Gene expression elucidates functional impact of polygenic risk for schizophrenia

• Published in: Nature neuroscience Vol. 19; no. 11; pp. 1442 - 1453
• Main Authors: Fromer, Menachem, Roussos, Panos, Sieberts, Solveig K, Johnson, Jessica S, Kavanagh, David H, Perumal, Thanneer M, Ruderfer, Douglas M, Oh, Edwin C, Topol, Aaron, Shah, Hardik R, Klei, Lambertus L, Kramer, Robin, Pinto, Dalila, Gümüş, Zeynep H, Cicek, A Ercument, Dang, Kristen K, Browne, Andrew, Lu, Cong, Xie, Lu, Readhead, Ben, Stahl, Eli A, Xiao, Jianqiu, Parvizi, Mahsa, Hamamsy, Tymor, Fullard, John F, Wang, Ying-Chih, Mahajan, Milind C, Derry, Jonathan M J, Dudley, Joel T, Hemby, Scott E, Logsdon, Benjamin A, Talbot, Konrad, Raj, Towfique, Bennett, David A, De Jager, Philip L, Zhu, Jun, Zhang, Bin, Sullivan, Patrick F, Chess, Andrew, Purcell, Shaun M, Shinobu, Leslie A, Mangravite, Lara M, Toyoshiba, Hiroyoshi, Gur, Raquel E, Hahn, Chang-Gyu, Lewis, David A, Haroutunian, Vahram, Peters, Mette A, Lipska, Barbara K, Buxbaum, Joseph D, Schadt, Eric E, Hirai, Keisuke, Roeder, Kathryn, Brennand, Kristen J, Katsanis, Nicholas, Domenici, Enrico, Devlin, Bernie, Sklar, Pamela
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.11.2016; Nature Publishing Group
• Subjects: 13/100; 38/22; 38/39; 45/100; 45/43; 45/91; 631/208/199; 631/208/212; 631/378/2583; 64/116; 692/699/476/1799; 706/648/697/129; Alzheimer's disease; Animal Genetics and Genomics; Behavioral Sciences; Biological Techniques; Biology; Biomedicine; Brain - metabolism; Brain research; Consortia; Danio rerio; Disease; Female; Gene expression; Gene Expression Regulation - genetics; Gene loci; Genetic aspects; Genetic Predisposition to Disease; Genetics; Genome-Wide Association Study; Genomics; Health risk assessment; Humans; Male; Medicine; Mental disorders; Multifactorial Inheritance - genetics; Neurobiology; Neurosciences; Pharmaceutical industry; Physiological aspects; Polymorphism, Single Nucleotide; Psychiatry; Risk; Risk factors; Schizophrenia; Schizophrenia - genetics; United States; Japan; North Carolina; New York; United States > US; Massachusetts; Pittsburgh Pennsylvania; Pennsylvania

The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of subjects with schizophrenia ( N = 258) and control subjects ( N = 279), creating a resource of gene expression and its genetic regulation. Using this resource, they found that ∼20% of schizophrenia loci have variants that...