Heparin attenuates symptoms and mast cell degranulation induced by AMP nasal provocation

• Published in: Journal of allergy and clinical immunology Vol. 114; no. 2; pp. 316 - 320
• Main Authors: Zeng, Dewan, Prosperini, Gaetano, Russo, Cristina, Spicuzza, Lucia, Cacciola, Rosella R, Di Maria, Guiseppe U, Polosa, Riccardo
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Mosby, Inc 01.08.2004; Elsevier; Elsevier Limited
• Subjects: adenosine challenge; Adenosine Monophosphate - pharmacology; Adolescent; Adult; allergic rhinitis; Allergies; Biological and medical sciences; Cell Degranulation - drug effects; Drug therapy; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Heparin; Heparin - pharmacology; Histamine; Histamine - analysis; Humans; Immunopathology; Male; Mast Cells - drug effects; Mast Cells - physiology; Medical sciences; Nasal Mucosa - chemistry; Nose; Rhinitis, Allergic, Perennial - drug therapy; Rhinitis, Allergic, Seasonal - drug therapy; Serine Endopeptidases - analysis; Sneezing; Studies; tryptase; Tryptases; NLF; histamine; Heparin; allergic rhinitis; adenosine challenge; tryptase; Allergy; Immunopathology; EC 3.4.21.59; Nose disease; Purine nucleoside; Adenosine; Serine endopeptidases; AMP; Rhinitis; Enzyme; Anticoagulant; Peptidases; Histamine; Symptomatology; Immunology; Tryptase; Degranulation; Glycosaminoglycan; Hydrolases; ENT disease; Mast cell

Previous studies have shown that inhaled heparin attenuated the airway responses to allergen, exercise, and AMP bronchial provocation, possibly through an inhibition of mast cell activation. The aim of this study was to provide the evidence of in vivo inhibition of human mast cell activation by hepa...