Graham, Deborah S
Zhang, Xuejun
Roberts, Amy L
Wang, Tingyou
Zhu, Zhengwei
Liu, Lu
Yang, Wanling
Bentham, James
Gaffney, Patrick M
Lau, Yu Lung
Li, Feng
Sheng, Yujun
Costedoat–Chalumeau, Nathalie
Huang, Yuanbo
Rönnblom, Lars
Voll, Reinhard E
Cui, Yong
Wang, Yong-Fei
AuthorAffiliation 6 Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
7 Department of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
14 Centre for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany
5 Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
1 Division of Genetics and Molecular Medicine, King’s College London, London, UK
11 Division of Biological Chemistry, Medical University Innsbruck, Innsbruck, Austria
10 Division of Genetic Epidemiology, Medical University Innsbruck, Innsbruck, Austria
13 Department of Rheumatology and Clinical Immunology, University Hospital Freiburg, Freiburg, Germany
2 Department of Dermatology, No. 1 Hospital, Anhui Medical University, Hefei, Anhui, China
15 AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Paris, France
18 The University of Hong Kong Shenz
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– name: 16 Université Paris Descartes–Sorbonne Paris Cité, Paris, France
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  organization: Division of Genetics and Molecular Medicine, King's College London, Division of Immunology, Infection and Inflammatory Disease, King's College London
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27399966$$D View this record in MEDLINE/PubMed
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300367$$DView record from Swedish Publication Index
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    fullname: G Hom
– volume: 50
  start-page: 812
  year: 2013
  ident: BFng3603_CR8
  publication-title: J. Med. Genet.
  doi: 10.1136/jmedgenet-2013-101787
  contributor:
    fullname: Y Li
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Snippet Timothy Vyse, Yong Cui, Wanling Yang and colleagues report a meta-analysis of genome-wide association studies for systemic lupus erythematosus (SLE) including...
Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune disease. Genome-wide association studies (GWASs) have identified more than...
Systemic lupus erythematosus (SLE; OMIM 1 152700) is a genetically complex autoimmune disease. Genome-wide association studies (GWASs) have identified more...
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StartPage 940
SubjectTerms 38/39
45/43
631/208/205/2138
692/699/249/1313/1613
Agriculture
Animal Genetics and Genomics
Asian People - genetics
Autoimmune diseases
Biomedicine
Cancer Research
Case-Control Studies
Gene expression
Gene Function
Genetic aspects
Genetic Loci - genetics
Genetic Predisposition to Disease
Genome-wide association studies
Genome-Wide Association Study
Genomes
Health risk assessment
Human Genetics
Humans
Identification and classification
letter
Lupus Erythematosus, Systemic - genetics
Lymphocytes
Medical Science
Medicinsk vetenskap
Meta-analysis
Methods
Polymorphism, Single Nucleotide - genetics
Population
Quality control
Quantitative trait loci
Risk factors
Statistical analysis
Studies
Systemic lupus erythematosus
White People - genetics
Title Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus
URI https://link.springer.com/article/10.1038/ng.3603
https://www.ncbi.nlm.nih.gov/pubmed/27399966
https://www.proquest.com/docview/1807869866
https://search.proquest.com/docview/1807899634
https://pubmed.ncbi.nlm.nih.gov/PMC4966635
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-300367
Volume 48
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