Nerve growth factor: an update on the science and therapy
Summary Objective Nerve growth factor (NGF) is a key regulator of nociceptive pain and thus appears to be an interesting target molecule for an innovative class of analgesic medication. We set out to review the principles of neurogenic inflammation and results of anti-NGF regimens in animal studies...
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Published in | Osteoarthritis and cartilage Vol. 21; no. 9; pp. 1223 - 1228 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
01.09.2013
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Abstract | Summary Objective Nerve growth factor (NGF) is a key regulator of nociceptive pain and thus appears to be an interesting target molecule for an innovative class of analgesic medication. We set out to review the principles of neurogenic inflammation and results of anti-NGF regimens in animal studies as well as clinical trials with patients with back pain and osteoarthritis (OA). Design We searched using Google Scholar Search and Pubmed as well as through conference reports for articles and abstracts related to NGF and clinical trials using anti-NGF regimens. We report on efficacy findings and adverse events (AEs) related to these agents in this review. Results We identified five full articles and eight abstract reports relating to anti-NGF agents studied for use in back pain and in OA. Conclusions Anti-NGF agents either alone or in combination with non-steroidal anti-inflammatory agents (NSAIDs) were more efficacious for the treatment of pain in a number of trials of knee and hip pain compared to NSAIDs alone. However, adverse effects that included rapidly progressive OA and joint replacement were more common in patients treated with anti-NGF and NSAIDs than either treatment alone. Anti-NGF treatment related neurologic symptoms including paresthesias, and potentially other types of adverse effects were usually transient but warrant additional investigation. |
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AbstractList | Summary Objective Nerve growth factor (NGF) is a key regulator of nociceptive pain and thus appears to be an interesting target molecule for an innovative class of analgesic medication. We set out to review the principles of neurogenic inflammation and results of anti-NGF regimens in animal studies as well as clinical trials with patients with back pain and osteoarthritis (OA). Design We searched using Google Scholar Search and Pubmed as well as through conference reports for articles and abstracts related to NGF and clinical trials using anti-NGF regimens. We report on efficacy findings and adverse events (AEs) related to these agents in this review. Results We identified five full articles and eight abstract reports relating to anti-NGF agents studied for use in back pain and in OA. Conclusions Anti-NGF agents either alone or in combination with non-steroidal anti-inflammatory agents (NSAIDs) were more efficacious for the treatment of pain in a number of trials of knee and hip pain compared to NSAIDs alone. However, adverse effects that included rapidly progressive OA and joint replacement were more common in patients treated with anti-NGF and NSAIDs than either treatment alone. Anti-NGF treatment related neurologic symptoms including paresthesias, and potentially other types of adverse effects were usually transient but warrant additional investigation. Nerve growth factor (NGF) is a key regulator of nociceptive pain and thus appears to be an interesting target molecule for an innovative class of analgesic medication. We set out to review the principles of neurogenic inflammation and results of anti-NGF regimens in animal studies as well as clinical trials with patients with back pain and osteoarthritis (OA). We searched using Google Scholar Search and Pubmed as well as through conference reports for articles and abstracts related to NGF and clinical trials using anti-NGF regimens. We report on efficacy findings and adverse events (AEs) related to these agents in this review. We identified five full articles and eight abstract reports relating to anti-NGF agents studied for use in back pain and in OA. Anti-NGF agents either alone or in combination with non-steroidal anti-inflammatory agents (NSAIDs) were more efficacious for the treatment of pain in a number of trials of knee and hip pain compared to NSAIDs alone. However, adverse effects that included rapidly progressive OA and joint replacement were more common in patients treated with anti-NGF and NSAIDs than either treatment alone. Anti-NGF treatment related neurologic symptoms including paresthesias, and potentially other types of adverse effects were usually transient but warrant additional investigation. |
Author | Lane, N.E Wise, B.L Seidel, M.F |
AuthorAffiliation | Medizinische Klinik und Poliklinik III, University Hospital, Section of Rheumatology, Sigmund-Freud-Straße 25, D-53127 Bonn, Germany University of California, Davis School of Medicine, Center for Musculoskeletal Health, 4625 2nd Avenue, Suite 1002, Sacramento, CA 95817, USA |
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Keywords | Receptor antagonists Nerve growth factor Neurogenic inflammation Osteoarthitis |
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Snippet | Summary Objective Nerve growth factor (NGF) is a key regulator of nociceptive pain and thus appears to be an interesting target molecule for an innovative... Nerve growth factor (NGF) is a key regulator of nociceptive pain and thus appears to be an interesting target molecule for an innovative class of analgesic... |
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SubjectTerms | Analgesics - administration & dosage Analgesics - adverse effects Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - adverse effects Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Back Pain - drug therapy Humans Nerve growth factor Nerve Growth Factor - antagonists & inhibitors Neuritis - drug therapy Neurogenic inflammation Osteoarthitis Osteoarthritis - drug therapy Receptor antagonists Rheumatology |
Title | Nerve growth factor: an update on the science and therapy |
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