Discovery of PACAP and its receptors in the brain

• Published in: Journal of headache and pain Vol. 19; no. 1; pp. 28 - 8
• Main Authors: Hirabayashi, Takahiro, Nakamachi, Tomoya, Shioda, Seiji
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 04.04.2018; Springer Nature B.V; BMC
• Subjects: Animals; G protein-coupled receptors; Glucagon; Homology; Humans; Internal Medicine; Intestine; Medicine; Medicine & Public Health; Neurology; Neuropeptide; PAC1 protein; PAC1-R; PACAP; Pain Medicine; Pituitary; Pituitary adenylate cyclase-activating polypeptide; Pituitary Adenylate Cyclase-Activating Polypeptide - physiology; Polypeptides; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - physiology; Review; Review Article; Secretin; Vasoactive agents; Vasoactive intestinal peptide; VPAC1-R; VPAC2-R; PAC1-R; G protein-coupled receptors; PACAP; VPAC1-R; VPAC2-R; Molecular cloning; Neuropeptide

Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon/secretin family. PACAP shows particularly high homology (~ 68%) to VIP. Because of the high homology of the amino acid sequences of...