Inhibition of Autophagy by Estradiol Promotes Locomotor Recovery after Spinal Cord Injury in Rats

• Published in: Neuroscience bulletin Vol. 32; no. 2; pp. 137 - 144
• Main Authors: Lin, Chao-Wei, Chen, Bi, Huang, Ke-Lun, Dai, Yu-Sen, Teng, Hong-Lin
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.04.2016; Springer
• Subjects: 17β-雌二醇; Anatomy; Anesthesiology; Animals; Autophagy - drug effects; Beclin-1 - genetics; Beclin-1 - metabolism; Biomedical and Life Sciences; Biomedicine; blot分析; Disease Models, Animal; Down-Regulation - drug effects; Estradiol; Estradiol - blood; Estradiol - pharmacology; Estradiol - therapeutic use; Estrogens - blood; Estrogens - pharmacology; Estrogens - therapeutic use; Female; Follow-Up Studies; Human Physiology; Hydrogen Peroxide - metabolism; Locomotion - drug effects; Microtubule-Associated Proteins - genetics; Microtubule-Associated Proteins - metabolism; Motor Neurons - drug effects; Nervous system diseases; Neurology; Neurosciences; Original; Original Article; Ovariectomy; Pain Medicine; PC12 Cells; Phenols; Rats; Rats, Sprague-Dawley; Recovery of Function - drug effects; Spinal cord injuries; Spinal Cord Injuries - drug therapy; Spinal Cord Injuries - pathology; 中枢神经系统疾病; 大鼠; 实时定量PCR; 神经保护作用; 脊髓损伤; 运动神经元; 17β-estradiol; Motor neuron; Spinal cord injury; Autophagy

17β-estradiol（E2） has been shown to have neuroprotective effects in different central nervous system diseases. The mechanisms underlying estrogen neuroprotection in spinal cord injury（SCI） remain unclear. Previous studies have shown that autophagy plays a crucial role in the course of nerve injury....