Functional Analysis and DNA Polymorphism of the Tandemly Repeated Sequences in the 5'-terminal Regulatory Region of the Human Gene for Thymidylate Synthase

• Published in: Cell Structure and Function Vol. 20; no. 3; pp. 191 - 197
• Main Authors: Horie, Nobuyuki, Aiba, Hideo, Oguro, Katsuhiko, Hojo, Hiroatsu, Takeishi, Keiichi
• Format: Journal Article
• Language: English
• Published: Japan Japan Society for Cell Biology 1995; Japan Science and Technology Agency
• Subjects: Base Sequence; DNA - analysis; DNA polymorphism; gene expression; gene regulation; HeLa Cells; human gene; Humans; Molecular Sequence Data; Polymorphism, Genetic; Repetitive Sequences, Nucleic Acid; thymidylate synthase; Thymidylate Synthase - genetics

Triple tandemly repeated sequences and the corresponding complementary sequence are known to exist in the 5'-terminal regulatory region of the human gene for thymidylate synthase (TS). To examine the function of these sequences, a set of deletion mutants was prepared and used in a transient exp...